Vitamin A and Breast Cancer Survival: A Systematic Review and Meta-analysis

He, Jianxing; Gu, Yuanting; Zhang, Shaojin

doi:10.1016/j.clbc.2018.07.025

Cited by 45 publications

(29 citation statements)

References 35 publications

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“…2, 19p13.2, 8q21.11, 14q24.1, 14q24.1, 19q13.42, 2p24.2 and 8q12.1 genomic regions, respectively. They mostly participate in retinol dehydrogenation which is highly in consistence with He et.al findings which reported the dietary intake of β-carotene to be significantly associated with improved breast cancer overall survival 37 . It is noteworthy that dietary β-carotene is bio-converted to retinol (also known as vitamin A) which is essential for "the promotion of general growth, maintenance of visual function, regulation of differentiation of epithelial tissues, and embryonic development" 38 .…”

Section: Discussionsupporting

confidence: 69%

Identification of significantly mutated subnetworks in the breast cancer genome

Ajwad

Domaratzki

Liu

et al. 2021

Sci Rep

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Recent studies showed that somatic cancer mutations target genes that are in specific signaling and cellular pathways. However, in each patient only a few of the pathway genes are mutated. Current approaches consider only existing pathways and ignore the topology of the pathways. For this reason, new efforts have been focused on identifying significantly mutated subnetworks and associating them with cancer characteristics. We applied two well-established network analysis approaches to identify significantly mutated subnetworks in the breast cancer genome. We took network topology into account for measuring the mutation similarity of a gene-pair to allow us to infer the significantly mutated subnetworks. Our goals are to evaluate whether the identified subnetworks can be used as biomarkers for predicting breast cancer patient survival and provide the potential mechanisms of the pathways enriched in the subnetworks, with the aim of improving breast cancer treatment. Using the copy number alteration (CNA) datasets from the METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) study, we identified a significantly mutated yet clinically and functionally relevant subnetwork using two graph-based clustering algorithms. The mutational pattern of the subnetwork is significantly associated with breast cancer survival. The genes in the subnetwork are significantly enriched in retinol metabolism KEGG pathway. Our results show that breast cancer treatment with retinoids may be a potential personalized therapy for breast cancer patients since the CNA patterns of the breast cancer patients can imply whether the retinoids pathway is altered. We also showed that applying multiple bioinformatics algorithms at the same time has the potential to identify new network-based biomarkers, which may be useful for stratifying cancer patients for choosing optimal treatments.

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Section: Discussionsupporting

confidence: 69%

Identification of significantly mutated subnetworks in the breast cancer genome

Ajwad

Domaratzki

Liu

et al. 2021

Sci Rep

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“…Several studies have assessed the association between antioxidants and the incidence or prognosis of BC [ 7 , 8 , 17 , 20 , 21 , 35 , 36 ]. It is well known that VitC is one of the most common antioxidants found in fruits and vegetables with chemo-preventive effects [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Association of vitamin C intake with breast cancer risk and mortality: a meta-analysis of observational studies

Zhang

et al. 2020

Aging

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The association between vitamin C intake and breast cancer is unclear. This meta-analysis aimed to precisely assess the association of vitamin C intake with breast cancer risk and mortality. We searched the PubMed, Embase, and Web of Science databases up to June 2020 and found 69 studies relevant to breast cancer risk (54 studies) and survival (15 studies). Relative risks and 95% confidence intervals were calculated using the random-effects models. Pooled results suggested that the highest versus lowest vitamin C intake was significantly associated with a lower risk of breast cancer incidence (Relative Risk = 0.86; 95% confidence interval, 0.81–0.92). Dietary vitamin C but not supplements was found to reduce breast cancer risk (Relative Risk = 0.89; 95% confidence interval, 0.82–0.96). For the highest versus lowest vitamin C intake, the pooled hazard risk for breast cancer-specific mortality was 0.78 (95% confidence interval, 0.69–0.88), totality mortality was 0.82 (95% confidence interval, 0.74–0.91), and recurrence was 0.81 (95% confidence interval, 0.67–0.99). Our analysis suggests that higher vitamin C intake is significantly associated with reduced breast cancer incidence and mortality. However, the intake of vitamin C supplements has no significant effect on breast cancer prevention.

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“…(18). Furthermore, a metaanalysis of 10 studies (8 cohort, 1 clinical trial, and 1 pooled study) with 19,450 breast cancer cases, has shown that the dietary intake of β-carotene is significantly associated with improved breast cancer survival with a 30% reduction in the odds of dying from breast cancer [summary HR=0.70 (95%CI=0.50-0.99, I 2 =37.5%) for the highest versus lowest intake of β-carotene] (19). In a large prospective analysis with 20 years of follow-up, women with high plasma carotenoids were at reduced breast cancer risk, particularly for more aggressive and ultimately fatal disease.…”

Section: Methodsmentioning

confidence: 99%