Vitamin A deficiency and bone growth

Hayes, K. C.; Cousins, R. J.

doi:10.1007/bf02196191

Cited by 11 publications

(6 citation statements)

References 16 publications

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“…Both calves in this study had papilledema, accompanied by vision loss. Changes in the optic nerve and the optic nerve head have been reported to be caused by necrosis resulting from stenosis of the optic canal and an increase in cerebrospinal fluid (CSF) pressure in hypovitaminosis A [ 3 , 4 ]. In growing animals, an increase in CSF pressure is a significant event brought about by hypovitaminosis A [ 1 ]; faulty absorption and increased resistance to outflow are the possible causes for this increase [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, disproportionate bone growth related to hypovitaminosis A has been reported in some studies as an even more important change in growing animals because it affects the remodeling of various foramina (including the optic canal), and leads to vascular impairment of the optic nerve [ 3 , 4 ]. In addition, retinal changes, including retinal degeneration and dysplasia, are known causes of blindness [ 3 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

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Ocular abnormalities associated with hypovitaminosis A in Hanwoo calves: a report of two cases

Kang

Park²,

Seo

2017

The Journal of Veterinary Medical Science

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This study reports on two Hanwoo (a native Korean breed of cattle) calves, a 3- and 6-month-old presenting with diarrhea, anorexia and blindness. Ophthalmoscopic examination revealed bilateral papilledema in both calves. Reverse-transcription polymerase chain reaction tests for bovine viral diarrhea virus, rotavirus and coronavirus were all negative. The levels of serum vitamin A in the two affected calves were 0.317 µg/dl and 0.481 µg/dl, respectively. These values are much lower than the normal vitamin A levels; therefore, the calves were diagnosed with hypovitaminosis A.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ocular abnormalities associated with hypovitaminosis A in Hanwoo calves: a report of two cases

Kang

Park²,

Seo

2017

The Journal of Veterinary Medical Science

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“…Thus, the effect of RA on craniofacial skeletal development is complex (Johnston and Bronsky 1995), and it is important to elucidate the pathogenesis of VAD craniofacial skeletal deformity to guide clinical medication of VAD patients and provide evidence for the positive effect of RA intake on bone. VAD patients generally exhibit parietal bone agenesis, coarse and poorly remodeled cranial bone, and abnormal intramembranous osteogenesis, especially on the medial border of the mandible (Hayes and Cousins 1970). Maternal and postnatal dietary VAD mice also exhibited abnormal intramembranous osteogenesis and defective bone formation (Hayes and Cousins 1970).…”

Section: Discussionmentioning

confidence: 99%

“…VAD patients generally exhibit parietal bone agenesis, coarse and poorly remodeled cranial bone, and abnormal intramembranous osteogenesis, especially on the medial border of the mandible (Hayes and Cousins 1970). Maternal and postnatal dietary VAD mice also exhibited abnormal intramembranous osteogenesis and defective bone formation (Hayes and Cousins 1970). Using our model, we observed a similar phenotype with cranial bone hypomineralization, mandibular deformity, and clavicular hypoplasia.…”

Section: Discussionmentioning

confidence: 99%

Osteoblastic RAR Inhibition Causes VAD-Like Craniofacial Skeletal Deformity

et al. 2023

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Retinoid signaling disorders cause craniofacial deformity, among which infants with maternal vitamin A deficiency (VAD) exhibited malformation of the eye, nose, palate, and parietal and jaw bone. Previous research uncovered the pathogenesis of eye defect and cleft palate of VAD in mice, but the studies on craniofacial skeletal deformity met obstacles, and the cell/lineage and underlying mechanism remain unclear. The retinoic acid receptor (RAR) is the key transcription factor in retinoid signaling, but individual knockout cannot simulate pathway inhibition. Here, we conditionally expressed dominant-negative RARα mutation ( dnRARα) in osteoblasts to specifically inhibit the transcription activity of RAR in mice, which mimics the craniofacial deformities caused by VAD in clinical cases: hypomineralization of cranial bones, mandibular deformity, and clavicular hypoplasia. Furthermore, we performed 3-dimensional reconstruction based on micro–computed tomography and confirmed the abnormalities in the shape, size, and ossification of craniofacial bones due to osteoblastic RAR inhibition. Histological analysis indicated that inhibition of RAR in osteoblasts impaired both bone formation and bone resorption, which was confirmed by transcriptome sequencing of the calvaria. Furthermore, mechanism investigation showed that inhibition of RAR in osteoblasts directly decreased osteoblast differentiation in a cell-autonomous manner by impairing osteogenic gene transcription and also inhibited osteoclast differentiation via osteoblast–osteoclast crosstalk by impairing Rankl transcription. In summary, osteoblastic RAR activity is critical to craniofacial skeletal development, and its dysfunction leads to skeletal deformities mimicking VAD craniofacial defects, providing a new insight for VAD pathogenesis.

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“…The recent works of Howell and Thompson (1967a and b), Hayes and Cousins (1970) and Gallina ^ al. (1970) have reinvestigated the effect of vitamin A deficiency on bone development and they support the work of Mellanby.…”

Section: Gurcay Et Al (1950) Studied the Utilization Of Crystalline mentioning

confidence: 97%

Effect of dietary vitamin A, ascorbic acid and their interaction on turkey bone mineralization

Dorr

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Vitamin A deficiency and bone growth

Cited by 11 publications

References 16 publications

Ocular abnormalities associated with hypovitaminosis A in Hanwoo calves: a report of two cases

Ocular abnormalities associated with hypovitaminosis A in Hanwoo calves: a report of two cases

Osteoblastic RAR Inhibition Causes VAD-Like Craniofacial Skeletal Deformity

Effect of dietary vitamin A, ascorbic acid and their interaction on turkey bone mineralization

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