Visualization of therapeutic intervention for acute liver injury using low-intensity pulsed ultrasound-responsive phase variant nanoparticles

Abstract

Acute liver injury (ALI) is a highly fatal condition characterized by sudden massive necrosis of liver cells, inflammation, and impaired coagulation function. Currently, the primary clinical approach for managing ALI...

Ultrasound-Responsive Nanodelivery System of GPC3-Targeting and Sonosensitizer for Visualized Hepatocellular Carcinoma Therapy

“…The GC-NBs were synthesized by a lipid thin film and a simple facile acoustic-emulsification method. 30 In brief, DPPC, DPPE-mPEG2000, DSPE-PEG2000-biotin, DC-Chol, and Ce6 were mixed with absolute ethanol at a mass ratio of 5:1:1:0.5:0.3 and then transferred to a rotary evaporator under vacuum at 40 °C for 1 h to form a homogeneous dark lipid film. Subsequently, 3 mL of PBS was added to the bottle of the lipid mixture for hydration.…”