Vitamin A in Osteo- and Rheumatoid Arthritis

Fairney, Angela; Patel, Kalpana; Fish, D.E.; Seifert, Martin

doi:10.1093/rheumatology/27.4.329

Cited by 4 publications

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“…Vitamin A Fairney et al (1988) reported a difference in vitamin A metabolism or intake between patients with RA and controls: serum retinol and retinol binding protein levels were lower in RA than in matched control sera P , 0´01 and in OA patients P , 0´001X b-Carotene If the diet of healthy volunteers is supplemented with b-carotene, significant increases can be demonstrated in the percentage of monocytes expressing the major histo compatibility class II molecule, HLA-DR, and the adhesion molecules intracellular adhesion molecule-1 and leucocyte function-associated molecule . b-Carotene may also quench singlet oxygen which may reduce the free radical burden and protect membrane lipids from peroxidation.…”

Section: Clinical Studies Of Dietary Antioxidants In Rheumatoid Arthrmentioning

confidence: 99%

Antioxidants and fatty acids in the amelioration of rheumatoid arthritis and related disorders

2001

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The generation of reactive oxygen species (free radicals) is an important factor in the development and maintenance of rheumatoid arthritis in humans and animal models. One source of free radicals is nitric oxide produced within the synoviocytes and chondrocytes and giving rise to the highly toxic radical peroxynitrite. Several cytokines, including tumour necrosis factor-α (TNFα) are involved in the formation of free radicals, partly by increasing the activity of nitric oxide synthase. Indeed, nitric oxide may mediate some of the deleterious effects of cytokines on bone resorption. Aspirin, tetracyclines, steroids and methotrexate can suppress nitric oxide synthase. Dietary antioxidants include ascorbate and the tocopherols and beneficial effects of high doses have been reported especially in osteoarthritis. There is also evidence for beneficial effects of β-carotene and selenium, the latter being a component of the antioxidant enzyme glutathione peroxidase. The polyunsaturated fatty acids (PUFA) include then-3 compounds, some of which are precursors of eicosanoid synthesis, and then-6 group which can increase formation of the pro-inflammatory cytokines TNFα and interleukin-6, and of reactive oxygen species. Some prostaglandins, however, suppress cytokine formation, so thatn-3 PUFA often oppose the inflammatory effects of somen-6-PUFA. γ-linolenic acid (GLA) is a precursor of prostaglandin E1, a fact which may account for its reported ability to ameliorate arthritic symptoms. Fish oil supplements, rich inn-3 PUFA such as eicosapentaenoic acid have been claimed as beneficial in rheumatoid arthritis, possibly by suppression of the immune system and its cytokine repertoire. Some other oils of marine origin (e.g. from the green-lipped mussel) and a range of vegetable oils (e.g. olive oil and evening primrose oil) have indirect anti-inflammatory actions, probably mediated via prostaglandin E1. Overall, there is a growing scientific rationale for the use of dietary supplements as adjuncts in the treatment of inflammatory disorders such as rheumatoid arthritis and osteoarthritis.

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Section: Clinical Studies Of Dietary Antioxidants In Rheumatoid Arthrmentioning

confidence: 99%