Visuospatial impairment in Parkinson's disease: The role of laterality

Karádi, Kázmér; Lucza, Tivadar; Aschermann, Zsuzsanna; Komoly, Sámuel; Deli, Gabriella; Bosnyák, Edit; Ács, Pongrác; Horváth, Réka; Janszky, József; Kovács, Norbert

doi:10.1080/1357650x.2014.936444

Cited by 32 publications

(23 citation statements)

References 45 publications

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“…39,40 These studies, however, are based on clinical scales and questioners, and this might limit the generalizability of their results. The most consistent performancebased evidence suggest that RPD patients tend to have a specific impairment in some language domains, 36 whereas LPD patients show visuospatial impairments 41,42 and impaired vocal emotion processing. 43,44 All of these functions have clear lateralization in healthy subjects, suggesting that lateralized PD patients represent a good model to assess whether inhibitory control relies on a right-lateralized network.…”

Section: Inhibitory Control Is Not Right Lateralized In Pd Patientsmentioning

confidence: 99%

Early‐Stage Parkinson's Patients Show Selective Impairment in Reactive But Not Proactive Inhibition

et al. 2019

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Background It is well known that a deficit in inhibitory control is a hallmark of Parkinson's disease (PD). However, inhibition is not a unitary construct, and it is unclear whether patients in the early stage of the disease (Hoehn and Yahr stage 1) exhibit a deficit in outright stopping (reactive inhibition), a deficit in the ability to shape their response strategies according to the context (proactive inhibition), or both. Objective We assessed whether PD patients at Hoehn and Yahr stage 1 show a global or selective impairment in inhibitory control. As it has been suggested that inhibition relies upon a right‐lateralized pathway, we tested whether left‐dominant PD patients suffered from a more severe deficit in this executive function than right‐dominant PD patients. Methods Via a reaching stop‐signal task, we assessed both proactive and reactive inhibition in 17 left‐dominant PD and 17 right‐dominant PD patients and in 24 age‐matched participants. Results We found that reactive inhibition was more impaired in PD patients than in healthy participants. However, proactive inhibition was not affected. Furthermore, we found no differences between left‐dominant PD and right‐dominant PD patients. Conclusions For the first time, we found evidence for a deficit of reactive inhibition in the early‐stage PD patients in the absence of evidence for deficits in proactive inhibition. These findings have clinical relevance as they provide critical insights on the time course of the disease. In addition, we confirmed, on a population of PD patients at Hoehn and Yahr stage 1, previous results showing that the onset of the disease does not affect inhibition. © 2019 International Parkinson and Movement Disorder Society

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Section: Inhibitory Control Is Not Right Lateralized In Pd Patientsmentioning

confidence: 99%

Early‐Stage Parkinson's Patients Show Selective Impairment in Reactive But Not Proactive Inhibition

et al. 2019

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“…The ROCF is a common neuropsychological screening method for visuospatial abilities [33, 34]. Particularly, the copy variant of the task measures visuospatial construction while the delayed variant indicates visuospatial memory performance [34].…”

Section: Methodsmentioning

confidence: 99%

Correlation of Visuospatial Ability and EEG Slowing in Patients with Parkinson’s Disease

Eichelberger

Calabrese

Meyer

et al. 2017

Parkinson's Disease

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Background. Visuospatial dysfunction is among the first cognitive symptoms in Parkinson's disease (PD) and is often predictive for PD-dementia. Furthermore, cognitive status in PD-patients correlates with quantitative EEG. This cross-sectional study aimed to investigate the correlation between EEG slowing and visuospatial ability in nondemented PD-patients. Methods. Fifty-seven nondemented PD-patients (17 females/40 males) were evaluated with a comprehensive neuropsychological test battery and a high-resolution 256-channel EEG was recorded. A median split was performed for each cognitive test dividing the patients sample into either a normal or lower performance group. The electrodes were split into five areas: frontal, central, temporal, parietal, and occipital. A linear mixed effects model (LME) was used for correlational analyses and to control for confounding factors. Results. Subsequently, for the lower performance, LME analysis showed a significant positive correlation between ROCF score and parietal alpha/theta ratio (b = .59, p = .012) and occipital alpha/theta ratio (b = 0.50, p = .030). No correlations were found in the group of patients with normal visuospatial abilities. Conclusion. We conclude that a reduction of the parietal alpha/theta ratio is related to visuospatial impairments in PD-patients. These findings indicate that visuospatial impairment in PD-patients could be influenced by parietal dysfunction.

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“…Diszexekutív zavar Parkinson-kór-ban gyakran már a betegség korai stádiumában jelentkezhet, és a kogníció olyan területeit is károsíthatja, mint a komplex fi gyelem, a munkamemória, a viselkedésterve-zés, a feladatváltás folyamata [7]. Szintén gyakran talál-kozhatunk a verbális fl uenciát, illetve a vizuális és téri memóriát érintő eltérésekkel, amelyek megjelenése és súlyossága összefügg a Parkinson-kór aszimmetriájával [8].…”

Section: Parkinson-kórban éSzlelhető Neurokognitív Eltérésekunclassified

Neurokognitív zavarok diagnosztizálási és kezelési lehetőségei Parkinson-kórban

et al. 2015

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A jelen tudományos közleményt a szerzők a Pécsi Tudományegyetem alapításának 650. évfordulójának szentelik.Az összefoglaló közleményben a szerzők részletesen bemutatják a Parkinson-kórhoz társuló neurokognitív zavarok jellegzetességeit, felmérésük lehetséges módjait és kezelési lehetőségeit. A neurokognitív zavarok meghatározását sokáig nehezítette a diagnosztikai kritériumrendszerek sokszínűsége. Az Amerikai Pszichiátriai Társaság által a Mentális Rendellenességek Kórmeghatározó és Statisztikai Kézikönyvének ötödik átdolgozása (Diagnostic and Statistical Manual of Mental Disorders, DSM-5) magával hozta a major és az enyhe neurokognitív zavar megnevezéseket a demencia és az enyhe kognitív zavar fogalmát helyettesítendően. A DSM-5 neurokognitív zavarra vonatkozó defi ní-ciói a klinikumban jól alkalmazhatóak, ám szükségessé vált a leggyakrabban használt szűrőtesztek, úgymint a Mini

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Visuospatial impairment in Parkinson's disease: The role of laterality

Cited by 32 publications

References 45 publications

Early‐Stage Parkinson's Patients Show Selective Impairment in Reactive But Not Proactive Inhibition

Early‐Stage Parkinson's Patients Show Selective Impairment in Reactive But Not Proactive Inhibition

Correlation of Visuospatial Ability and EEG Slowing in Patients with Parkinson’s Disease

Neurokognitív zavarok diagnosztizálási és kezelési lehetőségei Parkinson-kórban

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