Vitamin A Status of Steady State Sickle Cell Anaemia Patients Compared to Normal Control in Maiduguri North Eastern Nigeria

Tukur, MA; Odeh, SO; Ambe, J; Eyinkwola, O.; Salami, H.A.

doi:10.9734/bjmmr/2015/19521

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“…Studies have also shown that children with SCA have elevated metabolic rates that can result in protein-energy deficits [32] and deficiencies in micronutrients, especially zinc [33]. Antioxidant vitamins A and E were also found to be low in SCA patients compared to the normal controls [28], [29]. High resting metabolic rate of sickle anaemia patients was reported compared to their counterpart's age and sex marched control subjects with a normal haemoglobin genotype [34].…”

Section: Discussionmentioning

confidence: 99%

“…Recently increase metabolic requirement (hyper metabolism) and relative nutrient shortage found in HbSS can be accounted for by the characteristic haemolytic anaemia [26]. Low circulating level of antioxidant vitamin A and E have been reported in SCA patients [27], [28], [29]. Despite that no clinical benefit recorded for supplementing of these micronutrients.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Vitamins A and E in Relation to BMI in Steady State Sickle Cell Anaemia and Normal Controls in North Eastern Nigeria

Aminu¹

2017

SJPH

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Abstract:Sickle cell anaemia is one of the commonest causes of anaemia in sub-Saharan Africa. It causes significant morbidity and mortality, commoner in black Africa, but due to increase medical care, the life expectancy is on increase. Several studies have been carried out on sickle cell anaemia (SCA) nationally and internationally. This present study determined the BMI of SCA patients in the steady state compared to normal control in the north-eastern Nigeria. A crosssectional study was carried out at the University of Maiduguri Teaching Hospital (UMTH) as a referral center. Undergraduate students, secondary and primary school students of the University of Maiduguri Borno state were incorporated in the study as controls. A total number of 120 subjects were enrolled into the study constituting 60 subjects with homozygous SS, and 60 controls who are homozygous AA. Random sampling technique was employed in the selection of the subjects that attends the sickle cell haematology clinics both in adults and paediatrics that were at their steady state. BMI of the SCA were found to be either normal weight (18.5-24.9kg/m 2 ) or underweight (<18.5kg/m 2 ), while the subject with normal haemoglobin genotype showed overweight (25-29.9kg/m 2 ) and obese (>29.9kg/m 2 ) in addition to underweight and normal weight. Antioxidant vitamins A and E were also found to be low in SCA patients compared to the normal controls In conclusion, we therefore concluded that overweight and obese is very rare in patients with sickle cell anaemia.

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