Visualization of orbital retinoblastoma with technetium-99m (V) dimercaptosuccinic acid

Kıratlı, Pınar Özgen; Kıratlı, Hayyam; Ercan, Meral T.

doi:10.1007/bf03164782

Cited by 11 publications

(4 citation statements)

References 11 publications

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“…Systemic evaluation and metastatic work up, including a detailed physical examination, which includes orbital examination and regional lymph node examination, complete haemogram, chest X-ray, ultrasonography of the abdomen, bone marrow biopsy, and cerebrospinal fluid cytology, are necessary to stage the disease. Whole body bone scans using Technetium-99 and Flourine-18 flourodeoxyglucose positron emission tomography (PET CT) scans are also useful for early detection of subclinical systemic metastasis [24,25]. If regional lymph nodes are enlarged, a fine needle aspiration biopsy should be done to look for malignant cells.…”

Section: Management Of Orbital Retinoblastoma In Indiamentioning

confidence: 99%

Retinoblastoma in Asia

Jain

Rojanaporn

Chawla

et al. 2018

Eye

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Asia-Pacific region bears a significant global burden of retinoblastoma (RB), therefore understanding RB in Asia-Pacific region is important. Based on the year 2013 population estimates, 43% (3452 of 8099 children) of the global burden of RB lives in 6 countries of Asia-Pacific region: 1486 children in India, 1103 children in China, 277 children in Indonesia, 260 children in Pakistan, 184 children in Bangladesh, 142 children in Philippines. There exists a wide disparity, technological and socio-economical, within countries in this region resulting in a varied pattern of clinical presentation and survival varies.Challenges in developing nations are not just technological, but also social. Opportunities emerge for research to study and understand the socio-economical aspects of the disease to develop interventions that are relevant culturally and feasible economically. Possible steps include disease education and counselling, universal screening, highly subsidized/free of cost treatment for low socioeconomic strata, raising funds through the government and non-governmental organizations, sensitization and training of man-power in screening, diagnosis and treatment, and developing new specialized centers with tele-ophthalmology services.

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Section: Management Of Orbital Retinoblastoma In Indiamentioning

confidence: 99%

Retinoblastoma in Asia

Jain

Rojanaporn

Chawla

et al. 2018

Eye

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“…Technetium-99 bone scan and positron emission tomography coupled with computed tomography may be useful modalities for the early detection of subclinical systemic metastasis. [2324] Orbital biopsy is rarely required and should be considered specifically when a child presents with an orbital mass following enucleation or evisceration where the primary histopathology is unavailable.…”

Section: Diagnostic Evaluationmentioning

confidence: 99%

Orbital retinoblastoma: An update

Honavar

Manjandavida

Reddy

2017

Indian J Ophthalmol

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Orbital extension is a major cause of death in children with retinoblastoma in the developing countries. Delayed detection and inappropriate management contribute to poor outcome. Conventional treatment including primary orbital exenteration or chemotherapy or radiotherapy alone result in mortality as high as 70%. The recent understanding on the role of sequential multimodal therapy with a combination of high-dose chemotherapy, followed by appropriate surgery, radiotherapy, and additional adjuvant chemotherapy has helped dramatically improve life salvage.

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“…[46,47] MRI is also being increasing used to study the biocolonization of the orbital implant. [48] Whole body bone scans using technetium-99, as shown by Kiratli et al, [49] and flourine-18 flourodeoxyglucose positron emission tomography (PET CT), as demonstrated by Moll et al, [50] reflect a glimpse of what possibly lies in store for early detection of metastasis.…”

Section: New Frontiers Of the Futurementioning

confidence: 98%

Orbital retinoblastoma: Where do we go from here?

et al. 2011

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Diagnosis of orbital retinoblastoma traditionally carries a dismal prognosis. Although its incidence is less in the developed countries, it continues to contribute to an epidemic of extraocular disease at diagnosis in the developing world. Orbital retinoblastoma encompasses a wide range of distinct clinical entities with varying tumor load. There are no standard treatment protocols as of now but the current preferred management is multimodal with a combination of initial high-dose chemotherapy, surgery, external beam radiotherapy and prolonged chemotherapy for 12 cycles. Though orbital retinoblastoma is a catastrophic event, rapid advances on many fronts, especially the genetic, makes the future appear brighter than what it is now. This review looks at all the new frontiers that are in store in the near as well as the distant future. Looking at the ever expanding horizons makes one believe of a definite hope that one day we will conquer this disease as we have conquered many others in the past.

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Visualization of orbital retinoblastoma with technetium-99m (V) dimercaptosuccinic acid

Cited by 11 publications

References 11 publications

Retinoblastoma in Asia

Retinoblastoma in Asia

Orbital retinoblastoma: An update

Orbital retinoblastoma: Where do we go from here?

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