Visualizing dynamic interactions between mitochondria and lysosomes in living cells using novel pH-sensitive fluorescent probes in dual-channel

Li, Meng-Nan; Zhao, Jing-Yu; Wang, Wen-Li; Wang, Chang; Ge, Jian-Feng; Sun, Ru

doi:10.1016/j.snb.2024.135743

Sensors and Actuators B: Chemical

2024

DOI: 10.1016/j.snb.2024.135743

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Visualizing dynamic interactions between mitochondria and lysosomes in living cells using novel pH-sensitive fluorescent probes in dual-channel

Meng-Nan Li,

Jing-Yu Zhao,

Wen-Li Wang

et al.

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Cited by 9 publications

References 51 publications

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Diphenylbutadiene Fluorescent Analogues in Sub‐Cellular Imaging and Monitoring Mitophagy

Ghorpade,

Mansuri,

Kumar

et al. 2024

Chemistry An Asian Journal

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A series of donor‐acceptor (D‐π‐A) substituted diphenylbutadienes exhibiting solvatochromic emission and a large Stokes shift (100‐200 nm) were designed and synthesized for distinctive organelle labelling, enabling real‐time monitoring of organelle behaviour such as lysosomal dynamics, mitophagy monitoring, and stress responses. The morpholine‐substituted D‐A‐D diphenylbutadiene (M2) was employed to investigate selective imaging of lysosomes, the uptake of damaged mitochondria through mitophagy, and monitoring lysosomal viscosity or pH changes. Other diphenylbutadiene derivatives (M1, M3, M4) selectively accumulated in lipid droplets. All the synthesized derivatives demonstrated significant uptake in 5‐day post‐fertilization zebrafish larvae, with M2 showing maximum uptake in the enterocyte‐containing heart and intestinal regions, which include the lysosomes

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Diphenylbutadiene Fluorescent Analogues in Sub‐Cellular Imaging and Monitoring Mitophagy

Ghorpade,

Mansuri,

Kumar

et al. 2024

Chemistry An Asian Journal

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Recent advances in single fluorescent probes for monitoring dual organelles in two channels

Yang,

Yao,

et al. 2024

Smart Molecules

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Organelles are specialized areas where cells perform specific processes necessary for life and actively communicate with each other to keep the whole cell functioning. Disorders of the organelle networks are associated with multiple pathological processes. However, clearly and intuitively visualizing the highly dynamic interactions between ultrafine organelles is challenging. Fluorescence imaging technology provides opportunities due to the distinct advantages of facile, non‐invasiveness and dynamic detection, making it particularly well‐suited for applications in uncovering the mysterious veil of organelle interactions. Regrettably, the lack of ideal fluorescence agents has always been an obstacle in imaging the intricate behaviors of organelles. In this review, we provide a systematic discussion on the existing dual‐color and dual‐targetable molecular sensors used in monitoring organelle interactions, with a specific focus on their targeting strategies, imaging mechanisms and biological applications. Additionally, the current limitations and future development directions of dual‐targetable probes and dual‐emissives are briefly discussed. This review aims to provide guidance for researchers to develop more improved probes for studying organelle interactions in the biomedical field.

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A lysosome-targeted fluorescent probe for thiol detection in drug analysis and multiple biological systems

Liu,

Song,

et al. 2024

Anal Bioanal Chem

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Visualizing dynamic interactions between mitochondria and lysosomes in living cells using novel pH-sensitive fluorescent probes in dual-channel

Cited by 9 publications

References 51 publications

Diphenylbutadiene Fluorescent Analogues in Sub‐Cellular Imaging and Monitoring Mitophagy

Diphenylbutadiene Fluorescent Analogues in Sub‐Cellular Imaging and Monitoring Mitophagy

Recent advances in single fluorescent probes for monitoring dual organelles in two channels

A lysosome-targeted fluorescent probe for thiol detection in drug analysis and multiple biological systems

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