Visualization of spatial and temporal temperature distributions with magnetic particle imaging for liver tumor ablation therapy

Salamon, Johannes; Dieckhoff, Jan; Kaul, Michael; Jung, Caroline; Adam, Gerhard; Möddel, Martin; Knopp, Tobias; Draack, Sebastian; Ludwig, Frank; Ittrich, Harald

doi:10.1038/s41598-020-64280-1

Cited by 38 publications

(27 citation statements)

References 35 publications

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“…Last but not least, the technology for non-invasively measuring and monitoring the temperature during the treatment process to avoid unexpected heating in healthy tissues is another challenge in magnetic hyperthermia. Some techniques such as magnetic [44,45] and ultrasound [46] based methods have already been proposed as potential candidates for this purpose.…”

Section: Discussionmentioning

confidence: 99%

Theoretical Analysis for Using Pulsed Heating Power in Magnetic Hyperthermia Therapy of Breast Cancer

Cao

Hadadian

et al. 2021

IJMS

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In magnetic hyperthermia, magnetic nanoparticles (MNPs) are used to generate heat in an alternating magnetic field to destroy cancerous cells. This field can be continuous or pulsed. Although a large amount of research has been devoted to studying the efficiency and side effects of continuous fields, little attention has been paid to the use of pulsed fields. In this simulation study, Fourier’s law and COMSOL software have been utilized to identify the heating power necessary for treating breast cancer under blood flow and metabolism to obtain the optimized condition among the pulsed powers for thermal ablation. The results showed that for small source diameters (not larger than 4 mm), pulsed powers with high duties were more effective than continuous power. Although by increasing the source domain the fraction of damage caused by continuous power reached the damage caused by the pulsed powers, it affected the healthy tissues more (at least two times greater) than the pulsed powers. Pulsed powers with high duty (0.8 and 0.9) showed the optimized condition and the results have been explained based on the Arrhenius equation. Utilizing the pulsed powers for breast cancer treatment can potentially be an efficient approach for treating breast tumors due to requiring lower heating power and minimizing side effects to the healthy tissues.

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Section: Discussionmentioning

confidence: 99%

Theoretical Analysis for Using Pulsed Heating Power in Magnetic Hyperthermia Therapy of Breast Cancer

Cao

Hadadian

et al. 2021

IJMS

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“…MPI allows the detection of inflammation through MNPs with a higher specificity and SNR. Ferucarbotran is currently considered the standard MPI agent due to its commercial availability and excellent signal properties 20,21 . Uptake of MNPs in AAAs has previously been investigated 22 and imaged with MRI in murine model as well as in human patients 10,16,23 .…”

Section: Discussionmentioning

confidence: 99%

Ex vivo magnetic particle imaging of vascular inflammation in abdominal aortic aneurysm in a murine model

Mangarova

Brangsch

Mohtashamdolatshahi

et al. 2020

Sci Rep

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Abdominal aortic aneurysms (AAAs) are currently one of the leading causes of death in developed countries. Inflammation is crucial in the disease progression, having a substantial impact on various determinants in AAAs development. Magnetic particle imaging (MPI) is an innovative imaging modality, enabling the highly sensitive detection of magnetic nanoparticles (MNPs), suitable as surrogate marker for molecular targeting of vascular inflammation. For this study, Apolipoprotein E-deficient-mice underwent surgical implantation of osmotic minipumps with constant Angiotensin II infusion. After 3 and 4 weeks respectively, in-vivo-magnetic resonance imaging (MRI), ex-vivo-MPI and ex-vivo-magnetic particle spectroscopy (MPS) were performed. The results were validated by histological analysis, immunohistology and laser ablation-inductively coupled plasma-mass spectrometry. MR-angiography enabled the visualization of aneurysmal development and dilatation in the experimental group. A close correlation (R = 0.87) with histological area assessment was measured. Ex-vivo-MPS revealed abundant iron deposits in AAA samples and ex-vivo histopathology measurements were in good agreement (R = 0.76). Ex-vivo-MPI and MPS results correlated greatly (R = 0.99). CD68-immunohistology stain and Perls'-Prussian-Blue-stain confirmed the colocalization of macrophages and MNPs. This study demonstrates the feasibility of ex-vivo-MPI for detecting inflammation in AAA. The quantitative ability for mapping MNPs establishes MPI as a promising tool for monitoring inflammatory progression in AAA in an experimental setting. Cardiovascular diseases are currently one of the leading causes of death in the Western world. An abdominal aortic aneurysm (AAA) is defined as a weakening and dilatation of the abdominal aorta, prevailing in the infrarenal portion of the artery. The prevalence of AAA has been on the rise during the last decades as a result of demographic ageing, screening programs and improved clinical imaging techniques 1. The main risk of undetected, asymptomatic aneurysms is progressive expansion, followed by rupture, hemorrhage and death in approximately 80% of the cases 2. The development of AAA involves inflammation as a fundamental process. Chronic inflammation is characterized by the infiltration of inflammatory cell types, mainly macrophages and monocytes in the thrombus and throughout all layers of the aortic wall 3. These cells release several proteolytic enzymes such as matrix metalloproteinases, cytokines and oxidation-derived free radicals, leading to vascular smooth muscle cell apoptosis and degradation of the aortic tunica media 3. In AAA, elastolysis as a result of the

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“…Following the same idea, magnetic nanoparticles could be released into the groundwater flow field and their movement along the flowpath would generate currents, which could be monitored with ERT monitoring arrays. This is a new approach that derives from magnetic particle imaging (MPI), which is an emerging noninvasive tomographic technique that directly detects superparamagnetic nanoparticle tracers in medical science (Vogel et al 2019; Salamon et al 2020). Currently, it is used in medical research to measure the 3D location and concentration of nanoparticles.…”

Section: Discussion: Requirements For Valid Laboratory‐scale Karst Momentioning

confidence: 99%

Review of Laboratory Scale Models of Karst Aquifers: Approaches, Similitude, and Requirements

Mohammadi¹,

Illman

Field

2020

Groundwater

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This review focuses on investigations of groundwater flow and solute transport in karst aquifers through laboratory scale models (LSMs). In particular, LSMs have been used to generate new data under different hydraulic and contaminant transport conditions, testing of new approaches for site characterization, and providing new insights into flow and transport processes through complex karst aquifers. Due to the increasing need for LSMs to investigate a wide range of issues, associated with flow and solute migration karst aquifers this review attempts to classify, and introduce a framework for constructing a karst aquifer physical model that is more representative of field conditions. The LSMs are categorized into four groups: sand box, rock block, pipe/fracture network, and pipe‐matrix coupling. These groups are compared and their advantages and disadvantages highlighted. The capabilities of such models have been extensively improved by new developments in experimental methods and measurement devices. Newer technologies such as 3D printing, computed tomography scanning, X‐rays, nuclear magnetic resonance, novel geophysical techniques, and use of nanomaterials allow for greater flexibilities in conducting experiments. In order for LSMs to be representative of karst aquifers, a few requirements are introduced: (1) the ability to simulate heterogeneous distributions of karst hydraulic parameters, (2) establish Darcian and non‐Darcian flow regimes and exchange between the matrix and conduits, (3) placement of adequate sampling points and intervals, and (4) achieving some degree of geometric, kinematic, and dynamic similitude to represent field conditions.

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Visualization of spatial and temporal temperature distributions with magnetic particle imaging for liver tumor ablation therapy

Cited by 38 publications

References 35 publications

Theoretical Analysis for Using Pulsed Heating Power in Magnetic Hyperthermia Therapy of Breast Cancer

Theoretical Analysis for Using Pulsed Heating Power in Magnetic Hyperthermia Therapy of Breast Cancer

Ex vivo magnetic particle imaging of vascular inflammation in abdominal aortic aneurysm in a murine model

Review of Laboratory Scale Models of Karst Aquifers: Approaches, Similitude, and Requirements

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