Vitamin A, folate, and choline as a possible preventive intervention to fetal alcohol syndrome

Ballard, Mark; Sun, Muxin; Ko, Jenny J.

doi:10.1016/j.mehy.2012.01.014

Cited by 45 publications

(36 citation statements)

References 38 publications

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“…Animal models of FAS/FASD have been useful in probing the mechanisms for ethanol-induced congenital defects and in investigating potential preventative therapeutics such as folic acid, choline, and myoinositol (Smith, 1997; Sant'Anna and Tosello, 2006; Serrano et al, 2010; Wilson and Cudd, 2011; Ballard et al, 2012; Cole et al, 2012). …”

Section: Application Of Biophotonic Tools To Study the Genesis Of Chdmentioning

confidence: 99%

Capturing structure and function in an embryonic heart with biophotonic tools

Karunamuni

Ford

et al. 2014

Front. Physiol.

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Disturbed cardiac function at an early stage of development has been shown to correlate with cellular/molecular, structural as well as functional cardiac anomalies at later stages culminating in the congenital heart defects (CHDs) that present at birth. While our knowledge of cellular and molecular steps in cardiac development is growing rapidly, our understanding of the role of cardiovascular function in the embryo is still in an early phase. One reason for the scanty information in this area is that the tools to study early cardiac function are limited. Recently developed and adapted biophotonic tools may overcome some of the challenges of studying the tiny fragile beating heart. In this chapter, we describe and discuss our experience in developing and implementing biophotonic tools to study the role of function in heart development with emphasis on optical coherence tomography (OCT). OCT can be used for detailed structural and functional studies of the tubular and looping embryo heart under physiological conditions. The same heart can be rapidly and quantitatively phenotyped at early and again at later stages using OCT. When combined with other tools such as optical mapping (OM) and optical pacing (OP), OCT has the potential to reveal in spatial and temporal detail the biophysical changes that can impact mechanotransduction pathways. This information may provide better explanations for the etiology of the CHDs when interwoven with our understanding of morphogenesis and the molecular pathways that have been described to be involved. Future directions for advances in the creation and use of biophotonic tools are discussed.

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Section: Application Of Biophotonic Tools To Study the Genesis Of Chdmentioning

confidence: 99%

Capturing structure and function in an embryonic heart with biophotonic tools

Karunamuni

Ford

et al. 2014

Front. Physiol.

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“…49 Recent experimental work with animals exposed to alcohol during gestation found that a combination of postnatal choline, folate, and vitamin A reversed many of the learning problems in the animals even if they were adults when treatment began. 50,51 One-fifth of school age children and adults with FASD are diagnosed with anxiety, and many receive neuroleptic drugs for this. 51 Other evidence-based interventions include "Math Interactive Learning Experience," "Good Buddies," "Language to Literacy Program," and "USFA Kids."…”

Section: Fetal Alcohol Spectrum Disordersmentioning

confidence: 99%

Health Care for Youth Involved with the Correctional System

Perry

Morris

2014

Primary Care: Clinics in Office Practice

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“…Folate deficiency is proposed to be causally linked to FAS, since alcoholism induces folate deficiency and increases the risk for embryonic anomalies (reference 2 and references therein). Folate supplementation is considered a potential preventive intervention to FAS, although the underlying mechanism of this protective effect remains elusive (3).…”

mentioning

confidence: 99%

Ethanol-Induced Upregulation of 10-Formyltetrahydrofolate Dehydrogenase Helps Relieve Ethanol-Induced Oxidative Stress

Hsiao

Lin

Chung

et al. 2014

Molecular and Cellular Biology

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Alcoholism induces folate deficiency and increases the risk for embryonic anomalies. However, the interplay between ethanol exposure and embryonic folate status remains unclear. To investigate how ethanol exposure affects embryonic folate status and one-carbon homeostasis, we incubated zebrafish embryos in ethanol and analyzed embryonic folate content and folate enzyme expression. Exposure to 2% ethanol did not change embryonic total folate content but increased the tetrahydrofolate level approximately 1.5-fold. The expression of 10-formyltetrahydrofolate dehydrogenase (FDH), a potential intracellular tetrahydrofolate reservoir, was increased in both mRNA and protein levels. Overexpressing recombinant FDH in embryos alleviated the ethanol-induced oxidative stress in ethanol-exposed embryos. Further characterization of the zebrafish fdh promoter revealed that the ؊124/؉40 promoter fragment was the minimal region required for transactivational activity. The results of site-directed mutagenesis and binding analysis revealed that Sp1 is involved in the basal level of expression of fdh but not in ethanol-induced upregulation of fdh. On the other hand, CEBP␣ was the protein that mediated the ethanol-induced upregulation of fdh, with an approximately 40-fold increase of fdh promoter activity when overexpressed in vitro. We concluded that upregulation of fdh involving CEBP␣ helps relieve embryonic oxidative stress induced by ethanol exposure.

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Vitamin A, folate, and choline as a possible preventive intervention to fetal alcohol syndrome

Cited by 45 publications

References 38 publications

Capturing structure and function in an embryonic heart with biophotonic tools

Capturing structure and function in an embryonic heart with biophotonic tools

Health Care for Youth Involved with the Correctional System

Ethanol-Induced Upregulation of 10-Formyltetrahydrofolate Dehydrogenase Helps Relieve Ethanol-Induced Oxidative Stress

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