VITAMIN B<sub>12</sub> METABOLISM IN THALASSEMIA MAJOR*

Luhby, A. Leonard; Cooperman, Jack M.; Lopez, Rafael; Giorgio, Anthony J.

doi:10.1111/j.1749-6632.1969.tb27816.x

Cited by 8 publications

(10 citation statements)

References 24 publications

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“…Anaemia affects a significant proportion of children in developing countries. Nutritional deficiencies like iron, vitamin B 12 and folic acid are also very frequent in these areas [19]. So for treatment of anaemia, we need detailed evaluation to find out the exact cause.…”

Section: Discussionmentioning

confidence: 99%

“…According to a study by Crayn et al, the most important PBF findings of vitamin B 12 and folic acid deficiency are macrocytic RBCs and hypersegmented neutrophils [22]. This increase in RBCs size may be masked by microcytosis of co-existing iron deficiency or thalassemia.…”

Section: Discussionmentioning

confidence: 99%

“…Role of vitamin B12 and Folic acid-Vitamin B 12 and folic acid are essential nutrients for erythropoiesis. Deficiency of either of these vitamins leads to megaloblastic anaemia [10].…”

Section: International Journal Of Medical Research and Reviewmentioning

confidence: 99%

“…Reports on vitamin B 12 status in thalassemic patients are at variance. [12] In homozygous beta thalassemia, erythropoiesis is depressed. The cause can be iron overload [13] or deficiency of these vitamins.…”

Section: International Journal Of Medical Research and Reviewmentioning

confidence: 99%

“…These parameters were measured on Access-2 chemiluminescence machine. Measurement of vitamin B 12 and folic acid is based on the principle of competitive binding immunoenzymatic assay. [16] Vitamin B 12 or folic acid in the sample binds to the conjugate, preventing the conjugate from binding to the solid phase antibody.…”

Section: Investigationsmentioning

confidence: 99%

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Role of Estimation of Serum Ferritin, Vitamin B12 and Folic Acid in Management of Beta Thalassemic Children

Singla

Goyal

2016

Int J Med Res Rev

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Objective: To estimate the levels of serum Ferritin, Vitamin B 12 and Folic acid in beta thalassemic children. Introduction: Beta thalassemia is the most common genetically transmitted haematological disorder in Indian children. In thalassemia, there is ineffective erythropoiesis which can be either due to excess iron accumulation, or low vitamin B 12 and folate status. Study Design: The case-control study was carried out at G.G.S. Medical College and Hospital, Faridkot in department of Biochemistry in collaboration with department of Paediatrics. Materials and methods: In this case-control study, 50 children with with beta thalassemia major in the age group of 4 to 8 years were studied for estimation of serum ferritin, vitamin B 12 and folic acid. The control group consisted of 50 age and sex matched healthy children. Results: The study group had much higher serum ferritin levels as compared to healthy controls (p< 0.001). On other hand, the thalassemic children had much lower vitamin B 12 level in comparison with healthy controls (p< 0.001). The folic acid levels were also much lower in thalassemic children as compared to healthy controls (p< 0.001). Conclusion: Biochemical screening for levels of serum ferritin, vitamin B 12 and folic acid is of paramount importance in management of thalassemic children. Supplementation of vitamin B 12 and folic acid could be helpful to improve erythropoiesis in thalassemic children who have proven deficiency of these vitamins, though further studies are needed to establish this hypothesis. Figure-1: Scatter plot showing correlation between serum ferritin and vitamin B12 levelsAs can seen from above figure, with increase in serum ferritin levels, there was corresponding decrease in the levels of serum vitamin B 12 in beta thalassemic children. Pearson's correlation coefficient (r value of -0.7245) indicates strong negative correlation between serum ferritin and serum vitamin B 12 levels. Figure-2: Scatter plot showing correlation between serum ferritin and folic acid levelsAs can see from above figure, with increase in serum ferritin levels, there was corresponding decrease in the levels of serum folic acid in beta thalassemic children. Pearson's correlation coefficient (r value of -0.4836) indicates strong negative correlation between serum ferritin and serum folic acid levels.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Role of vitamin B12 and Folic acid-Vitamin B 12 and folic acid are essential nutrients for erythropoiesis. Deficiency of either of these vitamins leads to megaloblastic anaemia [10].…”

Section: International Journal Of Medical Research and Reviewmentioning

confidence: 99%

Section: International Journal Of Medical Research and Reviewmentioning

confidence: 99%

Section: Investigationsmentioning

confidence: 99%

See 3 more Smart Citations