Vitamin A deficiency enhances docosahexaenoic and Osbond acids in liver of rats fed an α‐linoleic acid‐adequate diet

Zhou, Dequan; Ghebremeskel, Kebreab; Crawford, Michael; Reifen, Ram

doi:10.1007/s11745-006-5090-x

Cited by 14 publications

(5 citation statements)

References 35 publications

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“…Supporting the notion of a protective or compensatory response to HSC activation is the increased concentration of hepatic DHA we observed, which is correlated with retinol loss [ 54 ]. DHA and arachidonic acid bind RXRα and are activating ligands [ 9 ] and increased RXRα expression inhibits HSC activation and suppresses markers of fibrosis in rats [ 55 ].…”

Section: Discussionsupporting

confidence: 76%

Spaceflight Activates Lipotoxic Pathways in Mouse Liver

et al. 2016

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Spaceflight affects numerous organ systems in the body, leading to metabolic dysfunction that may have long-term consequences. Microgravity-induced alterations in liver metabolism, particularly with respect to lipids, remain largely unexplored. Here we utilize a novel systems biology approach, combining metabolomics and transcriptomics with advanced Raman microscopy, to investigate altered hepatic lipid metabolism in mice following short duration spaceflight. Mice flown aboard Space Transportation System -135, the last Shuttle mission, lose weight but redistribute lipids, particularly to the liver. Intriguingly, spaceflight mice lose retinol from lipid droplets. Both mRNA and metabolite changes suggest the retinol loss is linked to activation of PPARα-mediated pathways and potentially to hepatic stellate cell activation, both of which may be coincident with increased bile acids and early signs of liver injury. Although the 13-day flight duration is too short for frank fibrosis to develop, the retinol loss plus changes in markers of extracellular matrix remodeling raise the concern that longer duration exposure to the space environment may result in progressive liver damage, increasing the risk for nonalcoholic fatty liver disease.

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Section: Discussionsupporting

confidence: 76%

Spaceflight Activates Lipotoxic Pathways in Mouse Liver

et al. 2016

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“…Recently, a PPARR ligand, rosiglitazone, has been reported to increase DHA and EPA in adipose tissue but not in the liver, in a mouse model of type II diabetes (30). In addition, vitamin A deficiency has also been reported to enhance the proportion of DHA in the liver of rats fed 18:3n-3 (31). Thus, DHA biosynthesis has been reported to be regulated by synthetic compounds and nutritional factors.…”

Section: Resultsmentioning

confidence: 99%

Fucoxanthin and Fucoxanthinol Enhance the Amount of Docosahexaenoic Acid in the Liver of KKAy Obese/Diabetic Mice

Tsukui

Konno

Hosokawa

et al. 2007

J. Agric. Food Chem.

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This study examined the effect of dietary fucoxanthin or fucoxanthinol on the amount of docosahexaenoic acid (DHA) in the liver of KKAy mice, a model for obese/type II diabetes. In the first experiment, mice were fed diets containing crude fucoxanthin or glyceroglycolipid for 4 weeks. Results showed a significant increase in the level of DHA in mice fed 0.53% crude fucoxanthin, from 2.3% in control mice to 5.1% of fatty acid composition of total liver lipids. On the other hand, in mice fed crude glyceroglycolipid, the level of DHA as a proportion of total liver fatty acids remained unchanged. To clarify the enhancement of hepatic DHA, in the second experiment, KKAy mice were fed a diet containing purified fucoxanthin or its deacetylated derivative, fucoxanthinol. Results from a quantitative analysis using an internal standard showed that in mice fed 0.2% fucoxanthin, the amount of hepatic DHA was 2-fold higher than in control mice, whereas DHA levels in the small intestine remained unchanged. Furthermore, 0.2% fucoxanthinol led to 1.8- and 1.2-fold increases in the amount of hepatic DHA and arachidonic acid compared to control mice, respectively. These results indicate for the first time that dietary fucoxanthin and fucoxanthinol enhance the amount of DHA in the liver of KKAy mice.

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“…The conversion of EPA from ALA (n-3) or AA from LA (n-6) depends on the amount of substrate for the delta-6-desaturase enzyme (Zhou et al 2006). For this reason, the ratio of n-6/n-3 in the substrate determines the enzyme competition.…”

Section: Plasma Fatty Acidsmentioning

confidence: 99%

The application of probiotics and flaxseed promotes metabolism of n-3 polyunsaturated fatty acids in pigs

Sopková

Hertelyová

Andrejčáková

et al. 2016

Journal of Applied Animal Research

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The effect of combining probiotics (Lactobacillus plantarum and Lactobacillus fermentum) with flaxseed (a source of n-3 PUFAs) on the lipid metabolism and long-chain fatty acid profile of conventional piglets after weaning was studied. The levels of total lipids and high-density lipoproteins cholesterol decreased from Day 7 post-weaning, whereas levels of low-density lipoproteins cholesterol, total cholesterol and triglycerides did not change significantly in piglets with supplemented diet. The levels of alphalinolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) increased seven days post-weaning; however, the levels of dihomogamma-linolenic acid and arachidonic acid (AA) were lower and linoleic acid (LA) higher in synbioticsfed piglets compared with controls. This study demonstrates the efficacy of conversion of ALA to EPA and DHA, where delta-6-desaturase was predominantly used for n-3 polyunsaturated fatty acid synthesis from ALA at the expense of n-6 PUFAs from LA, which caused rapid increase in EPA/AA ratio on Day 14 after weaning. Combination of probiotic cheese and flaxseed is a good dietary supplement for piglets before weaning, helping them to adapt to change in diet more easily by regulating changes in lipid metabolism and vitality, and reducing the likelihood of chronic diseases. ARTICLE HISTORY

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Vitamin A deficiency enhances docosahexaenoic and Osbond acids in liver of rats fed an α‐linoleic acid‐adequate diet

Cited by 14 publications

References 35 publications

Spaceflight Activates Lipotoxic Pathways in Mouse Liver

Spaceflight Activates Lipotoxic Pathways in Mouse Liver

Fucoxanthin and Fucoxanthinol Enhance the Amount of Docosahexaenoic Acid in the Liver of KKAy Obese/Diabetic Mice

The application of probiotics and flaxseed promotes metabolism of n-3 polyunsaturated fatty acids in pigs

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