The process of designing a remedy for contaminated groundwater historically has not commonly included climate‐future, hydrologic, and biogeochemical aquifer characteristics. From experience, the remedy design process also has not consistently nor directly integrated or projected future hydrologic and biogeochemical effects of the human‐induced or developed environment—aka the anthropogenic influence—on potential remedy performance. The apparent practice of (1) not regularly assessing anthro‐influenced hydrological (termed here as anthrohydrology) or biogeochemical characteristics (collectively hydrobiogeochemistry) of a site and (2) rarely accounting for future climatic shifts as design factors in remedy design may be due, in part, to the general practice‐level view that groundwater remediation systems (whether in situ or ex situ) have seldom been anticipated to last more than a few years (or one or two decades at the most). Second, methods to reliably and quantitatively estimate site‐specific, climate‐future shifts in groundwater conditions using global and/or regional climate models and the resultant impacts on contaminant plume characteristics have not been readily available. The authors here suggest that while the concept of remedy design resilience and durability, within an envelope of climate change and anthropogenic influence, has been discussed in some technical circles as a component of “sustainable remediation,” we have found that direct application of these technical concepts in quantifiable terms remains rare. By incorporating the potential influence of future hydrobiogeochemical scenarios into remedy design, however, the design process could account for reasonable climate‐induced influence on the groundwater system for a given site. These scenarios could then be applied within the remedy selection process to assess performance durability under potentially changing hydrologic, biological, and chemical conditions.