Vitamin B and vitamin D as modulators of gut microbiota in overweight individuals

Jiang, Shangfei; Zhu, Qiwei; Mai, Mingxiao; Yang, Wen‐Yi; Du, Guankui

doi:10.1080/09637486.2020.1748580

Cited by 15 publications

(21 citation statements)

References 46 publications

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“…After eliminating the duplicates, we found 955 publications, of which 30 were assessed for eligibility. After the revisions of the selected full-text articles, a further 5 were excluded because they lacked adequate data on VD supplementation or showed the analysis of vaginal microbiota as an outcome [14,[23][24][25][26]. As a result, this review covers 25 studies.…”

Section: Resultsmentioning

confidence: 99%

The Association between Vitamin D and Gut Microbiota: A Systematic Review of Human Studies

et al. 2021

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Recent evidence has shown a number of extra-skeletal functions of Vitamin D (VD), primarily involving the immune system. One of these functions is mediated by the modulation of gut microbiota, whose alterations are linked to many diseases. Our purpose is to contribute to the understanding of existing evidence on the association between VD and gastrointestinal microbiota alterations. A systematic review of studies with human subjects has been conducted up to January 2021. We included publications reporting the association between gut microbiota and VD, including VD supplementation, dietary VD intake and/or level of 25(OH)D. We identified 25 studies: 14 were interventional and 11, observational. VD supplementation was found to be associated with a significant change in microbiome composition, in particular of Firmicutes, Actinobacteria and Bacteroidetes phyla. Furthermore, Firmicutes were found to be correlated with serum VD. Concerning alpha and beta diversity, a high nutritional intake of VD seems to induce a shift in bacterial composition and/or affects the species’ richness. Veillonellaceae and Oscillospiraceae families, in the Firmicutes phylum, more frequently decreased with both increasing levels of 25(OH)D and vitamin D supplementation. We found evidence of an association, even though the studies are substantially heterogeneous and have some limitations, resulting sometimes in conflicting results. To further understand the role of VD on the modulation of the gastrointestinal microbiota, future research should be geared toward well-designed animal-based studies or larger randomized controlled trials (RCTs).

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Section: Resultsmentioning

confidence: 99%

The Association between Vitamin D and Gut Microbiota: A Systematic Review of Human Studies

et al. 2021

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“…Data from the American Gut Project were used to assess the impact of vitamin B and/or D supplementation on the GM in groups of people with normal weight (NW) or overweight (OW). 83 Despite no significant impact on alpha-diversity indexes in all groups, the vitamin supplementation alone had almost no effect in NW group but had beneficial impact in OW. Noteworthy, vitamin B supplementation induced a significant decrease in Tenericutes at the phylum level and several groups at the family level (Mogibacteriaceae, Porphyromonadaceae, Coriobacteriaceae, and Comamonadaceae).…”

Section: Effect Of Vitamin Supplementation On Gmmentioning

confidence: 87%

“…88,89 Vitamin supplements, and in particular vitamin D, also had an important impact on the functionality of the GM. 83 In NW groups, there was a decrease in genes implicated in amino-acids biosynthesis patients. 83 In a murine study of C57BL/6J weaning male, the effect of vitamin A supplementation in condition of standard (CD) or high-fat highsugar diet (HFSD) was studied.…”

Section: Effect Of Vitamin Supplementation On Gmmentioning

confidence: 98%

Gut microbiota and vitamin status in persons with obesity: A key interplay

et al. 2021

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There are numerous factors involved in obesity progression and maintenance including systemic low-grade inflammation, adipose tissue dysfunction, or gut microbiota dysbiosis. Recently, a growing interest has arisen for vitamins' role in obesity and related disorders, both at the host and gut bacterial level. Indeed, vitamins are provided mostly by food, but some, from the B and K groups in particular, can be synthesized by the gut bacterial ecosystem and absorbed in the colon. Knowing that vitamin deficiency can alter many important cellular functions and lead to serious health issues, it is important to carefully monitor the vitamin status of patients with obesity and potentially already existing comorbidities as well as to examine the dysbiotic gut microbiota and thus potentially altered bacterial metabolism of vitamins. In this review, we examined both murine and human studies, to assess the prevalence of sub-optimal levels of several vitamins in obesity and metabolic alterations. This review also examines the relationship between vitamins and the gut microbiota in terms of vitamin production and the modulation of the gut bacterial ecosystem in conditions of vitamin shortage or supplementation. Furthermore, some strategies to improve vitamin status of patients with severe obesity are proposed within this review.

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“…Gut microbiota have been reported to play a role in systemic chronic inflammation, which has been established as a key factor for cardiovascular risk (Salvucci 2019). Milk and dairy components (including vitamin D) have been taken into account for potentially modulating gut microbiota (Jiang et al 2020).…”

Section: Editorialmentioning

confidence: 99%

Are there any concerns about dairy food consumption and cardiovascular health?

Grosso

2021

International Journal of Food Sciences and Nutrition

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Vitamin B and vitamin D as modulators of gut microbiota in overweight individuals

Cited by 15 publications

References 46 publications

The Association between Vitamin D and Gut Microbiota: A Systematic Review of Human Studies

The Association between Vitamin D and Gut Microbiota: A Systematic Review of Human Studies

Gut microbiota and vitamin status in persons with obesity: A key interplay

Are there any concerns about dairy food consumption and cardiovascular health?

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