Vitamin B&lt;sub&gt;12&lt;/sub&gt; Status in Mentally Disturbed Elderly Patients

Buxton, P K; Davison, Wilburt C.; Hyams, D. E.; Irvine, W. J.

doi:10.1159/000245212

Cited by 8 publications

(5 citation statements)

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“…The logic was simple: if clinicians were so diagnostically inexact, and vitamin B 12 deficiency were even an uncommon cause of reversible psychiatric symptoms, then our chronic mental health institutions must have many patients with vitamin B 12 deficiency‐induced psychiatric states that could be reversed if appropriately treated. A review of the literature 40,62–70 regarding the results of these inquiries is informative.…”

Section: Specific Psychiatric Conditions That Were Noted To Improvementioning

confidence: 99%

“…Their psychiatric diagnoses or course with therapy were not discussed. Forty elderly patients with a diagnosis of confusional state, dementia, or affective disorders were investigated by Buxton et al 67 in 1969 with regard to their serum vitamin B 12 levels. One patient with pernicious anemia was identified, but treatment realized no improvement in their mental status.…”

Section: Specific Psychiatric Conditions That Were Noted To Improvementioning

confidence: 99%

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What are the Psychiatric Manifestations of Vitamin B₁₂ Deficiency?

Hector¹,

Burton²

1988

J American Geriatrics Society

149

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Psychiatric symptoms attributable to vitamin B12 deficiency have been described for decades. The earlier reports are for the most part in accord with more recent ones, despite being diagnostically less specific in psychiatric and hematologic terms. These symptoms seem to fall into several clinically separate categories: slow cerebration; confusion; memory changes; delirium, with or without hallucinations and/or delusions; depression; acute psychotic states; and (more rarely) reversible manic and schizophreniform states. While there still remain abundant hematologic, psychiatric, neurologic, or nutritional reasons for obtaining a serum vitamin B12 level, its use in the investigation of the etiology of a patient's dementia seems unjustified. However, acute or subacute changes in a demented patient's mental status, specifically a clouding of their consciousness, may make such testing advisable as part of the complete workup of their delirium regardless of a normal hematologic picture.

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Section: Specific Psychiatric Conditions That Were Noted To Improvementioning

confidence: 99%

Section: Specific Psychiatric Conditions That Were Noted To Improvementioning

confidence: 99%

What are the Psychiatric Manifestations of Vitamin B₁₂ Deficiency?

Hector¹,

Burton²

1988

J American Geriatrics Society

149

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“…Depression is a common occurrence in elderly patients with pernicious anemia, and it may even be the presenting symptoms (37b). Pernicious anemia is invariably associated with dementia or a fluctuating confusional state and is more likely to be misdiagnosed as presenile or senile dementia than as depression (37c, 37d).…”

Section: Diseases Which May Present With Depression or Be Accompaniementioning

confidence: 99%

Depression in the Elderly. I. Relationship between Depression, Psychologic Defense Mechanisms and Physical Illness*

Salzman

Shader

1978

J American Geriatrics Society

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Diagnosis of depression in the elderly is sometimes difficult owing to the presence of ego defensive mechanisms or somatic symptoms that can disguise the affect. Depression also may precede, or be associated with a variety of medical illnesses which are common among older persons. Specific ego defenses and representative medical illnesses are discussed. The concepts of a depressive equivalent and pseudodementia, which particularly act to disguise the depression, are reviewed in detail.

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“…Estimates of the prevalence of subnormal serum B12 levels in patients admitted to a mental hospital have been made by many workers (Edwin et al, 1965;Hansen et al, 1966;Hutner et al, 1967;Shulman, 1967a;Buxton et al, 1969;Murphy et al, 1969). These estimates vary from 0-02% to the high level of 15.40/,,, but no valid comparison has been made between subjects admitted to hospital and subjects in the community from which they have come.…”

Section: Introductionmentioning

confidence: 99%

Clinical Trial of the Effect of Vitamin B12 in Elderly Subjects with Low Serum B12 Levels

Hughes¹,

Elwood²,

Shinton³

et al. 1970

BMJ

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Summary: A clinical trial of the effect of vitamin B12 therapy was conducted in 39 elderly subjects who had been found, in a community screening survey, to have low levels of serum B12 without a macrocytic anaemia or neuropathy. The study produced no evidence which suggests that in such subjects B12 is superior to placebo in effecting an improvement in psychiatric state or general well-being. There was a clear tendency for all the subjects to show an improvement during the trial, but this probably represents the therapeutic effect of involvement in a research exercise of this kind.

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Vitamin B<sub>12</sub> Status in Mentally Disturbed Elderly Patients

Cited by 8 publications

References 1 publication

What are the Psychiatric Manifestations of Vitamin B₁₂ Deficiency?

What are the Psychiatric Manifestations of Vitamin B₁₂ Deficiency?

Depression in the Elderly. I. Relationship between Depression, Psychologic Defense Mechanisms and Physical Illness*

Clinical Trial of the Effect of Vitamin B12 in Elderly Subjects with Low Serum B12 Levels

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Vitamin B<sub>12</sub> Status in Mentally Disturbed Elderly Patients

Cited by 8 publications

References 1 publication

What are the Psychiatric Manifestations of Vitamin B12 Deficiency?

What are the Psychiatric Manifestations of Vitamin B12 Deficiency?

Depression in the Elderly. I. Relationship between Depression, Psychologic Defense Mechanisms and Physical Illness*

Clinical Trial of the Effect of Vitamin B12 in Elderly Subjects with Low Serum B12 Levels

Contact Info

Product

Resources

About

What are the Psychiatric Manifestations of Vitamin B₁₂ Deficiency?

What are the Psychiatric Manifestations of Vitamin B₁₂ Deficiency?