Visuomotor integration is impaired in early stage Alzheimer's disease

Tippett, William J.; Sergio, Lauren E.

doi:10.1016/j.brainres.2006.04.049

Cited by 95 publications

(101 citation statements)

References 36 publications

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“…According to previous results, the recent findings of Tippett and Sergio 76 demonstrated that the integration of eye and hand information may be impaired in AD patients. In this experiment, it was investigated whether the accuracy of movements requiring a visuomotor transformation in neurologically healthy elderly subjects compared with patients diagnosed with probable Alzheimer's disease.…”

Section: Feedback Role In Ad Patients' Performancementioning

confidence: 72%

Alzheimer's disease and implicit memory

Machado

Cunha

Minc

et al. 2009

Arq. Neuro-Psiquiatr.

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-Specific neuropsychiatric disorders, such as Alzheimer's disease (AD) affect some forms of memory while leaving others relatively intact. In this review, we investigate particularities of the relationship between explicit and implicit memories in AD. It was found that implicit memory is preserved in AD, irrespective of the task used; in other words, there was not interference from explicit memory. In addition, it was verified that is possible through implicit memory compensatory strategies such as, activities of daily living (ADL) to compensate for the explicit memory deficits. In this sense, cognitive rehabilitation (CR) demonstrates reasonable results in the process of compensation of explicit memory deficits. Concluding, the decline in explicit memory suggests that both systems are functionally independent even if the other is compromised. We expect that when explicit memory system is not involved in competition with the implicit system, the final effect of learning is better, because all of the implicit memory capacity is engaged in learning and not in competition with the explicit system. Key WoRDS: activities of daily living, Alzheimer's disease, cognitive rehabilitation, implicit memory. Doença de Alzheimer e memória implícitaResumo -Distúrbios neuropsiquiátricos específicos, tais como a doença de Alzheimer (DA), podem afetar algumas formas de memória enquanto deixam outros relativamente intactos. Nesta revisão, nós investigamos particularidades da relação entre as memórias explicita e implícita na DA. Foi verificado que a memória é preservada na DA, independente da tarefa usada; ou seja, não ocorre interferência da memória explícita. Além disso, foi verificado que é possível através de estratégias compensatórias de memória implícita, tais como, atividades da vida diária (AVD) compensar os déficits da memória explícita. Neste sentido, a reabilitação cognitiva (RC) demonstra resultados razoáveis no processo de compensação dos déficits da memória explicita. Concluindo, a queda na memória explícita sugere que ambos os sistemas são funcionalmente independentes mesmo que outro esteja comprometido. esperamos que quando o sistema de memória explícita não está envolvido em competição com o sistema implícito, o efeito final de aprendizagem é melhor, porque toda a capacidade da memória implícita está engajada na aprendizagem e não na competição com o sistema explícito. PALAVRAS-ChAVe: atividades da vida diária, doença de Alzheimer, memória implícita, reabilitação cognitiva.

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Section: Feedback Role In Ad Patients' Performancementioning

confidence: 72%

Alzheimer's disease and implicit memory

Machado

Cunha

Minc

et al. 2009

Arq. Neuro-Psiquiatr.

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“…The ROI procedure was used to examine critical areas for visuospatial0 visuomotor production, that is, the parietal areas, which as previously noted, are essential for conducting these transformations (Boxer et Rodriguez et al, 2005;Tippett & Sergio, 2006). In addition, temporal (as noted above) and frontal regions were also evaluated to control for performance reductions which may be a result of overall dementia-related degeneration.…”

Section: Imaging Correlates Of Visuospatial Tasksmentioning

confidence: 99%

“…Historically, parietal deficits have been linked to disruptions in visuomotor planning and movement (Andersen & Buneo, 2003;Snyder et al, 1997), such as updating the spatial location of targets (Buneo & Andersen, 2006;Snyder et al, 1997) and programming coordinated arm and eye movements (Duhamel et al, 1992;Grea et al, 2002;Oyachi & Ohtsuka, 1995). Visuospatial and visuomotor ability are typically under-used in cognitive batteries for AD but have the potential to assist in diagnosing and monitoring of AD (Ghilardi et al, 1999;Tippett & Sergio, 2006). The parietal region is an area known to be vulnerable to AD pathology as it progresses from the limbic to the neocortical stage (Braak & Braak, 1991) and dysfunction in this region correlates with several visuomotor difficulties (Andersen & Buneo, 2003;Braak & Braak, 1991;Buneo et al, 2002;Nagahama et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Positron Emission Tomography (PET) and Single Positron Emission Computed Tomography (SPECT) are functional imaging techniques that can produce three dimensional maps of resting state brain activity based on glucose metabolism or blood flow, which can be helpful in inferring the presence of AD pathology (Alexander et al, 2002;Buchert et al, 2005;Cutler, 1988;Ishii et al, 2006;McGeer et al, 1986;Silverman et al, 2001;Silverman, 2004;von Broczyskowski et al, 2006) Psychophysical research has demonstrated that reductions in visuomotor ability attributed to parietal dysfunction may be useful in detecting not only the presence of AD, but also in tracking its progression (Elble & Leffler, 2000;Ghilardi et al, 1999;Kluger et al, 1997;Ott et al, 1995;Tippett & Sergio, 2006). Decline in perfusion rates within regions such as the parietal lobe, can occur in the early stages of AD.…”

Section: Introductionmentioning

confidence: 99%

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Regional cerebral blood flow correlates of visuospatial tasks in Alzheimer's disease

Tippett

Black

2008

J Int Neuropsychol Soc

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This study investigated the role of visuospatial tasks in identifying cognitive decline in patients with Alzheimer's disease (AD), by correlating neuropsychological performance with cerebral perfusion measures. There were 157 participants: 29 neurologically healthy controls (age: 70.3 6 6.6, MMSE Ն 27), 86 patients with mild AD (age: 69.18 6 8.28, MMSE Ն 21) and 42 patients moderate0severe AD (age: 68.86 6 10.69, MMSE 8-20). Single Photon Emission Computerized Tomography (SPECT) was used to derive regional perfusion ratios, and correlated using partial least squares (PLS) with neuropsychological test scores from the Benton Line Orientation (BLO) and the Rey-Osterrieth Complex Figure (RO). Cross-sectional analysis demonstrated that mean scores differed in accordance with disease status: control group (BLO 25.5, RO 33.3); mild AD (BLO 20.1, RO 25.5); moderate0severe AD (BLO 10.7, RO 16). Correlations were observed between BLO0RO and right parietal SPECT regions in the AD groups. Visuospatial performance, often undersampled in cognitive batteries for AD, is clearly impaired even in mild AD and correlates with functional deficits as indexed by cerebral perfusion ratios on SPECT implicating right hemisphere circuits. Furthermore, PLS reveals that usual spatial tasks probe a distributed brain network in both hemispheres including many areas targeted by early AD pathology. (JINS, 2008(JINS, , 14, 1034(JINS, -1045

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“…Although memory deficits are a salient feature of AD, other symptoms appear from the early stages and a representative symptom is visuomotor deficit [1] . Before the onset of clinical symptoms, the bilateral parietal lobes are affected with ADrelated pathology [2] , and show hypoperfusion as a characteristic single-photon emission computed tomography finding [3] .…”

Section: Introductionmentioning

confidence: 99%

Yamaguchi Fox-Pigeon Imitation Test: A Rapid Test for Dementia

Yamaguchi

Maki

Yamagami

2010

Dement Geriatr Cogn Disord

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Background/Aims: We herein propose a hand-gesture imitation test, consisting of a simple one-handed sign of a ‘fox’ and a complex two-handed sign of a ‘pigeon’, as a rapid, game-like test for detecting dementia/Alzheimer disease (AD) with low psychological burden. The test measures the visuomotor function, which deteriorates in the early stages of AD. Methods: We examined 88 demented subjects, 19 with mild cognitive impairment (MCI), and 53 normal controls aged 65 years or over. The subjects were classified according to the Clinical Dementia Rating (CDR). Results: The specificity of the test was 94%, and the sensitivity was 58% in CDR 0.5 (MCI), 77% in CDR 1 (mild dementia), 75% in CDR 2 (moderate dementia), and 90% in CDR 3 (severe dementia). The test could be conducted within 1 min and no subjects refused to be tested. Conclusion: This brief hand-gesture imitation test can sensitively evaluate visuomotor deficits in dementia/AD, while some subjects are unaware of their failure or even that their cognitive function is being tested. We herein describe the precise protocol for worldwide use.

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Visuomotor integration is impaired in early stage Alzheimer's disease

Cited by 95 publications

References 36 publications

Alzheimer's disease and implicit memory

Alzheimer's disease and implicit memory

Regional cerebral blood flow correlates of visuospatial tasks in Alzheimer's disease

Yamaguchi Fox-Pigeon Imitation Test: A Rapid Test for Dementia

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