Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties

Jenning, Volkhard; Schäfer‐Korting, Monika; Gohla, Sven

doi:10.1016/s0168-3659(99)00223-0

Cited by 458 publications

(251 citation statements)

References 7 publications

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“…Figure 3 shows the quantity of cidofovir detected, in the different strata of the skin, 24 h after topical application of microparticles (15 mg of cidofovir) and the control solution (15 mg of the drug). It has been previously reported that in the porcine skin, the upper 100 μm represented mainly the stratum corneum and upper layers of viable epidermis, between 100 to 200 μm consisted basically of viable epidermis and dermis was located from 200 to 500 μm (Jenning et al, 2000a). The distribution profiles obtained for the two formulations showed that the quantity of cidofovir retained in the skin decreased with the depth.…”

Section: Skin Penetration and Distribution Of Cidofovir-loaded Micropmentioning

confidence: 78%

Optimization of topical cidofovir penetration using microparticles

Santoyo

Jalón

Ygartua

et al. 2002

International Journal of Pharmaceutics

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Cidofovir is a new class of antiviral agent with potent in vitro and in vivo activity against a broad spectrum of herpes viruses. The aim of this work was to obtain a prolonged therapeutic effect of cidofovir in the basal epidermis after its topical application. For this purpose, PLGA microparticles were prepared by solvent evaporation and spray-drying methods. Microparticles prepared by spray-drying showed a encapsulation efficiency of 80%.Conversely, for all the microspheres prepared by the W/O/W solvent evaporation method the encapsulation efficiency was low. Also, microparticles prepared by spray-drying showed a higher burst release. Skin penetration and distribution experiments were carried out with cidofovir-loaded microparticles prepared by spray-drying, since these carriers presented the best characteristics in terms of size and encapsulation efficiency. A cidofovir solution in 0.2% PVA served for comparison. Penetration experiments were carried out in Franz type diffusion cells with an available diffusion area of 1.76 cm 2 , using porcine skin. The results obtainedshowed that the amount of cidofovir penetrated, over a 24 h time period, was higher with the drug solution than with microparticles. Cidofovir distribution in porcine skin, after topical application of microparticles and drug solution for 24 h, was determined by horizontal slicing of the skin. The profiles obtained for the two formulations showed that the quantity of cidofovir retained in the skin decreased with the depth. Besides the amount of cidofovir found in the basal epidermis (120-150 μm) was much higher with microparticles than with the control solution. These data showed that cidofovir-loaded microparticles could improve cidofovir topical therapy since these vehicles increased drug retention in the basal epidermis and decreased its penetration through the skin.

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Section: Skin Penetration and Distribution Of Cidofovir-loaded Micropmentioning

confidence: 78%

Optimization of topical cidofovir penetration using microparticles

Santoyo

Jalón

Ygartua

et al. 2002

International Journal of Pharmaceutics

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“…SLNs used for topical application for various drugsuch as anticancer [16], vitamin-A [17], isotretinoin, flurbiprofen [18].Using glyceryl behenate, vitamineA-loaded nanoparticles can be prepared. Thismethod is useful for the improvement ofpenetration with sustained release.…”

Section: Slns For Topical Usementioning

confidence: 99%

Solid Lipid Nanoparticle: A Review

Joshi¹

2012

iosrphr

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“…In general terms, SLN and NLC aqueous dispersions can be incorporated into hydrogels consisting of more or less uncharged polymers without significant changes in the particle size characteristics and j values [16]. In the case of gel-forming polymers with very polar groups, like chitosan, possible interactions between negative surface charge of lipid nanoparticles and polar groups of this polymer must be taken into account.…”

Section: Zeta Potential (J)mentioning

confidence: 99%

Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations

Souto

Wissing

Barbosa

et al. 2004

European Journal of Pharmaceutics and Biopharmaceutics

200

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Aqueous dispersions of lipid nanoparticles are being investigated as drug delivery systems for different therapeutic purposes. One of their interesting features is the possibility of topical use, for which these systems have to be incorporated into commonly used dermal carriers, such as creams or hydrogels, in order to have a proper semisolid consistency. For the present investigation four different gel-forming agents (xanthan gum, hydroxyethylcellulose 4000, Carbopol w 943 and chitosan) were selected for hydrogel preparation. Aqueous dispersions of lipid nanoparticles-solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)-made from tripalmitin were prepared by hot high pressure homogenization and then incorporated into the freshly prepared hydrogels. NLC differ from SLN due to the presence of a liquid lipid (Miglyol w 812) in the lipid matrix. Lipid nanoparticles were physically characterized before and after their incorporation into hydrogels. By means of rheological investigations it could be demonstrated that physical properties of the dispersed lipid phase have a great impact on the rheological properties of the prepared semisolid formulations. By employing an oscillation frequency sweep test, significant differences in elastic response of SLN and NLC aqueous dispersions could be observed. q

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Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties

Cited by 458 publications

References 7 publications

Optimization of topical cidofovir penetration using microparticles

Optimization of topical cidofovir penetration using microparticles

Solid Lipid Nanoparticle: A Review

Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations

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