Vitamin A increases nerve growth factor and retinoic acid receptor beta and improves diabetic neuropathy in rats

Hernández‐Pedro, Norma; Granados‐Soto, Vinicio; Ordóñez, Graciela; Pineda, Benjamín; Rangel-López, Edgar; Salazar-Ramiro, Aleli; Arrieta, Óscar; Sotelo, Julio

doi:10.1016/j.trsl.2014.04.002

Cited by 20 publications

(12 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(2013) measured the serum levels of NGF and found lower level of NGF in patients’ with diabetic neuropathy 65 . Recently in 2014 it was observed that Vitamin A increases the level of NGF, which helps in improving diabetic neuropathy in rats 66 .…”

Section: Resultsmentioning

confidence: 99%

T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders

Rani

Mittal

Pramanik

et al. 2017

Sci Rep

View full text Add to dashboard Cite

We performed integrative analysis of genes associated with type 2 Diabetes Mellitus (T2DM) associated complications by automated text mining with manual curation and also gene expression analysis from Gene Expression Omnibus. They were analysed for pathogenic or protective role, trends, interaction with risk factors, Gene Ontology enrichment and tissue wise differential expression. The database T2DiACoD houses 650 genes, and 34 microRNAs associated with T2DM complications. Seven genes AGER, TNFRSF11B, CRK, PON1, ADIPOQ, CRP and NOS3 are associated with all 5 complications. Several genes are studied in multiple years in all complications with high proportion in cardiovascular (75.8%) and atherosclerosis (51.3%). T2DM Patients’ skeletal muscle tissues showed high fold change in differentially expressed genes. Among the differentially expressed genes, VEGFA is associated with several complications of T2DM. A few genes ACE2, ADCYAP1, HDAC4, NCF1, NFE2L2, OSM, SMAD1, TGFB1, BDNF, SYVN1, TXNIP, CD36, CYP2J2, NLRP3 with details of protective role are catalogued. Obesity is clearly a dominant risk factor interacting with the genes of T2DM complications followed by inflammation, diet and stress to variable extents. This information emerging from the integrative approach used in this work could benefit further therapeutic approaches. The T2DiACoD is available at www.http://t2diacod.igib.res.in/.

show abstract

Section: Resultsmentioning

confidence: 99%

T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders

Rani

Mittal

Pramanik

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Moreover, the results of our study showed that increasing NGF level could protect against DPN. Similarly, recent research has suggested that vitamin A may reverse injuries in nerve and restore functional changes caused by DPN upon inducing the expression of NGF [27]. In addition, Li et al have suggested that NGF could alleviate high glucose-induced endoplasmic reticulum (ER) stress which triggers progression of DPN, and that treatment with exogenous NGF could repair the structure of the sciatic nerve in DPN rats [28].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Significance of Serum Levels of Nerve Growth Factor and Brain Derived Neurotrophic Factor in Diabetic Peripheral Neuropathy

Sun

Tang²,

Yin³

et al. 2018

Med Sci Monit

View full text Add to dashboard Cite

BackgroundOur study aimed to explore the levels of nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) in healthy participants, type 2 diabetes mellitus (T2DM) patients, and diabetic peripheral neuropathy (DPN) patients in order to find their effects on DPN.Material/MethodsThe clinical data of 110 healthy participants (age: 57.3±8.2 year, height: 165.4±5.5 cm, weight: 64.1±7.5 kg), 83 T2DM patients (age: 56.5±7.9 year, height: 164.8±6.2 cm, and weight: 63.6±6.6 kg), and 65 DPN patients (age: 58.2±7.3 year, height: 166.7±6.7 cm, weight: 63.1±5.8 kg) were observed. ELISA was applied to detect serum NGF and BDNF levels. Receiver operating characteristic (ROC) curve analysis was performed to evaluate diagnostic value of serum NGF and BDNF levels in DPN. Logistic regression analysis was performed to analyze risk factors for DPN.ResultsSerum NGF and BDNF levels decreased most in DPN patients. Subsequently, we determined that serum NGF and BDNF levels were correlated with: the course of disease for patients, fasting C-peptide (FCP), 2-hour postprandial C-peptide level (2-h PCP), glycosylated hemoglobin level (HbAlc), and 24-hour urinary microalbumin excretion (24-h UME). ROC curve analysis identified high sensitivity, specificity, and accuracy of NGF and BDNF levels on DPN. Serum levels of NGF and BDNF, course of disease, 2-h PCP level, and postprandial blood glucose level were determined to be risk factors for DPN.ConclusionsOur study highlights that serum levels of NGF and BDNF might be associated with the occurrence and development of DPN.

show abstract

“…The immunoexpresion of GFAP was reduced in comparison with taxol and G3 but not reach the control level as some nerve fibers exhibited deformed myelin. This might be secondary to neuroprotective effect of ATRA through stimulation and expression of their nuclear receptors [44] . The expression of these receptors plays an important role in regeneration of both sciatic nerve and Schwann cells.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study between the Effect of Nerve Growth Factor and All-Trans Retinoic Acid versus their combined use on Taxol Induced Peripheral Neuropathy in Adult Male Albino Rat

Abdelrahman

El-Haliem

Elnady

et al. 2019

Egyptian Journal of Histology

View full text Add to dashboard Cite

Introduction: Peripheral neuropathy is a major side effect of chemotherapy. Nerve growth factor induces peripheral nerve regeneration. Retinoids play a significant role in neural growth. Aim of the work: This study aimed to investigate the curative effect of either recombinant human nerve growth factor (rh-NGF) or all trans-retinoic acid (ATRA) alone or together on taxol induced peripheral neuropathy. Materials and methods: Fifty two male albino rats were divided into five groups. Group 1was control group. Group 2 was i.p. injected with taxol (2mg/kg) on days 1, 3, 5, and 7. Group 3 received taxol as in group II then at the 10th day it was i.p. injected with NGF (10ug/kg daily for 20 days). Group 4 received taxol as in group II then at the 10th day it was i.p. injected with ATRA (25mgkg daily for 20 days). Group 5 received taxol as in group II then it was i.p. injected with rh-NGF and ATRA at the 10th day with the same previous dose. Neurophysiological assessment was done for sensory and motor nerve conduction velocity and amplitude as well as thermal pain threshold. Sections of sciatic nerve were prepared for immunohistochemichal and electron microscopic studies. Results: Taxol injected animals exhibited signs of peripheral neuropathy at the 10th day after the first dose of taxol. There was a significant decrease in sensory and motor conduction as well as prolongation in thermal pain threshold. Myelinopathy (splitting, ovoid fragments and invagination) and axonapathy (compressed irregular axoplasm, myelin figures and destructed mitochondria) were seen in the histological examination. Glial fibrillary acidic protein immunoreactive positive cells were significantly increased. rh-NGF and ATRA could ameliorate the electrophysiological and the histological changes. Their combined use had the best result. Conclusion: This study concluded that the use of rh-NGF and ATRA combination could improve taxol induced peripheral neuropathy in male albino rats.

show abstract

Vitamin A increases nerve growth factor and retinoic acid receptor beta and improves diabetic neuropathy in rats

Cited by 20 publications

References 20 publications

T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders

T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders

Diagnostic Significance of Serum Levels of Nerve Growth Factor and Brain Derived Neurotrophic Factor in Diabetic Peripheral Neuropathy

A Comparative Study between the Effect of Nerve Growth Factor and All-Trans Retinoic Acid versus their combined use on Taxol Induced Peripheral Neuropathy in Adult Male Albino Rat

Contact Info

Product

Resources

About