Visuospatial deficits in posterior cortical atrophy: structural and functional correlates

Andrade, Katia; Kas, Aurélie; Valabrègue, Romain; Samri, Dalila; Sarazin, Marie; Habert, Marie‐Odile; Dubois, Bruno; Bartolomeo, Paolo

doi:10.1136/jnnp-2012-302278

Cited by 26 publications

(21 citation statements)

References 24 publications

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“…Selective deficits in dorsal pathways have previously been demonstrated using volume measurements [8], PET [47] and SPECT [48]. Since the BOLD fMRI signal is known to be influenced by cortical atrophy, metabolism and blood flow, our data support and add to the existing literature.…”

Section: Discussionsupporting

confidence: 86%

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Functional neural substrates of posterior cortical atrophy patients

2015

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Posterior cortical atrophy (PCA) is a neurodegenerative syndrome in which the most pronounced pathologic involvement is in the occipito-parietal visual regions. Herein, we aimed to better define the cortical reflection of this unique syndrome using a thorough battery of behavioral and functional MRI (fMRI) tests. Eight PCA patients underwent extensive testing to map their visual deficits. Assessments included visual functions associated with lower and higher components of the cortical hierarchy, as well as dorsal- and ventral-related cortical functions. fMRI was performed on five patients to examine the neuronal substrate of their visual functions. The PCA patient cohort exhibited stereopsis, saccadic eye movements and higher dorsal stream-related functional impairments, including simultant perception, image orientation, figure-from-ground segregation, closure and spatial orientation. In accordance with the behavioral findings, fMRI revealed intact activation in the ventral visual regions of face and object perception while more dorsal aspects of perception, including motion and gestalt perception, revealed impaired patterns of activity. In most of the patients, there was a lack of activity in the word form area, which is known to be linked to reading disorders. Finally, there was evidence of reduced cortical representation of the peripheral visual field, corresponding to the behaviorally assessed peripheral visual deficit. The findings are discussed in the context of networks extending from parietal regions, which mediate navigationally related processing, visually guided actions, eye movement control and working memory, suggesting that damage to these networks might explain the wide range of deficits in PCA patients.

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Section: Discussionsupporting

confidence: 86%

“…Since the BOLD fMRI signal is known to be influenced by cortical atrophy, metabolism and blood flow, our data support and add to the existing literature. One example of the association between cortical atrophy and regional cerebral blood flow in PCA was previously described [48].…”

Section: Discussionmentioning

confidence: 99%

Functional neural substrates of posterior cortical atrophy patients

2015

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“…It is associated with prominent parieto-occipital atrophy with relative sparing of the medial temporal lobe. Thus, this variant of AD directly affects the key anatomical structures that are part of Posner's orienting network and PCA presents with profound visuospatial deficits [39]. Patients often manifest the features of Balint's syndrome (simultanagnosia, oculomotor apraxia and optic ataxia) [38].…”

Section: Orienting and Spatial Attentionmentioning

confidence: 99%

Impairments of attention in Alzheimer’s disease

Malhotra

2019

Current Opinion in Psychology

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Highlights -Multiple aspects of attention are affected in Alzheimer's Disease (AD) -The Locus Coeruleus is one of the first brain regions to be affected by tau pathology in AD -Deficits in Arousal, Orienting and Executive Control of attention can occur in the early stages of the disease -Alzheimer's Disease has a more heterogeneous cognitive profile that previously thought -Combination therapy may be more successful than symptomatic treatments aimed at a single neurotransmitter system

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“…Posterior cortical atrophy is a disorder of higher visual function that causes significant visual dysfunction in the absence of ocular disease, as well as constructional apraxia, visual field deficits, and environmental disorientation. 11,12 This disorder is primarily thought to be associated with changes in posterior brain regions, including the parietal and occipital lobes. Logopenic aphasia is a type of primary progressive aphasia (PPA) associated with AD (i.e., amyloid) rather than frontotemporal dementia-(FTD-) like pathology and features impaired word retrieval and sentence repetition in the absence of motor speech or grammatical abnormalities.…”

Section: Degenerative Diseases and Dementiasmentioning

confidence: 99%

Neuroimaging Biomarkers of Neurodegenerative Diseases and Dementia

2013

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Neurodegenerative disorders leading to dementia are common diseases that affect many older and some young adults. Neuroimaging methods are important tools for assessing and monitoring pathological brain changes associated with progressive neurodegenerative conditions. In this review, the authors describe key findings from neuroimaging studies (magnetic resonance imaging and radionucleotide imaging) in neurodegenerative disorders, including Alzheimer’s disease (AD) and prodromal stages, familial and atypical AD syndromes, frontotemporal dementia, amyotrophic lateral sclerosis with and without dementia, Parkinson’s disease with and without dementia, dementia with Lewy bodies, Huntington’s disease, multiple sclerosis, HIV-associated neurocognitive disorder, and prion protein associated diseases (i.e., Creutzfeldt-Jakob disease). The authors focus on neuroimaging findings of in vivo pathology in these disorders, as well as the potential for neuroimaging to provide useful information for differential diagnosis of neurodegenerative disorders.

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Visuospatial deficits in posterior cortical atrophy: structural and functional correlates

Abstract: The results indicate that rightward bias (sign of left-sided neglect) in PCA depends on dysfunction of a large fronto-parietal network in the right hemisphere, related to both cortical atrophy and decreased cerebral perfusion.

Cited by 26 publications

References 24 publications

Functional neural substrates of posterior cortical atrophy patients

Functional neural substrates of posterior cortical atrophy patients

Impairments of attention in Alzheimer’s disease

Neuroimaging Biomarkers of Neurodegenerative Diseases and Dementia

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