Visualization of size-dependent tumour retention of PEGylated nanographene oxide via SPECT imaging

Cao, Tianye; You, Pei-Hong; Zhou, Xiaobao; Luo, Jianmin; Xu, Xiaoping; Zhou, Zhiguo; Yang, Shiping; Zhang, Yingjian; Yang, Hong; Wang, Mingwei

doi:10.1039/c6tb01892k

Cited by 21 publications

(19 citation statements)

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“…50-60%, with high in vitro serum and in vivo stability. 163,164,552 Radioiodination was suggested to occur at the edges of the graphene sheets where defects exist. The nonchelator labelling of different types of graphene-based NPs with various radiometals has also been reported (Table 14).…”

Section: Radiolabelling Of Organic Nanomaterialsmentioning

confidence: 99%

Radiolabelling of nanomaterials for medical imaging and therapy

2021

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Section: Radiolabelling Of Organic Nanomaterialsmentioning

confidence: 99%

Radiolabelling of nanomaterials for medical imaging and therapy

2021

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“…Graphene‐based nanomaterials as upcoming nanoplatforms are assuming an imperative part in PET/SPECT imaging. A strategy has been built to label nGO–PEG with 125 I by securing iodine molecules on the deformities and edges of GO . In light of this strategy, various studies have been conducted.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Graphene and Graphene‐Based Materials in Biomedical Science

Swetha

Manisha

Prasad

2018

Part & Part Syst Charact

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Graphene and its composite materials are very important in many disciplines of science and have been used enormously by researchers since their discovery in 2004. These are a new group of compounds, and are also wonderful model systems for quantum behavior studies. Their properties like exceptional conductivity, biocompatibility, surface area, mechanical strength, and thermal properties make them rising stars in the scientific community. Graphene and its composite compounds are utilized widely in different medical applications, for example, biosensing of biological compounds responsible for disease development, bioimaging of various cells, tissues, microorganisms, animal models, etc. In addition, they are used for enhancing and supporting the stem cell differentiation, i.e., regenerative medicine for regeneration studies of various human organs, tissue engineering in biology for the development of carrier materials, as well as in bone reformation. This review focuses on the modification procedure involved in the fabrication of graphene‐based biomaterials for various applications and recent developments in research related to graphene and graphene‐based materials in biosensing, optical sensing, gas sensing, drug, gene, protein delivery, tissue engineering, and bioimaging. In addition, the potential toxicological effects of graphene‐based biomaterials are discussed.

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“…The effects of the size and surface chemistry of different types of nanomaterials on their in vitro and in vivo behaviors have been studied by many research groups, which involves polymer micelles [16], polymer nanoparticles (NPs) [17, 18], dendrimers [19, 20], silica NPs [21], gold NPs [22, 23], graphene oxide [24], etc. However, to date, only a small number of studies have involved the shape effects of nanomaterials on their biological performance, because it is very difficult to control the nanomaterial shape at will, especially for polymer nanomaterials.…”

Section: Introductionmentioning

confidence: 99%

Shape Effects of Cylindrical versus Spherical Unimolecular Polymer Nanomaterials on in Vitro and in Vivo Behaviors

Zhang

Liu

et al. 2019

Research

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To date, how the shape of nanomaterials influences their biological properties is poorly understood, due to the insufficient controllability of current preparative methods, especially in the shape and size of nanomaterials. In this paper, we achieved the precise syntheses of nanoscale unimolecular cylindrical polymer brushes (CPBs) and spherical polymer nanoparticles (SPNPs) with the same volume and surface chemistry, which ensured that shape was essentially the only variable when their biological performance was compared. Accurate shape effects were obtained. Impressively, the CPBs had remarkable advantage in tissue penetration over the SPNPs. The CPBs also exhibited higher cellular uptake and rapider body clearance than the SPNPs, whereas the SPNPs had longer blood circulation time, rapider tumor vascular extravasation, and higher tumor accumulation than the CPBs. Additionally, this work also provided a controllable synthesis strategy for nanoscale unimolecular SPNPs by integrating 21 CPBs to a β-cyclodextrin core, whose diameter in dry state could be up to 45 nm.

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Visualization of size-dependent tumour retention of PEGylated nanographene oxide via SPECT imaging

Abstract: Sub-50 nm usNGO–PEG was confirmed to be the favorable size for faster and higher cellular uptake and efficient tumor accumulation than over-50 nm NGO–PEG.

Cited by 21 publications

References 50 publications

Radiolabelling of nanomaterials for medical imaging and therapy

Radiolabelling of nanomaterials for medical imaging and therapy

Graphene and Graphene‐Based Materials in Biomedical Science

Shape Effects of Cylindrical versus Spherical Unimolecular Polymer Nanomaterials on in Vitro and in Vivo Behaviors

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