Visualized Analysis of Heavy Ion Radiotherapy: Development, Barriers and Future Directions

Jin, Yuanchang; Li, Jingwen; Zhang, Na; Guo, Kangle; Zhang, Qiuning; Wang, Xiaohu; Yang, Kehu

doi:10.3389/fonc.2021.634913

Cited by 7 publications

(6 citation statements)

References 64 publications

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“…The theme of a paper is reflected in the keywords, and by analyzing them, researchers can get an idea of the topic of the article ( 23 ). The presence of two keywords from a certain field in the same article, called co-occurrence, reflected that there is some internal relationship between them, and the more they appear, the closer the relatedness is ( 24 ).…”

Section: Resultsmentioning

confidence: 99%

Evolutions in the management of non-small cell lung cancer: A bibliometric study from the 100 most impactful articles in the field

et al. 2022

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ObjectiveThe study was designed to explore the evolution of non-small cell lung cancer (NSCLC) management in the last 20 years.MethodsThe top 100 most-cited papers on NSCLC treatment were retrieved from the Web of Science Core Collection database. R and VOSviewer were used to extract bibliographic information, including the year of publication, countries/regions, institutions, authors, journals, keywords, impact factor, and total citations. The topic and type of papers were checked independently by authors. Bibliometric analysis was conducted and visualized with R, CiteSpace, Excel and VOSviewer to identify output dynamics, research forces, topics, hotspots, and frontiers in the field.ResultsThe average citation of each retrieved top 100 most-cited NSCLC management papers was 1,725 (range: 615-7,340). Fifty-seven corresponding authors were from the United States. This country contributed the most papers (n=76), followed by Germany (n=34), France (n=33), and South Korea (n=32). The top contributors were Paz-Ares L. (n=12) and Reck M. (n=12). The Memorial Sloan Kettering Cancer Center published the largest number of papers (n=20). There were two significant citation paths, indicating publications in medicine/medical/clinical journals primarily cited journals in molecular/biology/genetics fields, partly cited health/nursing/medicine fields. Top-cited papers mainly came from the New England Journal of Medicine (n=33, citations=80,427), followed closely by the Journal of Clinical Oncology (n=28, citations=32,408). “Chemotherapy” (n=36) was the keyword with the greatest frequency of co-occurrence. “Open-label” was the keyword with the strongest burst strength (=4.01), followed by “nivolumab” (=3.85), “blockade” (=2.86), and “efficacy” (=2.85).ConclusionsThe United States as a nation and the Memorial Sloan Kettering Cancer Center as an institute contributed the most to this field. The New England Journal of Medicine is the most eye-catching journal. Hotspots of NSCLC management have almost undergone an evolution from chemotherapy and radiotherapy to targeted therapy to immunotherapy. Molecular/biological/genetic fields become the main research base for NSCLC treatment. Immunotherapy and combination therapy are research frontiers.

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Section: Resultsmentioning

confidence: 99%

Evolutions in the management of non-small cell lung cancer: A bibliometric study from the 100 most impactful articles in the field

et al. 2022

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“…Especially in the past two decades, space technology has advanced rapidly, allowing humans to explore outer space, but at the same time, the chance of human exposure to heavy-ion radiation hazards has increased greatly ( 29, 30 ). Research on the protection against heavy-ion radiation, a high-LET radiation, has been one of the hot topics in the life sciences, especially in radiation biology and radiotherapy research ( 31 ). Radiation-induced reactive oxygen species are thought to damage cellular DNA, causing single- and double-stranded DNA breaks that lead to chromosomal abnormalities and cell death ( 32, 33 ).…”

Section: Discussionmentioning

confidence: 99%

TLR4 Agonist MPLA Ameliorates Heavy-Ion Radiation Damage via Regulating DNA Damage Repair and Apoptosis

Liu¹,

Wang²,

et al. 2023

Radiation Research

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Heavy-ion radiation received during radiotherapy as well as the heavy-ion radiation received during space flight are equally considered harmful. Our previous study showed that TLR4 low toxic agonist, monophosphoryl lipid A (MPLA), alleviated radiation injury resulting from exposure to low-LET radiation. However, the role and mechanism of MPLA in heavy-ion-radiation injury are unclear. This study aimed to investigate the role of MPLA on radiation damage. Our data showed that MPLA treatment alleviated the heavy-ion-induced damage to microstructure and the spleen and testis indexes. The number of karyocytes in the bone marrow from the MPLA-treated group was higher than that in the irradiated group. Meanwhile, western blotting analysis of intestine proteins showed that pro-apoptotic proteins (cleaved-caspase3 and Bax) were downregulated while anti-apoptotic proteins (Bcl-2) were upregulated in the MPLA-treated group. Our in vitro study demonstrated that MPLA significantly improved cell proliferation and inhibited cell apoptosis after irradiation. Moreover, immunofluorescence staining and quantification of nucleic γ-H2AX and 53BP1 foci also suggested that MPLA significantly attenuated cellular DNA damage repair. Collectively, the above evidence supports the potential ability of MPLA to protect against heavy-ion-radiation injury by inhibiting apoptosis and alleviating DNA damage in vivo and vitro, which could be a promising medical countermeasure for the prevention of heavy-ion-radiation injury.

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“…Co-citation analysis means that 2 documents are cited by a third document at the same time, and the 2 documents constitute a co-citation relationship. [8,17] Through the co-citation of documents, we can explore the evolution of a particular field.…”

Section: Methodsmentioning

confidence: 99%

“…With the development of computer science and informatics, bibliometrics provides a new perspective for sorting out the development context and research trends of a certain field while overcoming the shortcomings of narrative reviews. Bibliometrics has certain applications in the field of tumor radiotherapy, mainly focused on heavy ion radiotherapy, [8] intraoperative radiotherapy, [9] lung cancer radiotherapy, [10] head and neck cancer radiotherapy, [11] and radiotherapy and male infertility [12] and other tumors clinical literature metrology research. However, tumor radiotherapy technology-related metrology research remains in the vacuum zone.…”

Section: Introductionmentioning

confidence: 99%

Visual analysis of image-guided radiation therapy based on bibliometrics: A review

Yuan

Shen

2023

Medicine

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Radiation therapy plays an important role in tumor treatment. The development of image-guided radiation therapy (IGRT) technology provides a strong guarantee for precise radiation therapy of tumors. However, bibliometric studies on IGRT research have rarely been reported. This study uses literature collected from the Web of Science during 1987 to 2021 as a sample and uses the bibliometric method to reveal the current research status, hotspots, and development trends in IGRT. Based on 6407 papers published from the Web of Science during 1987 to 2021, we utilized Microsoft Excel 2007 and cite space software to perform statistical analysis and visualization of IGRT. A total of 6407 articles were included, this area of IGRT has gone through 4 stages: budding period, growth period, outbreak period, and stationary period. The research category is mainly distributed in Radiology Nuclear Medicine Medical Imaging, which intersects with the research categories of Materials, Physics, and Mathematics. Yin FF, Tanderup K, and Sonke JJ are highly productive scholars who are active in IGRT research, while Jaffray DA, van Herk M and Guckenberger M are authors with high impact in this field. The team of scholars has close cooperation within the team and weak cooperation among teams. The League of European Research Universities, University of Texas System, University of Toronto, and Princess Margaret Cancer are the main research institutions in this field. The United States has the most research literature, followed by China and Germany. Six thousand four hundred seven articles are distributed in 712 journals, and the top 3 journals are Med Phys, Int J Radiat Oncol, and Radiather Oncol. Precise registration, intelligence, magnetic resonance guidance, and deep learning are current research hotspots. These results demonstrate that the research in this field is relatively mature and fruitful in the past 35 years, providing a solid theoretical basis and practical experience for precision radiotherapy.

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Visualized Analysis of Heavy Ion Radiotherapy: Development, Barriers and Future Directions

Cited by 7 publications

References 64 publications

Evolutions in the management of non-small cell lung cancer: A bibliometric study from the 100 most impactful articles in the field

Evolutions in the management of non-small cell lung cancer: A bibliometric study from the 100 most impactful articles in the field

TLR4 Agonist MPLA Ameliorates Heavy-Ion Radiation Damage via Regulating DNA Damage Repair and Apoptosis

Visual analysis of image-guided radiation therapy based on bibliometrics: A review

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