Vital capacity induction with 8% sevoflurane and N 2 O causes cerebral hyperemia

Iwasaki, Kanako; Nomoto, Y; Ishiwata, Miwako; Yokota, Tetsuya; Ogawa, Ryo

doi:10.1007/s005400300001

Cited by 9 publications

(10 citation statements)

References 16 publications

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“…Iwasaki et al examined the changes in HbO 2 and HbTot that occur after induction with 67% N 2 O and propofol, sevoflurane at 5%, or sevoflurane at 8% [ 36 ]. The patient's hemodynamic changes were continuously recorded from preinduction period until three minutes after intubation.…”

Section: Resultsmentioning

confidence: 99%

“…The patient's hemodynamic changes were continuously recorded from preinduction period until three minutes after intubation. This study reported significant increases in HbO 2 and HbTot after 8% sevoflurane induction compared to 5% sevoflurane and propofol [ 36 ]. This suggests that fNIRS is sensitive to changes caused by different concentrations of the same anesthetic.…”

Section: Resultsmentioning

confidence: 99%

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Near-Infrared Spectroscopy for the Evaluation of Anesthetic Depth

Hernandez-Meza

İzzetoğlu

Osbakken

et al. 2015

BioMed Research International

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The standard-of-care guidelines published by the American Society of Anesthesiologists (ASA) recommend monitoring of pulse oximetry, blood pressure, heart rate, and end tidal CO2 during the use of anesthesia and sedation. This information can help to identify adverse events that may occur during procedures. However, these parameters are not specific to the effects of anesthetics or sedatives, and therefore they offer little, to no, real time information regarding the effects of those agents and do not give the clinician the lead-time necessary to prevent patient “awareness.” Since no “gold-standard” method is available to continuously, reliably, and effectively monitor the effects of sedatives and anesthetics, such a method is greatly needed. Investigation of the use of functional near-infrared spectroscopy (fNIRS) as a method for anesthesia or sedation monitoring and for the assessment of the effects of various anesthetic drugs on cerebral oxygenation has started to be conducted. The objective of this paper is to provide a thorough review of the currently available published scientific studies regarding the use of fNIRS in the fields of anesthesia and sedation monitoring, comment on their findings, and discuss the future work required for the translation of this technology to the clinical setting.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Near-Infrared Spectroscopy for the Evaluation of Anesthetic Depth

Hernandez-Meza

İzzetoğlu

Osbakken

et al. 2015

BioMed Research International

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show abstract

“…The different effects of iv anesthetics on oxygen saturation may be due to the different actions on cerebral blood flow and oxygen consumption; both propofol and thiopental maintain flow-metabolism coupling 12 whereas etomidate is associated with a rapid reduction in cerebral blood flow accompanied by a slower reduction in oxygen consumption. 13 Iwasaki et al 14 compared the effects of higher doses of sevoflurane (8%) on cerebral blood volume with 5% sevoflurane and propofol on cerebral volume using BIS and NIRS during induction of anesthesia. Only vital capacity inhalation with 8% sevoflurane produced an increase in cerebral blood volume, suggesting that high concentrations of sevoflurane may be dangerous in patients with elevated intracranial pressure.…”

Section: Discussionmentioning

confidence: 99%

Ľindex bispectral et la saturation en oxygène du sang cérébral régional pendant ľanesthésie au propofol/N2O

Kanemaru

Nishikawa

Goto

2006

Can J Anesth/J Can Anesth

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Purpose:A study was undertaken to compare the influence of midazolam, isoflurane, and aminophylline (which may antagonize anesthetic action) on bispectral index (BIS) and regional cerebral oxygen saturation (rSO 2 ) during propofol/N 2 O anesthesia, and to test the hypothesis that the drug-induced changes in BIS values are accompanied by a change in rSO 2 .Methods: General anesthesia was administered to 36 patients with a continuous infusion of propofol to maintain a BIS value of 40 ± 5. After baseline recordings, patients were randomly assigned to receive either midazolam, isoflurane, or aminophylline. Bispectral index values, rSO 2 using near-infrared spectroscopy, and hemodynamic parameters were recorded for 60 min.Results: Midazolam (0.05 mg·kg -1 ) significantly decreased the BIS from 47.8 ± 5.4 to 35.0 ± 4.5 at five minutes after injection (P < 0.001 vs control) during propofol anesthesia, whereas the rSO 2 was unchanged. Similarly, isoflurane (1.1% end-tidal) decreased the BIS from 42.5 ± 7.5 to 27.8 ± 6.9 (P < 0.001) without affecting rSO 2 . In contrast, aminophylline (3 mg·kg -1 ) was associated with an increase in BIS from 41.6 ± 2.1 to 48.3 ± 9.2 at five minutes after injection (P < 0.05) without affecting rSO 2 .Conclusions: Midazolam or isoflurane-induced decreases in the BIS during propofol anesthesia were not accompanied by a decrease in rSO 2 . Aminophylline significantly increased the BIS score during propofol anesthesia, suggesting that aminophylline can antagonize, at least in part, the sedative actions of propofol. 47,8 ± 5,4 à 35,0 ± 4,5 cinq minutes après l'injection (P < 0,001 vs témoin) pendant l'anesthésie au propofol, tandis que la rSO 2 n'a pas changé. De même,1,1 %) a diminué le BIS de 42,5 ± 7,5 à 27,8 ± 6,9 (P < 0,001) Objectif : Comparer l'influence du midazolam, de l'isoflurane et de l'aminophylline (qui peut contrer l'action anesthésique) sur l'index bispectral (BIS) et

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“…Anesthetic drugs inhibit neuronal activity in the brain and affect cerebral metabolism [4][5][6]. Brain oxygenation levels can be monitored to evaluate cerebral metabolism using nearinfrared spectroscopy (NIRS) [7,8]. NIRS is a widely used noninvasive optical technique that allows the measurement of hemoglobin oxygenation to evaluate oxygen consumption within living tissue based on the differences in near-infrared (NIR) absorption [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Monitoring of cerebral oxygenation and local field potential with a variation of isoflurane concentration in a rat model

Choi

Shin

Kim

et al. 2016

Biomed. Opt. Express

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Abstract:We aimed to investigate experimentally how anesthetic levels affect cerebral metabolism measured by near-infrared spectroscopy (NIRS) and to identify a robust marker among NIRS parameters to discriminate various stages of anesthetic depth in rats under isoflurane anesthesia. In order to record the hemodynamic changes and local field potential (LFP) in the brain, fiber-optic cannulae and custom-made microelectrodes were implanted in the frontal cortex of the skull. The NIRS and LFP signals were continuously monitored before, during and after isoflurane anesthesia. As isoflurane concentration is reduced, the level of oxyhemoglobin and total hemoglobin concentrations of the frontal cortex decreased gradually, while deoxyhemoglobin increased. The reflectance ratio between 730nm and 850nm and burst suppression ratio (BSR) correspond similarly with the change of oxyhemoglobin during the variation of isoflurane concentration. These results suggest that NIRS signals in addition to EEG may provide a possibility of developing a new anesthetic depth index. . 12(4), 1019-1029 (1996). 15. S. Ahn, T. Nguyen, H. Jang, J. G. Kim, and S. C. Jun, "Exploring neuro-physiological correlates of drivers' mental fatigue caused by sleep deprivation using simultaneous EEG, ECG, and fNIRS data," Front. Hum. Neurosci. 10, 219 (2016). 16. J. G. Kim, J. Lee, J. Roe, B. J. Tromberg, M. Brenner, and T. J. Walters, "Hemodynamic changes in rat leg muscles during tourniquet-induced ischemia-reperfusion injury observed by near-infrared spectroscopy,"

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Vital capacity induction with 8% sevoflurane and N 2 O causes cerebral hyperemia

Abstract: Vital capacity inhalation of 8% sevoflurane produces a faster loss of eyelash reflex than does 5% sevoflurane or propofol, but increases cerebral blood volume.

Cited by 9 publications

References 16 publications

Near-Infrared Spectroscopy for the Evaluation of Anesthetic Depth

Near-Infrared Spectroscopy for the Evaluation of Anesthetic Depth

Ľindex bispectral et la saturation en oxygène du sang cérébral régional pendant ľanesthésie au propofol/N2O

Monitoring of cerebral oxygenation and local field potential with a variation of isoflurane concentration in a rat model

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