Vitamin B for treating peripheral neuropathy

Ang, CD; Alviar, MJM; Bautista, GGP; Bautista, MRM; Dans, AL; Roxas, AA; Jj, Tan; Villaruz, MVCV

doi:10.1002/14651858.cd004573

Cited by 11 publications

(18 citation statements)

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“…A follow‐up, 12‐week, randomized, double‐blind, controlled trial evaluating the utility of vitamin B complex for the treatment of ALN produced similar results 32. A recent Cochrane database review of 13 studies (741 patients), 2 of which were specifically of ALN, found only limited data that vitamin B is effective for treating peripheral neuropathy and concluded that the evidence is insufficient to determine whether vitamin B is beneficial or harmful 4. The Woelk et al study31 was included in this review, but the Peters et al study32 was not, as the review only included studies up to 2005.…”

Section: The Thiamine Storymentioning

confidence: 91%

“…The Woelk et al study31 was included in this review, but the Peters et al study32 was not, as the review only included studies up to 2005. The pooled data indicate that vitamin B may be less efficacious than alpha‐lipoic acid, cilotazol, or cytidine triphosphate in short‐term improvement of clinical and nerve conduction study outcomes 4…”

Section: The Thiamine Storymentioning

confidence: 99%

“…The similar clinical, electrophysiological, and histopathological features of ALN compared with beriberi led to the hypothesis that ALN and beriberi were the same disease and that both were caused by thiamine deficiency 3. Despite these similarities, decades of clinical research have failed to definitively demonstrate that thiamine deficiency is the primary etiologic factor that causes ALN, or that its repletion serves as an effective treatment for ALN 4…”

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confidence: 99%

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Alcohol‐related peripheral neuropathy: Nutritional, toxic, or both?

2011

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Alcohol-related peripheral neuropathy (ALN) is a potentially debilitating complication of alcoholism that results in sensory, motor, and autonomic dysfunction. Unfortunately, ALN is rarely discussed as a specific disease entity in textbooks because it is widely assumed to primarily reflect consequences of nutritional deficiency. This hypothesis is largely based on observations first made over eight decades ago when it was demonstrated that thiamine deficiency (beriberi) neuropathy was clinically similar to ALN. In recent studies, failure of thiamine treatment to reverse ALN, together with new information demonstrating clinical and electrophysiological distinctions between ALN and nutritional deficiency neuropathies, suggests that alcohol itself may significantly predispose and enhance development of neuropathy in the appropriate clinical setting. We reviewed the evidence on both sides and conclude that ALN should be regarded as a toxic rather than nutritional neuropathy.

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Section: The Thiamine Storymentioning

confidence: 91%

Section: The Thiamine Storymentioning

confidence: 99%

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confidence: 99%

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Alcohol‐related peripheral neuropathy: Nutritional, toxic, or both?

2011

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“…However, their effectiveness has not been proven via controlled studies. The use of vitamin B supplements to treat neuropathy is also very common but also without rigorous clinical evaluation [22]. …”

Section: Introductionmentioning

confidence: 99%

Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture

Rostock

Jaroslawski

Güthlin

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Purpose. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting side effect of cytostatic drugs. Since there are no proven therapeutic procedures against CIPN, we were interested to define the role of electroacupuncture (EA) from which preliminary data showed promising results. Methods. In a randomized trial with a group sequential adaptive design in patients with CIPN, we compared EA (LV3, SP9, GB41, GB34, LI4, LI11, SI3, and HT3; n = 14) with hydroelectric baths (HB, n = 14), vitamin B1/B6 capsules (300/300 mg daily; VitB, n = 15), and placebo capsules (n = 17). The statistical power in this trial was primarily calculated for proving EA only, so results of HB and VitB are pilot data. Results. CIPN complaints improved by 0.8 ± 1.2 (EA), 1.7 ± 1.7 (HB), 1.6 ± 2.0 (VitB), and 1.3 ± 1.3 points (placebo) on a 10-point numeric rating scale without significant difference between treatment groups or placebo. In addition no significant differences in sensory nerve conduction studies or quality of life (EORTC QLQ-C30) were found. Conclusions. The used EA concept, HB, and VitB were not superior to placebo. Since, contrary to our results, studies with different acupuncture concepts showed a positive effect on CIPN, the effect of acupuncture on CIPN remains unclear. Further randomized, placebo controlled studies seem necessary. This trial is registered with DRKS00004448.

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“…Thiamine, the vitamin B1 (Figure A), is a water‐soluble vitamin that plays an essential role in cellular energy metabolism . It has been used for decades for the treatment of several disorders such as neurological, diabetic and cardiovascular complications . Thiamine exists mainly as its diphosphated metabolite (i.e.…”

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confidence: 99%

Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride

Xie

Zhang

et al. 2014

The Journal of Clinical Pharma

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Benfotiamine is a lipid-soluble thiamine precursor which can transform to thiamine in vivo and subsequently be metabolized to thiamine monophosphate (TMP) and thiamine diphosphate (TDP). This study investigated the pharmacokinetic profiles of thiamine and its phosphorylated metabolites after single- and multiple-dose administration of benfotiamine in healthy Chinese volunteers, and assessed the bioavailability of orally benfotiamine administration compared to thiamine hydrochloride. In addition, concentration of hippuric acid in urine which is produced in the transformation process of benfotiamine was determined. The results showed that thiamine and its phosphorylated metabolites exhibited different pharmacokinetic characteristics in plasma, blood and erythrocyte, and one-compartment model provided the best fit for pharmacokinetic profiles of thiamine. The transformation process of benfotiamine to thiamine produced large amount of hippuric acid. No accumulation of hippuric acid was observed after multiple-dose of benfotiamine. Compared to thiamine hydrochloride, the bioavailability of thiamine in plasma and TDP in erythrocyte after oral administration of benfotiamine were 1147.3 ± 490.3% and 195.8 ± 33.8%, respectively. The absorption rate and extent of benfotiamine systemic availability of thiamine were significantly increased indicating higher bioavailability of thiamine from oral dose of benfotiamine compared to oral dose of thiamine hydrochloride.

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Vitamin B for treating peripheral neuropathy

Cited by 11 publications

References 0 publications

Alcohol‐related peripheral neuropathy: Nutritional, toxic, or both?

Alcohol‐related peripheral neuropathy: Nutritional, toxic, or both?

Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture

Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride

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