Visualized intravesical floating hydrogel encapsulating vaporized perfluoropentane for controlled drug release

Zhu, Guanchen; Zhang, Yifan; Zhao, Xiaozhi; Lian, Huibo; Wang, Wei; Wang, Haoran; Wu, Jinhui; Hu, Yiqiao; Guo, Hongqian

doi:10.3109/10717544.2015.1101791

Cited by 36 publications

(21 citation statements)

References 21 publications

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“…To prolong residence time in the bladder, floating systems have also been proposed ( Kolawole et al, 2017 ; Lin et al, 2014a , Lin et al, 2014b ; Zhu et al, 2016 ). These exploit buoyancy of low-density dosage forms in urine, thus resisting excretion through the urethra.…”

Section: Strategies To Improve the Pharmacological Therapy Of Urinary Bladder Diseasesmentioning

confidence: 99%

Intravesical drug delivery approaches for improved therapy of urinary bladder diseases

Palugan

Cerea

Cirilli

et al. 2021

International Journal of Pharmaceutics: X

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Diseases of the urinary bladder have high incidence rates and burden healthcare costs. Their pharmacological treatment involves systemic and local drug administration. The latter is generally accomplished through instillation of liquid formulations and requires repeated or long-term catheterization that is associated with discomfort, inflammation and bacterial infections. Consequently, compliance issues and dropouts are frequently reported. Moreover, instilled drugs are progressively diluted as the urine volume increases and rapidly excreted. When penetration of drugs into the bladder wall is needed, the poor permeability of the urothelium has also to be accounted for. Therefore, much research effort is spent to overcome these hurdles, thereby improving the efficacy of available therapies. Particularly, indwelling delivery systems suited for i) insertion into the bladder through the urethra, ii) intra-organ retention and prolonged release for the desired time lapse, iii) final elimination, either spontaneous or by manual removal, have been proposed to reduce the number of catheterization procedures and reach higher drug levels at the target site. Vesical retention of such devices is allowed by the relevant expansion that can either be triggered from the outside or achieved exploiting elastic and purposely 4D printed shape memory materials. In this article, the main rationales and strategies for improved intravesical delivery are reviewed.

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Section: Strategies To Improve the Pharmacological Therapy Of Urinary Bladder Diseasesmentioning

confidence: 99%

Intravesical drug delivery approaches for improved therapy of urinary bladder diseases

Palugan

Cerea

Cirilli

et al. 2021

International Journal of Pharmaceutics: X

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“…In recent times, the use of nanomaterials as drug delivery systems has become an emerging technique in the field of nanomedicine. [1] In the current decade, numerous nanoplatform such as aptamer, [2] nanoparticles, [3][4] polymer, [5] vesicles, [6] dendrimers, [7][8] micelles, [9] and hydrogel [10][11][12] have been designed for drug delivery.I tis worth mentioning that gold nanoparticles have been used as an excellent transporter of anticancer drugs because of their nontoxicity,b iocompatibility andi nertness. [13] Due to highs urface area to volumer atios, gold nanoparticles were functionalized with multiple ligands, which made them excellent candidates for variousa pplication such as drug delivery,i maging ands ensing.…”

Section: Introductionmentioning

confidence: 99%

“…[13] Due to highs urface area to volumer atios, gold nanoparticles were functionalized with multiple ligands, which made them excellent candidates for variousa pplication such as drug delivery,i maging ands ensing. [14][15][16][17] Other than reported nano and sub-nanostructured molecules and materials, [2][3][4][5][6][7][8][9][10][11][12][13][14] micro scale architectures have been reported for drug delivery purpose in the last decade. [18][19][20][21] The design strategies for microstructures based on extracellular matrix finely controlled at microscale level, [18] light driven pathways, [19] hot punching of polymericm aterials, [20] and botanical inspired4 Dp rinting of hydrogels [21] were responsible for the successful demonstration of drug delivery to the target.…”

Section: Introductionmentioning

confidence: 99%

“…Other than reported nano and sub‐nanostructured molecules and materials, [2–14] micro scale architectures have been reported for drug delivery purpose in the last decade [18–21] . The design strategies for microstructures based on extracellular matrix finely controlled at microscale level, [18] light driven pathways, [19] hot punching of polymeric materials, [20] and botanical inspired 4D printing of hydrogels [21] were responsible for the successful demonstration of drug delivery to the target.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Selective Release of Doxorubicin from Cucurbit[8]uril Stabilized Gold Supra‐Pyramid Host at pH of Small Intestine

Saini

Ghosh

Kumar

et al. 2020

Chemistry A European J

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Gold supra-pyramid structures wereo btained by the addition of acidic solution of cucurbit[8]uril(CB[8]) to an aqueous solution of citrate stabilized gold nanoparticles (AuNP). The reactionr esulted in the precipitation of suprapyramid from the solution after just 1min of shaking. Microscopic images confirmed formation of the supra-pyramid. The stepwise structural transformation towards the suprapyramid was examined with variable concentrations of CB[8] to AuNP solution. Anionic counterp arts of thesea cids (Br À , NO 3 À ,S O 4 2À and Cl À)c ontrolled the size of the synthesized supra-pyramids. These supra-pyramid hosts showed uptake of three anticancer drugs:o ral drugs etoposide, prednisolone and intravenousd rug doxorubicin. Releases of drugs from these hosts were emulated at acidic stomach pH, basic small intestinal pH and in the presence of human serum albumin (HSA). The specific release of doxorubicin was confirmed at small intestinal pH 7.4. Poor release of drugs in presence of CB[8] specific guest 1-adamantanamine confirmed the role of the supra-pyramid as the exclusive host. The release of doxorubicin from the supra-pyramid at pH 7.4 was confirmed by fluorescencem icroscopici maging with prostate cancer DU-145 cell line.

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“…The main limitations of these methods rely on the invasion and destruction for the samples in addition to the sample quantity requirements because of the lack of real-time in vivo tracking objectively. Noninvasive continuous tracking is a potential trend for the investigation of the in vivo drug delivery process simultaneously (Tzu-Yin et al, 2013 ; Brudno et al, 2014 ; Lin et al, 2016 ; Zhu et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive porphyrin-incorporated hydrogel with four-arm PEG-PCL copolymer (II): doxorubicin loaded hydrogel as a dual fluorescent drug delivery system for simultaneous imaging tracking in vivo

et al. 2017

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Visualization of a drug delivery system could reveal the pharmacokinetic properties, which is essential for the design of a novel drug delivery system. In vivo optical imaging offers an advanced tool to monitor the drug release process and the therapeutic effect by the combination of fluorescence imaging and bioluminescence imaging. Multispectral fluorescence imaging can separate the drug and the carrier without interference. Herein, a dual fluorescent anti-tumor drug delivery system was monitored with the doxorubicin-loaded hydrogel to further explore the application of the porphyrin-incorporated hydrogel with four-arm PEG-PCL copolymer as a drug carrier, based on the beneficial fluorescence and good biocompatibility of the porphyrin incorporated hydrogel. Using nude mice bearing luciferase expressed hepatic tumor as models, the whole process from the drug delivery to the tumor therapeutic effects were real time visualized simultaneously after administration at interval from 0 to 18 d. The imaging results suggest that the fluorescence signals of the drug and the carrier can be separated and unmixed from the drug-loaded hydrogel successfully, avoiding the interference of the fluorescence signals. The tumor growth or inhibition can be real time tracked and analyzed quantitatively by bioluminescence imaging. Noninvasive continuous tracking the in vivo drug delivery process simultaneously is a potential trend for the precise drug delivery and treatment.

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Visualized intravesical floating hydrogel encapsulating vaporized perfluoropentane for controlled drug release

Cited by 36 publications

References 21 publications

Intravesical drug delivery approaches for improved therapy of urinary bladder diseases

Intravesical drug delivery approaches for improved therapy of urinary bladder diseases

Selective Release of Doxorubicin from Cucurbit[8]uril Stabilized Gold Supra‐Pyramid Host at pH of Small Intestine

Thermosensitive porphyrin-incorporated hydrogel with four-arm PEG-PCL copolymer (II): doxorubicin loaded hydrogel as a dual fluorescent drug delivery system for simultaneous imaging tracking in vivo

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