Cyber-Physical Systems (CPS) are often composed of a great number of mobile, wireless networked devices. In order to guarantee the system performing, management policies focused on becoming transparent to high-level applications, the changes in the hardware platform have to be implemented. However, traditional reactive methodologies and basic proposed predictive solutions are not valid either due to the extremely dynamical behavior of CPS or because the high number of involved devices prevents fulfill the timing requirements. Therefore, in this paper, we present an advance predictive solution for managing the mobility and device lifecycle, being able to meet all requirements of CPS. The solution is based on an infinite loop, which calculates, in each iteration, a sequence of future system states using a CPS simulator and interpolation algorithms. Furthermore, an experimental validation is provided in order to determine the performing of the proposed solution.