Vitamin B for treating peripheral neuropathy

Ang, CD; Alviar, MJM; Bautista, GGP; Bautista, MR; Chua, JV; Co, HU; Dans, AL; Roxas, AA; Jj, Tan; Villarruz, MVC

doi:10.1002/14651858.cd004573.pub2

Cited by 17 publications

(20 citation statements)

References 6 publications

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“…The authors concluded that more high‐quality, double‐blind randomized controlled trials are needed to confirm the effects of vitamin B 12 on diabetic neuropathy. Despite some evidence of benefits associated with vitamin B in the treatment of neuropathies of other origins, 47 currently, supplementing the diet with B vitamins cannot be recommended as a standard or routine preventive or therapeutic option for individuals with diabetic neuropathy.…”

Section: B‐complex Vitaminsmentioning

confidence: 99%

Role of vitamins and minerals in prevention and management of type 2 diabetes mellitus

2010

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Vitamins and minerals play an important role in glucose metabolism, so understanding the impact of vitamin and mineral deficiencies and the potential utility of supplementation is relevant to the prevention and/or management of type 2 diabetes mellitus (DM). This review investigates current evidence for relationships between selected nutrients - vitamin B complex, antioxidants (vitamin A, C, E and carotenoids), calcium, vitamin D, vitamin K, magnesium, sodium, and potassium - and glucose metabolism. The investigation reveals current evidence is not strong enough for supplementation with minerals and vitamins to be recommended on a large scale for the prevention or management of DM. In order to prevent deficiencies and maintain health, the majority of diabetic individuals should receive daily vitamins and minerals within the ranges of recommended values from consumption of natural food sources and/or fortified foods. Further studies including large samples and longer follow-up periods are necessary to ascertain the benefits of mineral and vitamin supplementation to subsets of individuals who are at increased risk for DM or its complications.

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Section: B‐complex Vitaminsmentioning

confidence: 99%

Role of vitamins and minerals in prevention and management of type 2 diabetes mellitus

2010

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“…1 It has been used for decades for the treatment of several disorders such as neurological, diabetic and cardiovascular complications. [2][3][4][5][6] Thiamine exists mainly as its diphosphated metabolite (i.e. thiamine diphosphate, TDP) in addition to small amounts of free thiamine, thiamine monophosphate (TMP), and thiamine triphosphate (TTP).…”

mentioning

confidence: 99%

Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride

Xie

Zhang

et al. 2014

The Journal of Clinical Pharma

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Benfotiamine is a lipid-soluble thiamine precursor which can transform to thiamine in vivo and subsequently be metabolized to thiamine monophosphate (TMP) and thiamine diphosphate (TDP). This study investigated the pharmacokinetic profiles of thiamine and its phosphorylated metabolites after single- and multiple-dose administration of benfotiamine in healthy Chinese volunteers, and assessed the bioavailability of orally benfotiamine administration compared to thiamine hydrochloride. In addition, concentration of hippuric acid in urine which is produced in the transformation process of benfotiamine was determined. The results showed that thiamine and its phosphorylated metabolites exhibited different pharmacokinetic characteristics in plasma, blood and erythrocyte, and one-compartment model provided the best fit for pharmacokinetic profiles of thiamine. The transformation process of benfotiamine to thiamine produced large amount of hippuric acid. No accumulation of hippuric acid was observed after multiple-dose of benfotiamine. Compared to thiamine hydrochloride, the bioavailability of thiamine in plasma and TDP in erythrocyte after oral administration of benfotiamine were 1147.3 ± 490.3% and 195.8 ± 33.8%, respectively. The absorption rate and extent of benfotiamine systemic availability of thiamine were significantly increased indicating higher bioavailability of thiamine from oral dose of benfotiamine compared to oral dose of thiamine hydrochloride.

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“…On the other hand, vitamin B complex plays an important role in the treatment of diabetic neuropathy in many ways. Thus, it has been found that Vitamin B complex can reduce high levels of homocysteine in the blood (levels associated with the degree of diabetic neuropathy), but it also plays an essential role in repairing and regeneration of peripheral tissues [29][30][31][32][33].…”

Section: Resultsmentioning

confidence: 99%

Thioctic Acid and Vitamin B Complex Improves Clinical Sings in Diabetic Peripheral Neuropathy

Rotaru¹,

Albu²,

Tudoraşcu³

et al. 2019

Rev. Chim.

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Diabetic neuropathy is the most common cause of neuropathy worldwide and it is estimated to affect about half of people with diabetes. The goal of our study is to compare the effectiveness of thioctic acid treatment alone versus the efficacy of thioctic acid plus vitamin B complex in patients with diabetic peripheral polyneuropathy (DPN). We conducted a prospective, observational study staring from October 2017 to December 2018, in which we included 56 DPN patients. Depending on the Michigan neuropathic screening instrument (MNSI) we divided the patients into two subgroups: patients with MNSI [7 and patients whose MNSI did not decrease sufficiently during the therapeutic protocol. 36 patients (64.2%) of the total patients enrolled in the study had an MNSI [7 at one of the follow-up meetings. These patients were also divided according to the therapeutic protocol applied in a group of patients who were treated with only thioctic acid (TA group) and in a group of patients who were treated with thioctic acid plus vitamin B complex (TA + B group). We noticed a greater proportion of patients who had a MNSI [7 in the TA + B group. This study revealed that the treatment of peripheral diabetic neuropathy with thioctic acid plus Vitamin B complex compared to thioctic acid alone was superior in terms of improving clinical features.

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Vitamin B for treating peripheral neuropathy

Cited by 17 publications

References 6 publications

Role of vitamins and minerals in prevention and management of type 2 diabetes mellitus

Role of vitamins and minerals in prevention and management of type 2 diabetes mellitus

Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride

Thioctic Acid and Vitamin B Complex Improves Clinical Sings in Diabetic Peripheral Neuropathy

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