Vitamin B<sub>12</sub>and folate deficiency and elevated plasma total homocysteine in workers with chronic exposure to chromate

Wang, Tiancheng; Chen, Zhangjian; Zhang, Ji; Ma, Yan-Hui; Liu, Lanzheng; Zhang, Ning; Feng, Weiyue; Zhou, Jingwen; Song, Yanshuang; Yan, Lei; Du, Xianmei

doi:10.1136/oem.2010.063305

Cited by 11 publications

(7 citation statements)

References 38 publications

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“…When the coal is heated, chrome and chromate are found both as airborne solid particles and in a gaseous form in the air. Wang et al (2011) showed that serum vitamin B 12 and folate levels were decreased and significantly inversely correlated with chromium concentrations in red blood cells in the chromate exposed workers. The same authors also found that oxidative DNA damage and global DNA hypomethylation were related to folate deficiency in chromate manufacturing workers (Wang et al, 2012).…”

Section: Discussionmentioning

confidence: 97%

Determinants of plasma homocysteine in coal miners.

Mungan

Çan²,

Kıran³

et al. 2013

Acta Biochim Pol

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Aim: Several studies suggest that coal miners are under risk of severe health problems such as cardiovascular, pulmonary, neurological, renal, hematological and musculoskeletal disorders. However, there are limited data on biochemical changes in underground workers. In our study we aimed to evaluate the association between serum homocysteine (Hcy), vitamin B 12 , cystatin C and folate levels in the blood of underground coal miners. Materials and Methods: Eighty one coal miners who work as underground or surface workers were recruited into our study. The study population was divided into two groups: the surface worker group (control group, n=33) and the underground worker group (n=48). The folate, vitamin B 12 , Hcy, cystatin C levels and body mass indexes (BMI) of both groups were measured and compared. Serum folate, Hcy and vitamin B 12 levels were measured with a competitive chemiluminescence immunassay. Serum levels of cystatin C were determined by the latex particle-enhanced turbidimetric method using a cystatin C kit. Urea values were measured with a kinetic method on an automated analyzer. Results: There were no statistically significant differences between the underground workers and surface workers in the urea, cystatin C and vitamin B 12 levels. High serum Hcy levels and low folate levels were found in underground workers compared with those in surface workers. The correlation between Hcy and folate levels was also statistically significant. Similarly, there was also a significant correlation between Hcy and vitamin B 12 , and between Hcy and cystatin C levels. Conclusions: Elevated Hcy levels may be associated with underground working but further research is necessary to understand the relation between elevated Hcy and increased prevalence of health problems in coal miners.

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Section: Discussionmentioning

confidence: 97%

Determinants of plasma homocysteine in coal miners.

Mungan

Çan²,

Kıran³

et al. 2013

Acta Biochim Pol

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“…Supplementation with vitamins B12 and folic acid reduce the levels of homocysteine, and help prevent the occurrence of both primary and secondary stroke (Yang et al 2006;Wang et al 2007Wang et al , 2011Bhargava et al 2012b;Obeid et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Early markers of occult megaloblastosis for low-cost detection of hyperhomocysteinemia in patients with ischaemic stroke: preventive approach for primary health care

Neogi

Thomas

Sharma

et al. 2014

Can. J. Physiol. Pharmacol.

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Recent studies have focussed on the association between elevated homocysteine levels with megaloblastic changes and thromboembolic events, but the relationship between occult megaloblastosis (with normal haemoglobin levels) and ischaemic stroke has not been widely explored. The objective of this study is to establish a simple and economical marker for the detection of occult megaloblastosis at the community health care level in developing countries. A hundred patients who met the inclusion criteria were studied. At the 5% level of significance, the levels of cobalamin and folate were significantly lower, while the number of hypersegmented neutrophils on the peripheral smear was higher in patients from Group A (70 patients with high homocysteine) compared with the patients in Group B (30 patients with normal homocysteine). Forty-five (64.2%) of the 70 patients in Group A showed hypersegmentation of neutrophils in the peripheral smear. The high cost and difficulty in performing the vitamin assays limit their use as early markers of megaloblastosis. Hence, we conclude that in developing countries, the detection of hypersegmented neutrophils can be used at the primary healthcare level for early diagnosis of occult megaloblastosis, so that early therapeutic interventions with vitamins can prevent attacks of hyperhomocysteinemia-induced ischaemic stroke.

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“…Further studies have suggested that Cr can accumulate in the kidney tissues, causing both tubular and glomerular renal impairment. The kidney was considered the target organ of Cr toxicity [79]. Previous studies have shown the importance of kidney for the metabolism of Vitamin B 12 and folate; the alteration of vitamins' metabolism may be a consequence of kidney disease [79].…”

Section: Chromium (Cr)mentioning

confidence: 99%

“…The kidney was considered the target organ of Cr toxicity [79]. Previous studies have shown the importance of kidney for the metabolism of Vitamin B 12 and folate; the alteration of vitamins' metabolism may be a consequence of kidney disease [79]. Vitamin B 12 and folate deficiency can cause elevated blood concentrations of Hc, which is associated with an increased risk of developing cardiovascular diseases [80].…”

Section: Chromium (Cr)mentioning

confidence: 99%

“…Although the adverse effects of Cr on DNA and the damage caused are well-known, there are no published data on the metabolic changes of folates, Vitamin B 12 , and Hc in chronically exposed workers. The relationship between Vitamin B 12 levels, folates, Hc, and Cr exposure in workers of chromate manufactured articles has not been studied, and information on the effect of renal impairment on Vitamin B 12 , folates, and plasma levels of total Hc is lacking [79].…”

Section: Chromium (Cr)mentioning

confidence: 99%

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Exposure to Toxic Heavy Metals Can Influence Homocysteine Metabolism?

et al. 2019

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Background: Homocysteine is a sulfur amino acid whose metabolism is activated in two pathways: remethylation to methionine, which requires folate and vitamin B 12 , and transsulfuration to cystathionine, which needs pyridoxal-5'-phosphate. High homocysteine level increases the risk of developing heart disease, stroke, peripheral vascular diseases, and cognitive impairment. Some evidence showed that exposure to these metals increased plasma homocysteine levels. Methods: A systematic review was carried out to clarify the relationship between homocysteine blood levels and exposure to toxic heavy metals (Lead, Cadmium, Mercury, and Chromium). Results: The results of this systematic review indicate that exposure to Pb, Cr, Cd, and Hg is connected with nonphysiological homocysteine levels or vitamin B 12 and folate serum concentrations. Conclusions: These findings reinforce the importance of involvement in exposure to heavy metals in homocysteine metabolism. This supports the role of blood metals as potential upstream modifiable risk factors to prevent the development of other established risk factors as hyperhomocysteinemia.

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Vitamin B₁₂and folate deficiency and elevated plasma total homocysteine in workers with chronic exposure to chromate

Abstract: Hyperhomocysteinemia in chronically exposed workers was primarily induced by vitamin B12 and folate deficiency. This metabolic change might be associated with renal dysfunction in chromate processing workers after long term exposure.

Cited by 11 publications

References 38 publications

Determinants of plasma homocysteine in coal miners.

Determinants of plasma homocysteine in coal miners.

Early markers of occult megaloblastosis for low-cost detection of hyperhomocysteinemia in patients with ischaemic stroke: preventive approach for primary health care

Exposure to Toxic Heavy Metals Can Influence Homocysteine Metabolism?

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Vitamin B12and folate deficiency and elevated plasma total homocysteine in workers with chronic exposure to chromate

Abstract: Hyperhomocysteinemia in chronically exposed workers was primarily induced by vitamin B12 and folate deficiency. This metabolic change might be associated with renal dysfunction in chromate processing workers after long term exposure.

Cited by 11 publications

References 38 publications

Determinants of plasma homocysteine in coal miners.

Determinants of plasma homocysteine in coal miners.

Early markers of occult megaloblastosis for low-cost detection of hyperhomocysteinemia in patients with ischaemic stroke: preventive approach for primary health care

Exposure to Toxic Heavy Metals Can Influence Homocysteine Metabolism?

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Vitamin B₁₂and folate deficiency and elevated plasma total homocysteine in workers with chronic exposure to chromate