Visualizing breast cancer using the Twente photoacoustic mammoscope: What do we learn from twelve new patient measurements?

Heijblom, Michelle; Piras, Daniele; Xia, Wenfeng; Hespen, Johan C. G. van; Klaase, J.M.; Engh, Frank M. van den; Leeuwen, Ton G. van; Steenbergen, Wiendelt; Manohar, Srirang

doi:10.1364/oe.20.011582

Cited by 179 publications

(170 citation statements)

References 52 publications

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“…As a result, hand-held optoacoustic probes have been attempted to image parts accessible from outside of the body 11,12 while endoscopic systems are used to provide images from within the body by inserting them via natural orifices 13 . Some low absorbing parts of human body, such as female breast, are also accessible by tomographic optoacoustic scanners 14,15 . Of particular interest is the hand-held approach as it enables large versatility, similarly to ultrasonography.…”

Section: Introductionmentioning

confidence: 99%

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Deán‐Ben

Fehm

Razansky

2014

JoVE

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The exclusive combination of high optical contrast and excellent spatial resolution makes optoacoustics (photoacoustics) ideal for simultaneously attaining anatomical, functional and molecular contrast in deep optically opaque tissues. While enormous potential has been recently demonstrated in the application of optoacoustics for small animal research, vast efforts have also been undertaken in translating this imaging technology into clinical practice. We present here a newly developed optoacoustic tomography approach capable of delivering high resolution and spectrally enriched volumetric images of tissue morphology and function in real time. A detailed description of the experimental protocol for operating with the imaging system in both hand-held and stationary modes is provided and showcased for different potential scenarios involving functional and molecular studies in murine models and humans. The possibility for real time visualization in three dimensions along with the versatile handheld design of the imaging probe make the newly developed approach unique among the pantheon of imaging modalities used in today's preclinical research and clinical practice. Video LinkThe video component of this article can be found at

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Section: Introductionmentioning

confidence: 99%

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Deán‐Ben

Fehm

Razansky

2014

JoVE

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“…Fluence compensation is an important aspect of photoacoustic imaging that will be critical as the technique moves towards clinical use in large organs [7,31]. Since light can be attenuated an order of magnitude for every centimeter that it travels though tissue, quantitation of optical properties and spectrally derived chromophore concentrations are subject to large errors beyond 10 mm when using FBP and similar reconstruction techniques.…”

Section: Discussionmentioning

confidence: 99%

“…It is an excellent avenue for interrogating angiogenesis and blood content in highly aggressive tumors, and shows great potential for molecular imaging [5]. PAI and Photoacoustic Tomography (PAT) have been developing for many years in both clinical and preclinical regimes with applications in skin [6] and breast cancer [7,8], lymph node mapping [9][10][11], and endoscopy [12,13]. These technique relies on absorption of light to create contrast, a phenomenon that is governed by both tissue optical properties and light fluence.…”

Section: Introductionmentioning

confidence: 99%

Quantitative photoacoustic image reconstruction improves accuracy in deep tissue structures

Mastanduno¹,

Gambhir²

2016

Biomed. Opt. Express

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Photoacoustic imaging (PAI) is emerging as a potentially powerful imaging tool with multiple applications. Image reconstruction for PAI has been relatively limited because of limited or no modeling of light delivery to deep tissues. This work demonstrates a numerical approach to quantitative photoacoustic image reconstruction that minimizes depth and spectrally derived artifacts. We present the first time-domain quantitative photoacoustic image reconstruction algorithm that models optical sources through acoustic data to create quantitative images of absorption coefficients. We demonstrate quantitative accuracy of less than 5% error in large 3 cm diameter 2D geometries with multiple targets and within 22% error in the largest size quantitative photoacoustic studies to date (6cm diameter). We extend the algorithm to spectral data, reconstructing 6 varying chromophores to within 17% of the true values. This quantitiative PA tomography method was able to improve considerably on filtered-back projection from the standpoint of image quality, absolute, and relative quantification in all our simulation geometries. We characterize the effects of time step size, initial guess, and source configuration on final accuracy. This work could help to generate accurate quantitative images from both endogenous absorbers and exogenous photoacoustic dyes in both preclinical and clinical work, thereby increasing the information content obtained especially from deep-tissue photoacoustic imaging studies. Hahn, and A. G. Yodh, "In vivo reflectance measurement of optical properties, blood oxygenation and motexafin lutetium uptake in canine large bowels, kidneys and prostates," Phys. Med. Biol. 47(6), 857-873 (2002)

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“…During last decades, the field of biomedical imaging has witnessed an emerging technique called photoacoustics [1][2][3] that is making its way towards clinical applications. In photoacoustic imaging, a short pulse of light is absorbed by tissue chromophores, which induces a local instantaneous temperature rise.…”

Section: Introductionmentioning

confidence: 99%

Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging

Daoudi¹,

Berg²,

Rabot³

et al. 2014

Opt. Express

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Ultrasound and photoacoustics can be utilized as complementary imaging techniques to improve clinical diagnoses. Photoacoustics provides optical contrast and functional information while ultrasound provides structural and anatomical information. As of yet, photoacoustic imaging uses large and expensive systems, which limits their clinical application and makes the combination costly and impracticable. In this work we present and evaluate a compact and ergonomically designed handheld probe, connected to a portable ultrasound system for inexpensive, real-time dualmodality ultrasound/photoacoustic imaging. The probe integrates an ultrasound transducer array and a highly efficient diode stack laser emitting 130 ns pulses at 805 nm wavelength and a pulse energy of 0.56 mJ, with a high pulse repetition frequency of up to 10 kHz. The diodes are driven by a customized laser driver, which can be triggered externally with a high temporal stability necessary to synchronize the ultrasound detection and laser pulsing. The emitted beam is collimated with cylindrical micro-lenses and shaped using a diffractive optical element, delivering a homogenized rectangular light intensity distribution. The system performance was tested in vitro and in vivo by imaging a human finger joint.

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Visualizing breast cancer using the Twente photoacoustic mammoscope: What do we learn from twelve new patient measurements?

Cited by 179 publications

References 52 publications

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Quantitative photoacoustic image reconstruction improves accuracy in deep tissue structures

Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging

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