Vitamin B status and response to replacement therapy in patients with burning mouth syndrome

Kurita

Psychiatry Clin Neurosci

et al. 2002

The aim of the present study was to examine pain threshold and pain recovery in patients with burning mouth syndrome (BMS) and matched no-pain controls. Twenty female patients diagnosed with BMS without organic gross changes were enrolled in the study. Twenty control subjects were chosen from age-matched healthy female volunteers. We compared the thermal pain threshold using heat beam dolorimeter on the finger and tongue between patients and controls. Warm (at 50°C for 5 s), cold (at 0°C for 30 s) and mechanical (stimulation by electric tooth brush for 15 s) stimulation was applied to the tongue for both groups. Participants were asked to rate the subjective pain using a visual analogue scale (VAS). Although there was no significant differences between patients and controls in terms of the threshold on the finger, the threshold on the tongue was significantly higher in patients than in controls. We suggest there were peripheral dysfunction at the tongue, and/or central dysfunction in patients with BMS. Among the three types of stimulation, the patients perceived significantly the highest pain from the mechanical stimulation for the first 5 min after the stimulation. Furthermore, when patients with BMS perceived some pain, they continued to complain of the pain longer and more intricately than the controls. This indicates that the pain of the patients is strongly affected not only at a sensory component but also at an affective/motivational component than the controls. However, we should be cautious of simply advancing psychogenic theory in this etiology.

Section: Introductionmentioning

confidence: 99%

Pain threshold and pain recovery after experimental stimulation in patients with burning mouth syndrome

Kurita

Psychiatry Clin Neurosci

et al. 2002

Med Buccale Chir Buccale

“…Reports looking at the role of vitB6 are in fact limited to two studies [9] and [10], and some anecdotal reports [11]. Interestingly, these two studies showed contradictory results.…”

Section: Discussionmentioning

confidence: 99%

“…However, a proper control for assessment of a placebo effect was missing in their investigation. The study carried out by Hugoson A. et al [10] was intended to control this flaw and used a placebo control to explore possible involvement of vitamin B1, B2 and B6 deficiency in the development of BMS. Besides the absence of efficacy of proper vitamin replacement therapy in patients suffering a vitB1 and B2 deficiency, no vitB6 deficiency was found in their samples.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Role of vitamin B6 in idiopathic burning mouth syndrome: some clinical observations

Dieb

Moreau

Rochefort

et al. 2016

-Introduction:Idiopathic burning mouth syndrome (iBMS) is a chronic oral pain syndrome mainly characterized by a burning sensation in the oral mucosa and an etiopathogenesis that remains unclear, with therapeutic options that are disappointing. Any clinical observation providing insight into the disorder can therefore be of interest. Among metabolic factors, deficiencies of vitamins have been pointed out, but only a few studies have focused on the role of vitamin B6 (vitB6) in this syndrome. In this report, we aimed to highlight the involvement of increased but not decreased vitB6 serum levels in a subgroup of BMS Patients. Patients and Methods: Medical files of patients who attended the chronic orofacial pain consultation, in the dental departement of the Groupe Hospitalier Pitié-Salpêtrière (GHPS) in Paris (France) between 09/03/2008 and 12/19/2015 were retrieved from the hospital database and analyzed. This retrospective study was approved by the board of the dental department and authorization for use of patient data was obtained from the National Personal Data Protection Committee (Commission Nationale de l'Informatique et des Libertés (CNIL)) (#1913570). Results: Seven per-or postmenopausal female patients out of 42 diagnosed with iBMS (17%) displayed an increase in their serum levels of vitB6, one to six times the upper normal limits. There was a statistically significant correlation between pain and vitB6 levels. Moreover, in two patients, the reversal of vitB6 levels to normal values resulted in significant decreases in pain severity. Conclusion: These clinical observations report for the first time a potential implication of elevated vitB6 serum levels in the burning sensation which might be specific to a subgroup of iBMS patients. (# 1913570) pour l'utilisation des données des patients. Résultats : Parmi les 42 patients diagnostiqués iBMS, sept (17%) présentaient des taux sériques de vitB6 sérique plus élevés, jusqu'à 6 fois les valeurs normales. Une corrélation statistiquement significative entre la douleur, évaluée par une échelle numérique simple, et les niveaux vitB6 a été observée. En outre, chez deux patients, le retour à des valeurs normales des taux sériques de vitB6 a donné lieu à une diminution significative de l'intensité douloureuse. Conclusion : Ces observations cliniques rapportent pour la première fois l'implication potentielle de taux sériques élevés de vitB6 dans les sensations de brûlure buccale qui pourraient être spécifiques d'un sous groupe de patients stomatodyniques. Résumé Key words: pyridoxine / pyridoxal 5'-phosphate (PLP) / painMed Buccale Chir Buccale 2017;23:77-83

“…Além disso, alguns estudos sugerem que a SAB está associada a baixos níveis séricos de ferro e zinco (Lamey et al, 1996;Thorstensson, 1991 (Scala et al, 2003).…”

Section: Associação De Fatores Clínicos Na Sabunclassified

Ação do tratamento homeopático na sintomatologia da síndrome da ardência bucal em duas fases: estudo duplo cego placebo controlado e estudo aberto

Chebel¹,

Silveira²

DEDICATÓRIAPrimeiramente a Deus, a Luz que emana no Universo e nos mantém vivos, repletos de energia Vital. A energia que mantém tudo em equilíbrio. A luz que ilumina todas as formas de conhecimento, de amor e solidariedade. A luz da cura e da graça. Gratidão profunda por minha vida. Aos meus pais (in memoriam), Benedictus e Anita, pelo amor incondicional devotado à família. Pelas palavras de conforto e força, quando estava triste. Por me ensinarem a nunca desistir de um sonho e de sempre buscar a felicidade, respeitando o livre arbítrio do próximo. Ser livre, com responsabilidade, esse foi o maior presente que eles me proporcionaram. Gratidão por tudo.Aos meus queridos irmãos, Sueli e Reinaldo. Meus eternos cúmplices na arte de viver. Ao meu amado sobrinho Reinaldo Junior, filho do coração. Aos meus cunhados Aldo e Aidamar, meus irmãos por escolha.Ao meu querido e amado esposo, Sergio C. Chebel, pelo companheirismo, compreensão, paciência e incentivo constantes. Minha alma gêmea. Eu te amo.Aos meus filhos do coração, Ramiro, Renato e Fabiana que preencheram a minha vida com muitas bênçãos; e principalmente, replicaram essas graças com os netos: Ana Clara, Amanda e Pedro. Beijos.A todos os meus familiares que sempre estiveram presentes nos momentos difíceis e felizes de minha vida.Aos meus queridos pacientes, que acreditaram em mim incondicionalmente.Gratidão a Todos. Em especial e com muito carinho, à Iracema Mascarenhas Pires (Nina), pela atenção, amizade e carinho que sempre demonstrou sempre pronta a me ajudar. Á Dra. Anali Gerevini Marques, farmacêutica responsável pela randomização e manipulação dos medicamentos homeopáticos e à farmácia L'officine. AGRADECIMENTOSAo Prof. Alessandro De Ana do IPEN pela realização da análise estatística A todos os meus colegas do Programa de pós-graduação, sucesso a todos! Tocando Em FrenteAndo devagar porque já tive pressa, E levo esse sorriso, porque já chorei demais, Hoje me sinto mais forte, mais feliz quem sabe, Só levo a certeza de que muito pouco eu sei, ou nada sei. Conhecer as manhas e as manhãs, O sabor das massas e das maçãs.É preciso amor pra poder pulsar, é preciso paz Pra poder sorrir, é preciso a chuva para florir.Penso que cumprir a vida, seja simplesmente Compreender a marcha, ir tocando em frente, Como um velho boiadeiro, levando a boiada Eu vou tocando os dias pela longa estrada, eu vou, Estrada eu sou. Conhecer as manhas e as manhãs, O sabor das massas e das maçãs, É preciso amor pra poder pulsar, é preciso paz Pra poder sorrir, é preciso a chuva para florir.Todo mundo ama um dia, todo mundo chora, Um dia a gente chega, no outro vai embora.Cada um de nós compõe a sua história, cada ser em si Carrega o dom de ser capaz, e ser feliz.Conhecer as manhas e as manhãs, O sabor das massas e das maçãs, É preciso amor pra poder pulsar, é preciso paz Pra poder sorrir, é preciso a chuva para florir.Ando devagar porque já tive pressa, E levo esse sorriso, porque já chorei de mais, Cada um de nós compõe a sua história, cada ser em si Carrega o dom de ser capaz, e ser ...