Vitamin A Supplementation in Extremely Low-Birth-Weight Infants: Subgroup Analysis in Small-for-Gestational-Age Infants

Nolen, Tracy L.; Das, Abhik; Higgins, Rosemary D.; Tyson, Jon E.; Oh, William; Devaskar, Sherin U.; Londhe, Vedang A.

doi:10.1055/s-0032-1333410

Cited by 19 publications

(4 citation statements)

References 18 publications

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“…Despite the high prevalence of BPD, no effective therapeutics were available to treat this disease in the past twenty years. Only vitamin A, caffeine, and corticosteroid are clinically used after birth for BPD intervention [123][124][125][126]. Recently, research on the epigenetic involvement in BPD has been steadily increasing.…”

Section: Perspectives For Treatment and Prevention Of Neonatal Chronic Lung Diseasementioning

confidence: 99%

Intrauterine Hypoxia and Epigenetic Programming in Lung Development and Disease

et al. 2021

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Clinically, intrauterine hypoxia is the foremost cause of perinatal morbidity and developmental plasticity in the fetus and newborn infant. Under hypoxia, deviations occur in the lung cell epigenome. Epigenetic mechanisms (e.g., DNA methylation, histone modification, and miRNA expression) control phenotypic programming and are associated with physiological responses and the risk of developmental disorders, such as bronchopulmonary dysplasia. This developmental disorder is the most frequent chronic pulmonary complication in preterm labor. The pathogenesis of this disease involves many factors, including aberrant oxygen conditions and mechanical ventilation-mediated lung injury, infection/inflammation, and epigenetic/genetic risk factors. This review is focused on various aspects related to intrauterine hypoxia and epigenetic programming in lung development and disease, summarizes our current knowledge of hypoxia-induced epigenetic programming and discusses potential therapeutic interventions for lung disease.

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Section: Perspectives For Treatment and Prevention Of Neonatal Chronic Lung Diseasementioning

confidence: 99%

Intrauterine Hypoxia and Epigenetic Programming in Lung Development and Disease

et al. 2021

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“…Despite the high prevalence of BPD, no new drugs have been approved for the management of this disease over the past two decades. To date, among the many tried interventions, postnatal use of vitamin A 52 , 53 , caffeine 54 , and corticosteroids 55 are the only interventions that have led to a decrease in the rate of BPD. The use of vitamin C in pregnant smokers has been shown to improve pulmonary function tests in newborns at birth and 3 months of age with decreased wheezing up to 1 year of age 56 , 57 .…”

Section: New and Upcoming Therapies In The Management And Prevention mentioning

confidence: 99%

Recent advances in understanding and management of bronchopulmonary dysplasia

Sahni

Bhandari

2020

F1000Res

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In the current era, the survival of extremely low-birth-weight infants has increased considerably because of new advances in technology; however, these infants often develop chronic dysfunction of the lung, which is called bronchopulmonary dysplasia (BPD). BPD remains an important cause of neonatal mortality and morbidity despite newer and gentler modes of ventilation. BPD results from the exposure of immature lungs to various antenatal and postnatal factors that lead to an impairment in lung development and aberrant growth of lung parenchyma and vasculature. However, we still struggle with a uniform definition for BPD that can help predict various short- and long-term pulmonary outcomes. With new research, our understanding of the pathobiology of this disease has evolved, and many new mechanisms of lung injury and repair are now known. By utilizing the novel ‘omic’ approaches in BPD, we have now identified various factors in the disease process that may act as novel therapeutic targets in the future. New investigational agents being explored for the management and prevention of BPD include mesenchymal stem cell therapy and insulin-like growth factor 1. Despite this, many questions remain unanswered and require further research to improve the outcomes of premature infants with BPD.

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“…Vitamin A: important for lung function; vitamin A deficiency during mechanical ventilation may be relatively more damaging to the preterm infant’s lungs, although results appear to be mixed (39).…”

Section: Wg 1: Nutrient Specificationsmentioning

confidence: 99%

“…Antioxidant and pro-oxidant nutrients have been evaluated in the development of BPD. One antioxidant example is vitamin A, which has been the focus of several studies in relation to lung development (39, 141–144). Inositol’s effect on pulmonary surfactant development and the incidence of BPD has been reviewed (145).…”

Section: Wg 3: Gastrointestinal and Surgical Issuesmentioning

confidence: 99%

Working group reports: evaluation of the evidence to support practice guidelines for nutritional care of preterm infants—the Pre-B Project

Raiten¹,

Steiber

Carlson

et al. 2016

The American Journal of Clinical Nutrition

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The "Evaluation of the Evidence to Support Practice Guidelines for the Nutritional Care of Preterm Infants: The Pre-B Project" is the first phase in a process to present the current state of knowledge and to support the development of evidence-informed guidance for the nutritional care of preterm and high-risk newborn infants. The future systematic reviews that will ultimately provide the underpinning for guideline development will be conducted by the Academy of Nutrition and Dietetics' Evidence Analysis Library (EAL). To accomplish the objectives of this first phase, the Pre-B Project organizers established 4 working groups (WGs) to address the following themes: 1) nutrient specifications for preterm infants, 2) clinical and practical issues in enteral feeding of preterm infants, 3) gastrointestinal and surgical issues, and 4) current standards of infant feeding. Each WG was asked to 1) develop a series of topics relevant to their respective themes, 2) identify questions for which there is sufficient evidence to support a systematic review process conducted by the EAL, and 3) develop a research agenda to address priority gaps in our understanding of the role of nutrition in health and development of preterm/neonatal intensive care unit infants. This article is a summary of the reports from the 4 Pre-B WGs.

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Vitamin A Supplementation in Extremely Low-Birth-Weight Infants: Subgroup Analysis in Small-for-Gestational-Age Infants

Cited by 19 publications

References 18 publications

Intrauterine Hypoxia and Epigenetic Programming in Lung Development and Disease

Intrauterine Hypoxia and Epigenetic Programming in Lung Development and Disease

Recent advances in understanding and management of bronchopulmonary dysplasia

Working group reports: evaluation of the evidence to support practice guidelines for nutritional care of preterm infants—the Pre-B Project

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