Visuospatial processing impairment following mild COVID-19

Paula, Jonas Jardim de; Paiva, Rachel Elisa Rodrigues Pereira de; Costa, Danielle de Souza; Silva, Nathalia Gualberto Souza e; Rosa, Daniela V.; Januário, José Nélio; Silva, Luciana Costa; Miranda, Débora Marques de; Romano-Silva, Marco Aurélio

doi:10.1101/2021.02.18.21251442

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…Individuals who recovered from suspected or confirmed COVID-19 had a worse performance on cognitive tests in multiple domains when matched with non-COVID-19 subjects, showing evident deficits even amongst those without severe disease [18]. In a preliminary study, we demonstrated important deficits in the visuospatial processing in around 25% of mild (not requiring hospitalization) COVID-19 patients [19]. Here, we report results of the baseline of a prospective observational cohort study of individuals with mild COVID-19 cases.…”

Section: Introductionmentioning

confidence: 68%

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

et al. 2022

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People recovered from COVID-19 may still present complications including respiratory and neurological sequelae. In other viral infections, cognitive impairment occurs due to brain damage or dysfunction caused by vascular lesions and inflammatory processes. Persistent cognitive impairment compromises daily activities and psychosocial adaptation. Some level of neurological and psychiatric consequences were expected and described in severe cases of COVID-19. However, it is debatable whether neuropsychiatric complications are related to COVID-19 or to unfoldings from a severe infection. Nevertheless, the majority of cases recorded worldwide were mild to moderate self-limited illness in non-hospitalized people. Thus, it is important to understand what are the implications of mild COVID-19, which is the largest and understudied pool of COVID-19 cases. We aimed to investigate adults at least four months after recovering from mild COVID-19, which were assessed by neuropsychological, ocular and neurological tests, immune markers assay, and by structural MRI and 18 FDG-PET neuroimaging to shed light on putative brain changes and clinical correlations. In approximately one-quarter of mild-COVID-19 individuals, we detected a specific visuoconstructive deficit, which was associated with changes in molecular and structural brain imaging, and correlated with upregulation of peripheral immune markers. Our findings provide evidence of neuroinflammatory burden causing cognitive deficit, in an already large and growing fraction of the world population. While living with a multitude of mild COVID-19 cases, action is required for a more comprehensive assessment and follow-up of the cognitive impairment, allowing to better understand symptom persistence and the necessity of rehabilitation of the affected individuals.

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Section: Introductionmentioning

confidence: 68%

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

et al. 2022

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“…COVID-19 is a mild to moderate and self-limited illness in most cases and it is caused by severe acute respiratory syndrome coronavirus-2 (SARS-COV-2), a novel coronavirus (1,2). Currently, more than 755 million confirmed cases are reported by WHO worldwide (3).…”

Section: Introductionmentioning

confidence: 99%

Neuroimaging findings of COVID-19: a systematic review on longitudinal studies

Nabizadeh,

Fallahi,

Zafari

et al. 2024

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Background: There is high number of evidence regarding the involvement of the central nervous system (CNS) in patients with severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). The aim of our systematic review study is to evaluate the current state of knowledge regarding neuroimaging findings after COVID-19 by focusing on longitudinal studies. By limiting our review to this type of study design, we aimed to provide a more comprehensive and detailed picture of the long-term effects of COVID-19 on the brain. Methods: Three electronic databases (PubMed, Scopus, and Web of Science) were searched for relevant studies. We included studies that investigated longitudinal brain changes in patients with COVID-19 with available neuroimaging findings at least two different times. Results: After a two-step review, 10 studies were included in our qualitative synthesis. Brain MRI was the only imaging modality in seven studies, whereas one used only FDG-PET, one used CT/MRI, and one used CT/MRI/FDG-PET. Our results demonstrated consistent evidence of lesions, white matter microstructural, grey matter, metabolism, and blood flow alterations in comparison with healthy controls. Conclusion: Our systematic review provides evidence of widespread microstructural, grey matter, metabolism, and blood flow alterations in patients afflicted with COVID-19. The longitudinal nature of the included studies highlights the importance of ongoing monitoring and follow-up imaging in patients after COVID-19 infection.

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“…[24] investigated individuals who recovered from suspected or confirmed COVID-19 and showed these patients had a worse performance on cognitive tests in multiple domains when matched with non-COVID-19 subjects, showing evident deficits even amongst those without severe disease [24]. In a preliminary study, we demonstrated important deficits in the visuospatial processing in around 25% of mild (not requiring hospitalization) COVID-19 patients [25]. Here, we report results of a prospective observational cohort study of individuals with mild COVID-19 cases.…”

Section: Introductionmentioning

confidence: 99%

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

Paula

Paiva

Silva

et al. 2022

Preprint

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People recovered from COVID-19 may still present complications including respiratory and neurological sequelae. In other viral infections, cognitive impairment occurs due to brain damage or dysfunction caused by vascular lesions and inflammatory processes. Persistent cognitive impairment compromises daily activities and psychosocial adaptation. Some level of neurological and psychiatric consequences were expected and described in severe cases of COVID-19. However, it is debatable whether neuropsychiatric complications are related to COVID-19 or to unfoldings from a severe infection. Nevertheless, the majority of cases recorded worldwide were mild to moderate self-limited illness in non-hospitalized people. Thus, it is important to understand what are the implications of mild COVID-19, which is the largest and understudied pool of COVID-19 cases. We aimed to investigate adults at least four months after recovering from mild COVID-19, which were assessed by neuropsychological, ocular and neurological tests, immune markers assay, and by structural MRI and 18FDG-PET neuroimaging to shed light on putative brain changes and clinical correlations. In approximately one-quarter of mild-COVID-19 individuals, we detected a specific visuoconstructive deficit, which was associated with changes in molecular and structural brain imaging, and correlated with upregulation of peripheral immune markers. Our findings provide evidence of neuroinflammatory burden causing cognitive deficit, in an already large and growing fraction of the world population. While living with a multitude of mild COVID-19 cases, action is required for a more comprehensive assessment and follow-up of the cognitive impairment, allowing to better understand symptom persistence and the necessity of rehabilitation of the affected individuals.

show abstract

Visuospatial processing impairment following mild COVID-19

Cited by 3 publications

References 4 publications

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

Neuroimaging findings of COVID-19: a systematic review on longitudinal studies

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

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