Vitamin A levels are comparable between children with newly diagnosed coeliac disease and non‐coeliac controls

Weintraub, Yael; Ben‐Tov, Amir; Dotan, Gad; Yerushalmy‐Feler, Anat; Weiner, Dror; Levy, Dina; Lubetzky, Ronit; Cohen, Shlomi

doi:10.1111/apa.14873

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…According to their results, 7.5% of patients had a deficiency of vitamin A [10]. Weintraub et al, in a study on active children with CD, did not observe an association between CD and vitamin A deficiency [32]. It should be noted that the lower quantity of fish consumed by our participating adults with active CD may have had a negative effect on their vitamin A levels.…”

Section: Discussionmentioning

confidence: 48%

Investigating the Impact of Vitamin A and Amino Acids on Immune Responses in Celiac Disease Patients

Fallah,

Asri,

Nikzamir

et al. 2024

Diseases

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Amino acids (AAs) and vitamin imbalances are observed in celiac disease (CD). This study evaluated the plasma profile of vitamin A and AAs and the expression level of IL-2, IL-4, IL-10, IL-12 and TGFβ in CD patients. A total of 60 children and adults with CD and 40 healthy controls (HCs) were included. The plasma profile of Vitamin A and AAs and the mRNA expression levels of target genes were assessed. Active adult patients exhibited a decrease in Vitamin A levels (p = 0.04) and an increase in IL-2 (p = 0.008) and IL-12 (p = 0.007) mRNA expression compared to the HCs. The treated adult patients showed elevated Serine (p = 0.003) and Glycine (p = 0.04) levels, as well as increased IL-12 (p < 0.0001) mRNA expression, and a decrease in Tryptophan (p = 0.04) levels relative to the controls. Additionally, the treated adult patients had higher plasma levels of Threonine compared to both the active (p = 0.04) and control (p = 0.02) subjects, and the increased mRNA expression of IL-4 (p = 0.01) in comparison to the active patients. In active children with CD, the IL-2 mRNA level was found to be higher than in the controls (p < 0.0001) and in the treated children (p = 0.005). The treated children with CD exhibited decreased plasma levels of Tryptophan (p = 0.01) and Isoleucine (p = 0.01) relative to the controls, and the increased mRNA expression of TGFβ (p = 0.04) relative to the active patients. Elevated levels of specific AAs (Serine, Glycine, Threonine) in the treated CD patients suggested their potential to improve intestinal damage and inflammation, while decreased levels of Tryptophan and Isoleucine highlighted the need for dietary intervention.

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Section: Discussionmentioning

confidence: 48%

Investigating the Impact of Vitamin A and Amino Acids on Immune Responses in Celiac Disease Patients

Fallah,

Asri,

Nikzamir

et al. 2024

Diseases

View full text Add to dashboard Cite

show abstract

“…According to their results, 7.5% of patients revealed deficiency of vitamin A [36]. Weintraub et al in a study on active children with CD, did not observe an association between CD and vitamin A deficiency [40]. It should be noted that lower consumption of fish by our participated adults with active CD may had a negative effect on their vitamin A levels.…”

Section: Discussionmentioning

confidence: 50%

Altered Peripheral Amino Acid Profile Has Pivotal Role in Controlling Pro- and anti- Inflammatory Responses in Celiac Disease

Fallah,

Asri,

Nikzamir

et al. 2023

Preprint

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The amino acids (AAs) and vitamins imbalances are observed in celiac disease (CD). This study evaluated the plasma profile of vitamin A and AAs and the expression level of IL-2, IL-4, IL-10, IL-12 and TGFβ in CD patients. A total of 60 children and adults with CD and 40 healthy controls (HCs) were included. Plasma profile of Vitamin A and AAs and the mRNA expression levels of target genes were assessed. Active adult patients exhibited a decrease in Vitamin A levels (p=0.04) and an increase in IL-2 (p=0.008) and IL-12 (p=0.007) mRNA expression compared to HCs. Treated adult patients showed elevated Serine (p=0.003) and Glycin (p=0.04) levels, as well as increased IL-12 (P&lt;0.0001) mRNA expression, and a decrease in Tryptophan (p=0.04) levels relative to the controls. Additionally, treated adult patients had higher plasma levels of Threonine compared to both active (p=0.04) and control (p=0.02) subjects, and increased mRNA expression of IL-4 (p=0.01) in comparison to active patients. In active children with CD, IL-2 mRNA level was found to be higher than in controls (P&lt;0.0001) and in treated children (p=0.005). Treated children with CD exhibited decreased plasma levels of Tryptophan (p=0.01) and Isoleucine (p=0.01) relative to the controls, and increased mRNA expression of TGFβ (p=0.04) relative to active patients. Managing Retinoic acid levels is crucial to alleviate intestinal inflammation of CD patients. Threonine, tryptophan, and Isoleucine are potential therapeutic options for treating CD, and targeting serine, histidine, tyrosine, and aspartate may hold promise as therapeutic targets for CD patients.

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“…Most studies analyzed 25(OH)D by chemiluminescent immunoassay. Nineteen articles compared 25(OH)D levels between CD patients and control groups [8, 14, 17-20, 22, 25-28, 30-33, 35, 36, 42, 43] , of which eleven found lower 25(OH)D levels in CD patients compared with controls [17,18,20,25,28,31,33,35,36,42,43] . Eleven articles reported the numbers of patients and controls with VitD de ciency [8,14,18,22,25,26,28,30,33,35,43] , and eight showed that 25(OH)D de ciency was more prevalent in CD patients [8,18,25,26,28,33,35,43] .…”

Section: Basic Characteristicsmentioning

confidence: 99%

Relationship between Vitamin D Levels and Pediatric Celiac Disease: A Systematic Review and Meta-analysis

Sun,

Zhou,

Tian

et al. 2023

Preprint

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Background: The relationship between vitamin D (VitD) levels and pediatric celiac disease (CD) remains controversial. In this study, we conducted a systematic review and meta‐analysis to examine the relationship between VitD and pediatric CD. Methods: We screened relevant studies from PubMed, EMBASE and Web of Science published in English from January 1, 2000, to August 1, 2023. The included studies were assessed according to the STROBE checklist. Heterogeneity was quantified by Cochran’s Q test and the I2 statistic. Publication bias was estimated by Begg’s test and Egger test. Meta‐regression was used to detect potential sources of heterogeneity. Results: A total of 26 studies were included in the meta-analysis. Average 25(OH)D levels, as the main form of VitD, there was significant difference in CD patients and healthy controls (weighted mean difference (WMD) = −5.77, 95% confidence interval (CI) = [−10.86, − 0.69] nmol/L). Meanwhile, there was significant difference in the incidence of 25(OH)D deficiency between CD patients and healthy controls (odds ratio 2.20, 95% CI= [1.19, 4.08]). Ten articles reported changes in 25(OH)D levels before and after administering a GFD in patients with CD, while the result of this study revealed no change in 25(OH)D levels in CD patients after a gluten-free diet (GFD) compared to controls (WMD = −2.22, 95% CI = [−7.25, 2.81] nmol/L). Conclusions: VitD levels in pediatric CD patients were lower than healthy controls, and 25(OH)D deficiency was more prevalent in CD patients. We found no change in 25(OH)D levels in CD patients after GFD compared to controls, which inconsistent with previous research. Further well-designed, longitudinal, prospective cohort studies focusing on the role of VitD in the pathogenesis of CD are therefore needed.

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Vitamin A levels are comparable between children with newly diagnosed coeliac disease and non‐coeliac controls

Cited by 5 publications

References 17 publications

Investigating the Impact of Vitamin A and Amino Acids on Immune Responses in Celiac Disease Patients

Investigating the Impact of Vitamin A and Amino Acids on Immune Responses in Celiac Disease Patients

Altered Peripheral Amino Acid Profile Has Pivotal Role in Controlling Pro- and anti- Inflammatory Responses in Celiac Disease

Relationship between Vitamin D Levels and Pediatric Celiac Disease: A Systematic Review and Meta-analysis

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