Vitamin A and E Homologues Impacting the Fate of Acrylamide in Equimolar Asparagine-Glucose Model System

Abstract

This study aims to evaluate the influence of Vitamin A and E homologues toward acrylamide in equimolar asparagine-glucose model system. Vitamin A homologue as β-carotene (BC) and five Vitamin E homologues, i.e., α-tocopherol (AT), δ-tocopherol (DT), α-tocotrienol (ATT), γ-tocotrienol (GTT), and δ-tocotrienol (DTT), were tested at different concentrations (1 and 10 µmol) and subjected to heating at 160 °C for 20 min before acrylamide quantification. At lower concentrations (1 µmol; 431, 403, 411 ppm, respectively), AT, DT, and GTT significantly increase acrylamide. Except for DT, enhancing concentration to 10 µmol (5370, 4310, 4250, 3970, and 4110 ppm, respectively) caused significant acrylamide formation. From linear regression model, acrylamide concentration demonstrated significant depreciation over concentration increase in AT (Beta = −83.0, R2 = 0.652, p ≤ 0.05) and DT (Beta = −71.6, R2 = 0.930, p ≤ 0.05). This study indicates that different Vitamin A and E homologue concentrations could determine their functionality either as antioxidants or pro-oxidants.

Machine learning prediction of dual and dose-response effects of flavone carbon and oxygen glycosides on acrylamide formation

“…Especially, ascorbic acid, a typical water-soluble antioxidant, exerted an inhibitory effect up to 58% within an addition range of 0.2–1.2%, whereas showed a promotion effect with the addition percentage of 1.5% in an asparagine-glucose model system. Furthermore, an equimolar asparagine-glucose model system indicates that different vitamin A and E homologue concentrations could determine their functionality either as antioxidants or pro-oxidants ( 34 ).…”