Visuospatial Working Memory in School-aged Children Exposed<i>In Utero</i>to Cocaine

Mayes, Linda C.; Snyder, Peter J.; Langlois, Eric; Hunter, Nicole

doi:10.1080/09297040600888753

Cited by 48 publications

(43 citation statements)

References 48 publications

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“…We found a significant association between PCE and short-term memory (Richardson et al, 2009), and other researchers have reported deficits in specific areas such as verbal reasoning/memory (Bennett et al, 2002), executive function , cognitive processing/learning (Bridgett et al, 2011;Mayes et al, 2005Mayes et al, , 2007, visual spatial/math skills (Singer et al, , 2008, visual motor integration Schroder et al, 2004), and attention, inhibitory control, and impulsivity (Accornero et al, 2007;Bandstra et al, 2001;Bendersky et al, 2003;Carmody et al, 2011;Noland et al, 2005;Rose-Jacobs et al, 2009). However, there are also reports that show no negative effects of PCE on specific areas of cognition (Betancourt et al, 2011;Eyler et al, 2009;Hurt et al, 2009;Li et al, 2009;, and most groups, including ours, do not find a relation between PCE and global cognitive development (Accornero et al, 2007;Bandstra et al, 2002;Frank et al, 2005;Hurt et al, 1997Hurt et al, , 2001Messinger et al, 2004;Morrow et al, 2004Morrow et al, , 2006Singer et al, 2004).…”

Section: Introductionmentioning

confidence: 75%

Effects of prenatal cocaine exposure on adolescent development

Richardson

Goldschmidt

Day

2009

Neurotoxicology and Teratology

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The associations between prenatal cocaine exposure (PCE) and adolescent behavior, cognitive development, and physical growth were examined in 219 15-year-olds who have participated in a longitudinal study since their fourth gestational month. During the first trimester, 42% of the women used cocaine, with use declining across pregnancy. At the 15-year follow-up, the caregivers were, on average, 43 years old, had 13 years of education, and 50% were African American. First trimester PCE was not associated with global cognitive development or with measures of learning and memory. First trimester PCE was significantly related to adolescentreported delinquent behavior, poorer problem solving and abstract reasoning, and reduced weight, height, and head circumference at 15 years. These results were significant after other factors that affect these domains were controlled in regression analyses. In addition, exposure to violence partially mediated the effect of PCE on delinquent behavior. These adolescent domains are important because they are predictors of poorer adult functioning.

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Section: Introductionmentioning

confidence: 75%

Effects of prenatal cocaine exposure on adolescent development

Richardson

Goldschmidt

Day

2009

Neurotoxicology and Teratology

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“…However, these structures are involved in multiple processes (and the reduced responses observed were not constrained to only these regions); thus the larger developmental implications of these findings remains to be determined. For example, given the role of the striatum in habit formation and learning, these findings might relate to the working memory deficits (Mayes et al, 2007) reported among children with PCE. Similarly, reductions in PFC activations may relate to previously reported impairments in response inhibition (Accornero et al, 2007), which could influence multiple developmental processes (such as the appropriate inhibition of negative or anxiety-provoking thoughts or actions) other than substance-use initiation.…”

Section: Developmental Implicationsmentioning

confidence: 99%

“…Prenatal cocaine exposure (PCE) is associated with negative behaviors during early childhood, including externalizing and behavioral problems (Ackerman et al, 2010) and poor sustained attention (Ackerman et al, 2010), inhibitory control (Bridgett and Mayes, 2011) and working memory (Mayes et al, 2007). By contrast, effects of PCE during adolescence and young adulthood may be more subtle than those observed during early childhood and are less well understood (Buckingham-Howes et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Prenatal Cocaine Exposure and Adolescent Neural Responses to Appetitive and Stressful Stimuli

Yip

Potenza

Balodis

et al. 2014

Neuropsychopharmacol

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Preclinical research has demonstrated the effects of prenatal cocaine exposure (PCE) on brain regions involved in emotional regulation, motivational control, and addiction vulnerability-eg, the ventral striatum (VS), anterior cingulate (ACC), and prefrontal cortex (PFC). However, little is known about the function of these regions in human adolescents with PCE. Twenty-two adolescents with PCE and 22 age-, gender-, and IQ-matched non-cocaine exposed (NCE) adolescents underwent functional magnetic resonance imaging (fMRI) during exposure to individually personalized neutral/relaxing, stressful, and favorite-food cues. fMRI data were compared using grouplevel two-tailed t-tests in the BioImage Suite. In comparison with NCE adolescents, PCE adolescents had reduced activity within cortical and subcortical brain regions, including the VS, ACC, and medial and dorslolateral PFC during exposure to favorite-food cues but did not differ in neural responses to stress cues. Subjective food craving was inversely related to dorsolateral PFC activation among PCE adolescents. Among PCE adolescents, subjective anxiety ratings correlated inversely with activations in the orbitofrontal cortex and brainstem during the stress condition and with ACC, dorsolateral PFC, and hippocampus activity during the neutral-relaxing condition. Thus adolescents with PCE display hypoactivation of brain regions involved in appetitive processing, with subjective intensities of craving and anxiety correlating inversely with extent of activation. These findings suggest possible mechanisms by which PCE might predispose to the development of addictions and related disorders, eg, substance-use disorders and binge-eating.

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“…190,[242][243][244][245][246][247][248][249][250] However, several studies have revealed alterations in various aspects of executive functioning, 221,241 including visual-motor ability, 244 attention, [251][252][253] and working memory. 254 To date, limited data are available revealing an association between prenatal methamphetamine exposure and IQ. 255 …”

Section: Behaviormentioning

confidence: 99%

Prenatal Substance Abuse: Short- and Long-term Effects on the Exposed Fetus

Behnke¹,

Levy²,

Ammerman³

et al. 2013

Pediatrics

497

389

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Prenatal substance abuse continues to be a significant problem in this country and poses important health risks for the developing fetus. The primary care pediatrician’s role in addressing prenatal substance exposure includes prevention, identification of exposure, recognition of medical issues for the exposed newborn infant, protection of the infant, and follow-up of the exposed infant. This report will provide information for the most common drugs involved in prenatal exposure: nicotine, alcohol, marijuana, opiates, cocaine, and methamphetamine.

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Visuospatial Working Memory in School-aged Children ExposedIn Uteroto Cocaine

Abstract: Children exposed in utero to cocaine exhibit a possible impairment in procedural learning and diminished efficiency in creating and accessing an internal spatial map to master the hidden maze.

Cited by 48 publications

References 48 publications

Effects of prenatal cocaine exposure on adolescent development

Effects of prenatal cocaine exposure on adolescent development

Prenatal Cocaine Exposure and Adolescent Neural Responses to Appetitive and Stressful Stimuli

Prenatal Substance Abuse: Short- and Long-term Effects on the Exposed Fetus

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