Visuospatial impairment in dementia with Lewy bodies and Alzheimer's disease: a process analysis approach

Simard, Martine; Reekum, Robert van; Myran, David

doi:10.1002/gps.839

Cited by 50 publications

(38 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…61,64,66,73,77,81 Of note, results showing overall equivalent visuospatial performance between groups have indicated greater DLB-associated executive errors (eg, planning/organization) on qualitative analysis. 67,71 Such findings are consistent with the relative paucity of LBs in parietal and especially occipital cortex, but a catastrophic loss of cholinergic and dopaminergic pathways to these regions because of a massive preponderance of LB pathology in downstream brainstem regions. 50…”

Section: Dlbsupporting

confidence: 80%

Cognitive-Behavioral Profiles of Neurodegenerative Dementias: Beyond Alzheimer's Disease

Lévy

Chelune

2007

J Geriatr Psychiatry Neurol

View full text Add to dashboard Cite

The neurocognitive and behavioral profiles of vascular dementia and vascular cognitive impairment, dementia with Lewy bodies and Parkinson's disease with dementia, and dementia syndromes associated with frontotemporal lobar degenerations are compared and contrasted with Alzheimer's dementia (AD). Vascular dementia/vascular cognitive impairment is characterized by better verbal memory performance, worse quantitative executive functioning, and prominent depressed mood. Dementia with Lewy bodies and Parkinson's disease with dementia are equally contrasted with AD by defective processing of visual information, better performance on executively supported verbal learning tasks, greater attentional variability, poorer qualitative executive functioning, and the presence of mood-congruent visual hallucinations. The frontal variant of frontotemporal lobar degeneration (frontotemporal dementia) differs from AD by better multimodal retention on learning tasks, different patterns of generative word fluency, defective qualitative executive functioning, and by markedly impairment of comportment. For temporal variants of frontotemporal lobar degenerations, progressive aphasia and semantic dementia, worse language performance relative to AD is typically characteristic.

show abstract

Section: Dlbsupporting

confidence: 80%

Cognitive-Behavioral Profiles of Neurodegenerative Dementias: Beyond Alzheimer's Disease

Lévy

Chelune

2007

J Geriatr Psychiatry Neurol

View full text Add to dashboard Cite

show abstract

“…Numerous studies have observed greater impairments in DLB compared to AD on visuospatial and constructional tasks (Collerton et al 2003;Hansen et al 1990;Noe et al 2004;Simard et al 2003). Even brief screening tasks, such as pentagon-copying from the Mini Mental Status Examination (MMSE; Folstein et al 2001) have been reported to reveal greater impairment in DLB (Ala et al 2001) or DLB and PDD (Cormack et al 2004a) compared to AD.…”

Section: Visuoperceptual and Spatial Functionsmentioning

confidence: 96%

“…Both DLB and PDD show relatively preserved memory performance compared to AD subjects on the Dementia Rating Scale (Aarsland et al 2003b). Patients with AD generally also perform more poorly than DLB on the immediate and delayed recall portions of tests of word list learning such as the Selective Reminding Test (SRT; Noe et al 2004) and the California Verbal Learning Test (CVLT; Simard et al 2002), though one study found DLB to perform better than AD only on the recognition part of the CVLT (Hamilton et al 2004), perhaps because some of the DLB subjects in that study may actually have had the Lewy body variant of AD. As on list learning, DLB subjects may show better prose passage (WMS-R Logical Memory) immediate and delayed recall than AD (Calderon et al 2001).…”

Section: Memorymentioning

confidence: 98%

Neuropsychological Characteristics of Dementia with Lewy Bodies and Parkinson’s Disease with Dementia: Differentiation, Early Detection, and Implications for “Mild Cognitive Impairment” and Biomarkers

2008

View full text Add to dashboard Cite

Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) are neurodegenerative conditions sharing a disorder of alpha-synuclein metabolism. Temporal differences in the emergence of symptoms and clinical features warrant the continued clinical distinction between DLB and PDD. While DLB and PDD groups' neuropsychological profiles often differ from those in Alzheimer's disease (AD), the diagnostic sensitivity, specificity, and predictive values of these profiles remain largely unknown. PDD and DLB neuropsychological profiles share sufficient similarity to resist accurate and reliable differentiation. Although heterogeneous cognitive changes (predominantly in memory and executive function) may manifest earlier and more frequently than previously appreciated in Parkinson's disease (PD), and executive deficits may be harbingers of dementia, the enthusiasm to uncritically extend the concept of mild cognitive impairment (MCI) to PD should be tempered. Instead, future research might strive to identify the precise neuropsychological characteristics of the prodromal stages of PD, PDD, and DLB which, in conjunction with other potential biomarkers, facilitate early and accurate diagnosis, and the definition of neuroprotective, neurorestorative, and symptomatic treatment endpoints.

show abstract

“…40 Barnes and David 41 compared visual imagery, visual perception, and recognition memory in nondemented PD patients with and without hallucinations and found that PD patients with visual hallucinations were more impaired in object perception. In the present study, hallucinating DLB/ PDD patients were more impaired in all visual scores compared to patients without hallucinations.…”

Section: Figure (A Through C) Mean and 95% CI Of The Discrimination mentioning

confidence: 99%

Visual perception in Parkinson disease dementia and dementia with Lewy bodies

Mosimann

Mather²,

Wesnes³

et al. 2004

Neurology

260

176

View full text Add to dashboard Cite

Abstract-Objective:To quantify visual discrimination, space-motion, and object-form perception in patients with Parkinson disease dementia (PDD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD). Methods: The authors used a cross-sectional study to compare three demented groups matched for overall dementia severity (PDD: n ϭ 24; DLB: n ϭ 20; AD: n ϭ 23) and two age-, sex-, and education-matched control groups (PD: n ϭ 24, normal controls [NC]: n ϭ 25). Results: Visual perception was globally more impaired in PDD than in nondemented controls (NC, PD), but was not different from DLB. Compared to AD, PDD patients tended to perform worse in all perceptual scores. Visual perception of patients with PDD/DLB and visual hallucinations was significantly worse than in patients without hallucinations. Conclusions: Parkinson disease dementia (PDD) is associated with profound visuoperceptual impairments similar to dementia with Lewy bodies (DLB) but different from Alzheimer disease. These findings are consistent with previous neuroimaging studies reporting hypoactivity in cortical areas involved in visual processing in PDD and DLB. NEUROLOGY 2004;63:2091-2096 Parkinson disease (PD) is associated with a higher risk of developing dementia compared to healthy elderly controls; longitudinal studies suggest that up to 78% of PD patients will develop dementia after nearly two decades of motor symptoms.1 Once dementia is established, clinical symptoms of PD dementia (PDD) may show, apart from a longer duration of motor features, considerable overlap with dementia with Lewy bodies (DLB). The postural instability-gait type of parkinsonism is overrepresented in PDD and DLB 2 and both disorders show similar fluctuation of attention 3 and response to cholinergic therapy. 4,5 Studies comparing visual perception and visual construction of PDD with Alzheimer disease (AD) have revealed contradictory results. Some studies report PDD to be more impaired, 6,7 whereas other studies found no differences. 8,9 Similar inconsistencies have been found when perception of PD patients was compared with healthy controls.10 Since operationalized criteria to define the clinical boundaries between PD and PDD or PDD and DLB require refinement, these inconsistencies may be partly due to diagnostic heterogeneity. When DLB was compared with AD, studies consistently reported greater visual impairment in DLB 11 and a recent study found similar impairments in pentagon copying in DLB and PDD.12 Some of these studies used construction tasks as evidence, but this may not be legitimate given the motor impairments in these patients. Studies quantifying visual perception of DLB and PDD using tasks without motor requirements are lacking.Peripheral structures such as the retina, the optic nerve and tract, and primary visual cortex are multimodal in their function, whereas the visual association cortex is more specialized.13 Low-level visual discrimination is mainly processed in visual area V1/ V2, whereas high-level visual functions require additional activati...

show abstract

Visuospatial impairment in dementia with Lewy bodies and Alzheimer's disease: a process analysis approach

Abstract: Subjects with DLB and psychosis have more severe visual-perception (VH errors) impairments than subjects with DLB and predominant parkinsonian features, and AD subjects.

Cited by 50 publications

References 20 publications

Cognitive-Behavioral Profiles of Neurodegenerative Dementias: Beyond Alzheimer's Disease

Cognitive-Behavioral Profiles of Neurodegenerative Dementias: Beyond Alzheimer's Disease

Neuropsychological Characteristics of Dementia with Lewy Bodies and Parkinson’s Disease with Dementia: Differentiation, Early Detection, and Implications for “Mild Cognitive Impairment” and Biomarkers

Visual perception in Parkinson disease dementia and dementia with Lewy bodies

Contact Info

Product

Resources

About