Fredrick Hopkins discovered Vitamin A, a fat-soluble 20 carbon unit molecule acquired through natural sources like carrots and synthetic options like gelatin capsules or supplements. It has a vital role in developing the human eye, early stages of lung formation, and immune system. Deficiency of vitamin A causes Xerophthalmia, can lead to night blindness, and severe conditions advance to permanent blindness. On the other side, toxicity results in skin irritation and teratogenicity in newborn babies. The action of Retinoic acid as a neurotransmitter and the effect of different doses of Vitamin A on morbidity are essential topics that make scientists curious. This paper describes Vitamin A history, deficiency accompanied by toxicity, role, and importance for the eye and the treatment of SARS-CoV-2.