Vitamin A and glutathione-mediated free radical damage: Competing reactions with polyunsaturated fatty acids and vitamin C

D'Aquino, Massimo; Dunster, Christina; Willson, R. L.

doi:10.1016/0006-291x(89)91369-7

Cited by 64 publications

(33 citation statements)

References 7 publications

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“…Both vitamin A and zinc have an antioxidant role in a range of animals and in vitro models (Bray and Bettger, 1990;D'Aquino et al, 1989;Livrea et al, 1995). In this study, zinc supplementation was associated with a decrease in lipid peroxides measured by thiobarbituric acid reactive substances (TBA-RS) after adjusting for baseline levels of plasma lipid peroxides and vitamin A, sex and smoking habits.…”

Section: Discussionmentioning

confidence: 61%

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Zinc supplementation and plasma lipid peroxides in an elderly population

et al. 1997

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Objective: To determine the effect of vitamin A, zinc or both on plasma lipid peroxides in a healthy elderly population. Design: Double-blind randomized controlled trial supplementation of vitamin A and zinc. Setting: Public home for elderly people, in Rome, Italy. Subjects: A total of 178 residents of a Public home for elderly people were evaluated regarding health and nutritional status. 136 gave a written consensus to participate in the trial and were randomized in four groups of treatment. 118 elderly completed the trial. Interventions: Three months supplementation of the following treatments: (1) vitamin A (800 mg retinol palmitate); (2) zinc (25 mg zinc as sulphate); (3) vitamin A and zinc (800 mg retinol palmitate and 25 mg zinc as sulphate); (4) placebo (starch containing capsules). Main outcome measures: Plasma lipid peroxides (TBA-RS) were measured before and after supplementation. Results: Zinc supplementation was associated with a decrease in plasma lipid peroxides (b 7 0.19; 95% con®dence levels: 70.37, 70.002; p-value 0.05) after adjusting for sex, smoking habits, baseline plasma lipid peroxides and vitamin A plasma levels. Conclusions: Zinc supplementation decreased plasma lipid peroxides while vitamin A had no effect in this elderly population. Adequate zinc intake or supplementation could play an important role in the prevention and/ or modulation of diseases in the elderly people.

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Section: Discussionmentioning

confidence: 61%

“…Zinc and vitamin A intake, whose intake is often suboptimal in the elderly (Bogden et al, 1987;Ferro-Luzzi et al, 1988) may function as antioxidants (Bray and Bettger, 1990;D'Aquino et al, 1989). There has been little in vivo research undertaken to determine whether zinc and vitamin A provide antioxidant protection in elderly.…”

Section: Introductionmentioning

confidence: 99%

Zinc supplementation and plasma lipid peroxides in an elderly population

et al. 1997

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“…[23][24][25][26] However, most antioxidants are known to react with thiyl radicals and generate the corresponding thiol in organic or aqueous solutions. [27][28][29][30] In a previous study, using MLVs as model moieties in which the antioxidants were incorporated, the inhibition of the isomerization process attributed to antioxidants increased in the order of α-tocopherol < ascorbate < all-trans-retinol acetate. In those experiments the same amount of the antioxidants was used and the thiol/antioxidant molar ratio was always 150:1.…”

Section: Resultsmentioning

confidence: 99%

Biomimetic chemistry on the protection of cis phospholipid from the thiyl radical isomerization by common antioxidants

Lykakis¹,

Ferreri²,

Chatgilialoglu³

2015

Arkivoc

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Dedicated to Prof. Michael Orfanopoulos on the occasion of his 67th birthday and retirement, and for being a splendid teacher, scientist and friend DOI: http://dx.doi.org/10.3998/ark.5550190.p008.984 AbstractIn this paper the evaluation of cis phospholipids geometry protection from the thiyl radical isomerization in the presence of common antioxidants is studied. Thus, large unilamellar vesicles (LUVs) of glycerophospholipids containing oleate moieties were used as biomimetic model to demonstrate that hydrophilic ascorbic acid and urate, and hydrophobic all-trans retinol acetate and α-tocopherol, are able to inhibit cis-trans isomerization from the thiyl radicals that are known to react as efficient isomerizing species. The synergistic effect obtained by a mix of the hydrophilic and hydrophobic antioxidants at in vivo concentrations is also proved to exert an extraordinary protection for the integrity of cis lipid geometry.

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“…However, in polar solvents, the reaction can proceed via addition, hydrogen abstraction and electron-transfer pathways (Eqs. [1][2][3] depending on the type of the reacting free radical and the carotenoid [1][2][3]5,16,17]. Time-resolved peroxyl radical studies with carotenoids in micelles and microemulsions are very limited [18,19] although they can be used as simple models for cellular membranes [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Peroxyl radical reactions with carotenoids in microemulsions: Influence of microemulsion composition and the nature of peroxyl radical precursor

El‐Agamey

McGarvey

2016

Free Radical Biology and Medicine

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Cite this article as: Ali El-Agamey and David J. Mcgarvey, Peroxyl radical reactions with carotenoids in microemulsions: Influence of microemulsion composition and the nature of peroxyl radical precursor, Free Radical Biology and Medicine, http://dx.doi.org/10.1016/j.freeradbiomed. 2015.10.427 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractThe reactions of acetylperoxyl radicals with different carotenoids (7,7'-dihydro-β-carotene and ζ-carotene) in SDS and CTAC microemulsions of different compositions were investigated using laser flash photolysis (LFP) coupled with kinetic absorption spectroscopy. The primary objective of this study was to explore the influence of microemulsion composition and the type of surfactant used on the yields and kinetics of various transients formed from the reaction of acetylperoxyl radicals with carotenoids. Also, the influence of the site (hydrocarbon phases or aqueous phase) of generation of the peroxyl radical precursor was examined by using 4-acetyl-4-phenylpiperidine hydrochloride

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Vitamin A and glutathione-mediated free radical damage: Competing reactions with polyunsaturated fatty acids and vitamin C

Cited by 64 publications

References 7 publications

Zinc supplementation and plasma lipid peroxides in an elderly population

Zinc supplementation and plasma lipid peroxides in an elderly population

Biomimetic chemistry on the protection of cis phospholipid from the thiyl radical isomerization by common antioxidants

Peroxyl radical reactions with carotenoids in microemulsions: Influence of microemulsion composition and the nature of peroxyl radical precursor

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