Vitamin a in Health Foods

Adams, Jad; Shenton, Joan

doi:10.1016/s0140-6736(85)91180-8

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…Moreover, fluorescence intensity in the lungs and kidneys at 72 h after intravenous injection of PPG-cRGD NPs highly increased, presumably because of the mechanical entrapment of larger-sized NPs in the lung capillaries [ 26 ]. However, this may not be a critical problem as the NP composition is based on poly(amino acids), which are known for their superior biocompatibility and non-toxic nature [ 17 ]. Furthermore, higher kidney accumulation can be attributed to higher integrin α v β 3 binding affinity in the kidneys [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…Amphiphilic graft copolymers received increased attention in the past decade owing to their potential applications in biosensors and drug delivery [ 15 , 16 ]. Among them, poly(amino acids) are well known to possess excellent biomedical applicability because of their biocompatibility, non-toxic nature, and biodegradability [ 17 ]. Poly(succinimide) (PSI) derivatives, such as poly(hydroxyethyl- aspartamide) (PHEA) and poly(aspartic acid), displayed typical amphiphilic characteristics in aqueous environment [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Design of an Amphiphilic Poly(aspartamide)-Mediated Self-Assembled Nanoconstruct for Long-Term Tumor Targeting and Bioimaging

2019

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Biodegradable polymers have been developed for the targeted delivery of therapeutics to tumors. However, tumor targeting and imaging are usually limited by systemic clearance and non-specific adsorption. In this study, we used poly(amino acid) derivatives, such as poly(succinimide), to synthesize a nanomicelle-forming poly(hydroxyethylaspartamide) (PHEA, P) modified sequentially with octadecylamine, polyethylene glycol (PEG, P), and glycine (G) to design PHEA-PEG-glycine (PPG) nanoparticles (NPs). These PPG NPs were further tethered to cyclic Arg-Gly-Asp (cRGD) sequences for formulating tumor-targeting PPG-cRGD NPs, and then loaded with IR-780 dye (PPG-cRGD-IR-780) for visualizing tumor homing. cRGD cloaked in PPG NPs could bind specifically to both tumor endothelium and cancer cells overexpressing αvβ3 integrins. PPG-cRGD NPs exhibited enhanced physiological stability, cellular viability, and targeted intracellular uptake in cancer cells. In addition, PPG-cRGD NPs offered enhanced systemic circulation, leading to preferential tumor targeting and prolonged fluorescence tumor imaging for nearly 30 days. Nevertheless, non-targeted formulations demonstrated premature systemic clearance with short-term tumor imaging. Histochemical analysis showed no damage to normal organs, reaffirming the biocompatibility of PHEA polymers. Overall, our results indicated that PPG-cRGD NPs, which were manipulated to obtain optimal particle size and surface charge, and were complemented with tumor targeting, could improve the targeted and theranostic potential of therapeutic delivery.

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Section: Resultsmentioning

confidence: 99%