Visualization of thermal washout due to spatiotemporally heterogenous perfusion in the application of a model-based control algorithm for MR-HIFU mediated hyperthermia

Sebeke, Lukas; Rademann, Pia; Maul, Alexandra C.; Yeo, Sin Yuin; Gómez, Juan Daniel Castillo; Deenen, D.A.; Schmidt, Patrick; Jager, Bram de; Heemels, W.P.M.H.; Grüll, Holger; Heijman, Edwin

doi:10.1080/02656736.2021.1933616

Cited by 11 publications

(12 citation statements)

References 90 publications

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“…A novel approach based on induction of hyperthermia by scanning a high intensity focused ultrasound beam through the tumor volume is under development, but its use in humans needs to be tested. 51 Reliable hyperthermia delivery also requires real time temperature monitoring using minimally invasive temperature probes Review inserted in the vagina/cervix, bladder, and rectum. Non-invasive MRI based thermometry is under development, but its accuracy is presently still strongly limited by motion artifacts, and about half of the patients do not fit into the small bore of the hybrid MRI guided locoregional hyperthermia device.…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

“…Radiative locoregional hyperthermia devices are currently optimal for achieving therapeutic temperatures in deep seated tumors, such as in cervical cancer. A novel approach based on induction of hyperthermia by scanning a high intensity focused ultrasound beam through the tumor volume is under development, but its use in humans needs to be tested 51. Reliable hyperthermia delivery also requires real time temperature monitoring using minimally invasive temperature probes inserted in the vagina/cervix, bladder, and rectum.…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

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The role of hyperthermia in the treatment of locally advanced cervical cancer: a comprehensive review

IJff

Crezee

Oei

et al. 2022

Int J Gynecol Cancer

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Radiotherapy with cisplatin (chemoradiation) is the standard treatment for women with locally advanced cervical cancer. Radiotherapy with deep hyperthermia (thermoradiation) is a well established alternative, but is rarely offered as an alternative to chemoradiation, particularly for patients in whom cisplatin is contraindicated. The scope of this review is to provide an overview of the biological rationale of hyperthermia treatment delivery, including patient workflow, and the clinical effectiveness of hyperthermia as a radiosensitizer in the treatment of cervical cancer. Hyperthermia is especially effective in hypoxic and nutrient deprived areas of the tumor where radiotherapy is less effective. Its radiosensitizing effectiveness depends on the temperature level, duration of treatment, and the time interval between radiotherapy and hyperthermia. High quality hyperthermia treatment requires an experienced team, adequate online adaptive treatment planning, and is preferably performed using a phased array radiative locoregional hyperthermia device to achieve the optimal thermal dose effect. Hyperthermia is well tolerated and generally leads to only mild toxicity, such as patient discomfort. Patients in whom cisplatin is contraindicated should therefore be referred to a hyperthermia center for thermoradiation.

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Section: Future Perspectives and Conclusionmentioning

confidence: 99%

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

The role of hyperthermia in the treatment of locally advanced cervical cancer: a comprehensive review

IJff

Crezee

Oei

et al. 2022

Int J Gynecol Cancer

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“…They used the bio‐heat transfer equation (BHTE) model and temperature information acquired with invasive probes 25 . For high‐intensity focused ultrasound (HIFU), several studies employed filtering in combination with MR thermometry to improve the temperature estimation 26,27 . Roujol et al 28 .…”

Section: Introductionmentioning

confidence: 99%

“…25 For high-intensity focused ultrasound (HIFU), several studies employed filtering in combination with MR thermometry to improve the temperature estimation. 26,27 Roujol et al 28 employed a Kalman filter combined with MR thermometry and showed a threefold accuracy improvement for temperature estimation when heating a phantom and a porcine kidney. Zhang et al 29 and Schmitt et al 30 have shown combining Kalman filtering with MR thermometry to improve the temperature monitoring accuracy on patient data using HIFU.…”

Section: Introductionmentioning

confidence: 99%

POD–Kalman filtering for improving noninvasive 3D temperature monitoring in MR‐guided hyperthermia

et al. 2022

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Background: During resonance frequency (RF) hyperthermia treatment, the temperature of the tumor tissue is elevated to the range of 39-44 • C. Accurate temperature monitoring is essential to guide treatments and ensure precise heat delivery and treatment quality. Magnetic resonance (MR) thermometry is currently the only clinical method to measure temperature noninvasively in a volume during treatment. However, several studies have shown that this approach is not always sufficiently accurate for thermal dosimetry in areas with motion, such as the pelvic region. Model-based temperature estimation is a promising approach to correct and supplement 3D online temperature estimation in regions where MR thermometry is unreliable or cannot be measured. However, complete 3D temperature modeling of the pelvic region is too complex for online usage.Purpose: This study aimed to evaluate the use of proper orthogonal decomposition (POD) model reduction combined with Kalman filtering to improve temperature estimation using MR thermometry. Furthermore, we assessed the benefit of this method using data from hyperthermia treatment where there were limited and unreliable MR thermometry measurements. Methods: The performance of POD-Kalman filtering was evaluated in several heating experiments and for data from patients treated for locally advanced cervical cancer. For each method, we evaluated the mean absolute error (MAE) concerning the temperature measurements acquired by the thermal probes,and we assessed the reproducibility and consistency using the standard deviation of error (SDE). Furthermore, three patient groups were defined according to susceptibility artifacts caused by the level of intestinal gas motion to assess if the POD-Kalman filtering could compensate for missing and unreliable MR thermometry measurements. Results: First, we showed that this method is beneficial and reproducible in phantom experiments. Second, we demonstrated that the combined method improved the match between temperature prediction and temperature acquired by intraluminal thermometry for patients treated for locally advanced cervical cancer. Considering all patients, the POD-Kalman filter improved MAE by 43% (filtered MR thermometry = 1.29 • C, POD-Kalman filtered temperature = 0.74 • C). Moreover, the SDE was improved by 47% (filtered MRThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…These verification measurements are aimed at improving the translation of hyperthermia treatment planning (HTP) settings into the clinical routine. While quality assurance measurements make HTP a more reliable tool to ensure target conformal electromagnetic field energy delivery, the uncertainties in tissue electromagnetic and thermal properties affect the reliability of the model based predicted temperatures [ 19 , 20 , 21 ]. Hence, detailed temperature measurements, both in the target region and healthy tissues, are required to assess the true temperatures achieved and to enable dynamic adaptation of the power distribution for maximizing the applied thermal dose.…”

Section: Introductionmentioning

confidence: 99%

Experimental Validation of the MRcollar: An MR Compatible Applicator for Deep Heating in the Head and Neck Region

Sümser

Drizdal

Bellizzi

et al. 2021

Cancers

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Clinical effectiveness of hyperthermia treatments, in which tumor tissue is artificially heated to 40–44 °C for 60–90 min, can be hampered by a lack of accurate temperature monitoring. The need for noninvasive temperature monitoring in the head and neck region (H&N) and the potential of MR thermometry prompt us to design an MR compatible hyperthermia applicator: the MRcollar. In this work, we validate the design, numerical model, and MR performance of the MRcollar. The MRcollar antennas have low reflection coefficients (<−15 dB) and the intended low interaction between the individual antenna modules (<−32 dB). A 10 °C increase in 3 min was reached in a muscle-equivalent phantom, such that the specifications from the European Society for Hyperthermic Oncology were easily reached. The MRcollar had a minimal effect on MR image quality and a five-fold improvement in SNR was achieved using the integrated coils of the MRcollar, compared to the body coil. The feasibility of using the MRcollar in an MR environment was shown by a synchronous heating experiment. The match between the predicted SAR and measured SAR using MR thermometry satisfied the gamma criteria [distance-to-agreement = 5 mm, dose-difference = 7%]. All experiments combined show that the MRcollar delivers on the needs for MR—hyperthermia in the H&N and is ready for in vivo investigation.

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Visualization of thermal washout due to spatiotemporally heterogenous perfusion in the application of a model-based control algorithm for MR-HIFU mediated hyperthermia

Cited by 11 publications

References 90 publications

The role of hyperthermia in the treatment of locally advanced cervical cancer: a comprehensive review

The role of hyperthermia in the treatment of locally advanced cervical cancer: a comprehensive review

POD–Kalman filtering for improving noninvasive 3D temperature monitoring in MR‐guided hyperthermia

Experimental Validation of the MRcollar: An MR Compatible Applicator for Deep Heating in the Head and Neck Region

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