Vitamin A status during the third trimester of pregnancy in Spanish women: influence on concentrations of vitamin A in breast milk

Ortega, Rosa M.; Andrés, Pedro; Martínez, Rosa María Goig; López‐Sobaler, A. M.

doi:10.1093/ajcn/66.3.564

Cited by 73 publications

(49 citation statements)

References 20 publications

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“…Measurements of serum vitamin A concentration and dietary intake and associating them with breast milk levels suggest a level of 30 Ag/dL below which the vitamin A status may be defined to be deficient in pregnancy 18 . A similar but arbitrary cutoff level was also suggested by Sivakumar et al 19 .…”

Section: Discussionmentioning

confidence: 99%

Effects of vitamin A deficiency during pregnancy on maternal and child health

Radhika¹

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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Objective To examine the association between biochemical vitamin A deficiency in pregnancy and maternal and fetal health. Design A cross sectional clinical study.Setting Antenatal clinic of nutrition unit of Niloufer Hospital catering for a low socio-economic population, and a private nursing home (Swapna nursing home) catering for a high socio-economic population. Population 736 pregnant women in their third trimester of pregnancy belonging to low (n ¼ 522) and high socio-economic groups (n ¼ 214). Methods All the women were subjected to a detailed clinical, anthropometric and obstetric examination. Night blindness was assessed by administering the standard WHO questionnaire. Birthweight and gestational age of the infants, maternal anaemia and development of pregnancy-induced hypertension in the mother were recorded. Haemoglobin and serum retinol were estimated at the time of recruitment to the study. Main outcome measures Serum retinol levels, anaemia, pregnancy-induced hypertension, birthweight and gestational age of the infant. Results Night blindness was observed in 2.9% of the women and subclincal vitamin A deficiency (serum retinol <20 Ag/dL with no clinical signs) in 27% of the women. Moderate to severe anaemia was observed in 41.2% of the women, and 15.8% of the women developed pregnancy-induced hypertension. Sixty-one (9.4%) women delivered preterm. Univariate analysis identified a significant association between serum retinol <20 Ag/dL and preterm delivery (OR ¼ 1.74, 95% CI 1.03 -2.96), maternal anaemia (OR ¼ 1.82, 95% CI 1.28-2.60) and pregnancy-induced hypertension (OR ¼ 1.56, 95% CI 1.02-2.83). After adjusting for the confounding variables (body mass index, parity, age and socio-economic status) in a multivariate analysis, the significant associations between serum retinol <20 Ag/dL and preterm delivery ( P ¼ 0.02) and anaemia ( P ¼ 0.003) persisted, while that for pregnancy-induced hypertension disappeared ( P ¼ 0.71). Conclusion The study suggests that subclinical vitamin A deficiency is a problem during the third trimester of pregnancy. Serum concentration of retinol <20 Ag/dL appears to indicate a deficient status, and is associated with an increased risk of preterm delivery and maternal anaemia.

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Section: Discussionmentioning

confidence: 99%

Effects of vitamin A deficiency during pregnancy on maternal and child health

Radhika¹

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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“…49 Considering that the presence of gestational diabetes aggravates the tendency to VAD development in these women, the provision of proper quantities of this vitamin for their infants will be damaged, making them vulnerable to presenting limited stock of vitamin A in the body. 4,6,34 This way, this nutritional disorder may cause an increase in mortality, morbidity and blindness in these children. It is known then that pre-school children with deficient vitamin A reserves in the body present a higher risk of death by diarrhea, respiratory infections, and chicken pox than children with adequate vitamin A state, since it has a protective role against these complications.…”

Section: Vitamin A: Deficiency and Diabetes Mellitusmentioning

confidence: 99%

Vitamina A e diabetes gestacional

Lira¹,

Dimenstein²

2010

Rev. Assoc. Med. Bras.

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“…Los valores de vitamina A obtenidos de sangre de cordón umbilical se clasificaron en intervalos según la propuesta de la OMS (16). Para el diagnóstico de hipovitaminosis A se consideró como punto de corte <1,05 mmol/L (<30 mg/dl) de acuerdo con lo sugerido por diversos autores (17)(18)(19).…”

Section: Pacientes Y Métodosunclassified

Relación Entre Los Niveles De Ácido Todo Trans-Retinoico en Sangre De Cordón Umbilical Y Medidas Antropométricas Del Recién Nacido

et al. 2007

Rev. chil. obstet. ginecol.

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RESUMENAntecedentes: La vitamina A, principalmente en su forma de ácido todo trans-retinoico, desempeña una función de vital importancia durante el desarrollo gestacional en todos los tejidos y órganos del cuerpo. Objetivo: Determinar los niveles de ácido retinoico en el suero de sangre de cordón umbilical y relacionarlos con el peso/edad gestacional del recién nacido y el consumo materno de vitamina A, conjuntamente con variables socio-económicas y nutricionales. Método: Estudio descriptivo de corte transversal, analizando un total de 62 neonatos y sus madres, provenientes de las maternidades de los Hospitales San José y Barros Luco-Trudeau, Santiago de Chile. Resultados: En la población en estudio se observó una relación directa entre el peso/edad gestacional del neonato y el consumo materno de vitamina A, pero no con los niveles de esa vitamina en el suero de sangre de cordón umbilical. Se encontró que el consumo medio de vitamina A en las embarazadas fue sólo de 2298 ± 1416,8 UI, siendo la dosis recomendada por OMS de 8000 UI. Conclusión: Existe asociación entre la ingesta de vitamina A y el estado nutricional materno en relación con el peso/edad gestacional del neonato. Debido a que los requerimientos nutricionales del feto están privilegiados por sobre los maternos, no se observaron diferencias en las características antropométricas del neonato asociadas a la ingesta materna de vitamina A.PALABRAS CLAVES: Vitamina A, ácido trans-retinoico, nutrición materna, nutrición fetal SUMMARY Background: Vitamin A, mainly in their form of retinoic acid, it carries out a function of vital importance during the gestational development, in all the tissues and organs of the body. Objective: To evaluate the levels of retinoic acid in the serum of blood from umbilical cord and to relate them with the weight/gestational age ratio of the newborns and the maternal intake of vitamin A, jointly with socioeconomic and nutritional variables. Method: A descriptive study of traverse court, in the maternities of the Hospitals San José and Barros Luco-Trudeau of Santiago, Chile, studying a total of 62 cases. Results: In the population in study, a direct relationship was observed between the newborn ratio weight/gestational age and the maternal consumption of vitamin A, but no relationship was found among the same weight/gestational age ratio and the levels of this vitamin in the serum of blood of umbilical cord. On the other hand, it was found that the

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Vitamin A status during the third trimester of pregnancy in Spanish women: influence on concentrations of vitamin A in breast milk

Cited by 73 publications

References 20 publications

Effects of vitamin A deficiency during pregnancy on maternal and child health

Effects of vitamin A deficiency during pregnancy on maternal and child health

Vitamina A e diabetes gestacional

Relación Entre Los Niveles De Ácido Todo Trans-Retinoico en Sangre De Cordón Umbilical Y Medidas Antropométricas Del Recién Nacido

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