Visuell evozierte Potentiale: methodische Probleme - Variation der Reizparameter

The Tübingen study of optic neuritis treatment was started in 1980 to apply new and sensitive tests for monitoring a potential therapeutical steroid effect on the course of acute optic neuritis. Visual evoked potentials were used to assess an effect of oral methylprednisolone in a randomized, controlled trial. Forty-eight patients with acute optic neuritis were treated orally either with methylprednisolone (100 mg per day initially, dosage reduction every 3 days; n = 15) or with thiamine (100 mg per day; n = 33) in the control group, 36 of them in a double-blind procedure. A comparison of the two treatment groups indicated that oral methylprednisolone resulted in a faster improvement in visual evoked potential latency in the initial phase (p = 0.015, 4 weeks after onset), but had no benefit after 12 weeks and 12 months. Follow-up showed different types of courses in the visual evoked potential latencies. The visual evoked potential latencies were correlated to other outcome variables, such as visual evoked potential amplitudes, visual acuity, Aulhorn flicker test and perimetry. We were able to handle nonmeasurable latencies in highly pathologic cases by means of ranks (taking into account censored observations).

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The effect of oral prednisolone on visual evoked potential latencies in acute optic neuritis monitored in a prospective, randomized, controlled study

Trauzettel‐Klosinski

Diener

Dietz

et al. 1995

Doc Ophthalmol

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Interrelations of Age, Sensory Functions, and Human Brain Signal Processing

Kügler

1999

The Journals of Gerontology Series A: Biological Sciences and M

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Disturbances of sensory functions may additionally impair cognitive functions in elderly persons. To delineate the impact of visual sensory functions on brain signal processing during normal aging from an electrophysiological perspective, we investigated 289 fit community-dwelling subjects (162 men [56%] and 127 women [44%]; age range, 18-98 years) by means of visual event-related P300 potentials. By taking age, visual acuity, and stimulus-dependent components of visual-evoked potentials (PVEPs) into account, we found age to be the single most important factor for P300 variability (partial F > 10.0, p < .0001 for all P300 parameters; stepwise regression analysis). Furthermore, both the N75 (partial F = 12.415) and P100 latencies (partial F = 4.850) of the PVEPs were independently correlated with the P300 latencies, whereas the P300 amplitudes revealed additional correlations with the P100 amplitudes (partial F = 8.576; p < .0001, for all). Sex, however, did not influence these age-related P300 changes. Aging itself accounts for the largest proportion of variability in human brain signal processing as reflected by P300 potentials. Visual sensory functions, however, also provide an independent, but minor, contribution to P300 variability. Therefore, it seems prudent to take parameters of sensory functions into account especially for clinical P300 applications in the elderly population.

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Visuell evozierte Potentiale: methodische Probleme - Variation der Reizparameter

Cited by 2 publications

References 6 publications

The effect of oral prednisolone on visual evoked potential latencies in acute optic neuritis monitored in a prospective, randomized, controlled study

The effect of oral prednisolone on visual evoked potential latencies in acute optic neuritis monitored in a prospective, randomized, controlled study

Interrelations of Age, Sensory Functions, and Human Brain Signal Processing

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