Vitamin B12: An efficient type catalyst for the one-pot synthesis of 3,4,5-trisubstituted furan-2(5 H )-ones and N -aryl-3-aminodihydropyrrol-2-one-4-carboxylates

Efficient and Eco‐Friendly One‐Pot Synthesis of Functionalized Furan‐2‐one, Pyrrol‐2‐one, and Tetrahydropyridine Using Lemon Juice as a Biodegradable Catalyst

“…Previously, furan‐2‐ones have been prepared by employing β‐cyclodextrin, SnCl 2 .2H 2 O, ZnO nanoparticles, [Bu 4 N][HSO 4 ], sucrose, N ‐methyl 2‐pyrrolidonium hydrogen sulfate ([ H ‐NMP]HSO 4 ), SnO nanoparticles, HY Zeolite nano‐powder, watermelon juice, barberry juice, Vitamin B12, and graphene oxide (GO) as catalysts. Moreover, for the synthesis of pyrrol‐2‐ones, literature shows several methods with different catalysts which include acetic acid, I 2 , 1‐methyl‐2‐oxopyrrolidinium hydrogen sulfate ([Hpyro][HSO 4 ]), Cu(OAc) 2 ⋅H 2 O, TiO 2 nanopowder, trityl chloride, [n‐Bu 4 N][HSO 4 ], InCl 3, (S)‐camphorsulfonic acid, nanoZnO, vitamin B12, ethylenediammoniumdiformate (EDDF), 2,6‐pyridinedicarboxylic acid, UiO‐66‐SO 3 H metal‐organic framework, magnetic metal‐organic framework‐based catalyst CoFe 2 O 4 @SiO 2 @IRMOF‐3, Fe 3 O 4 @nano‐cellulose‐OPO 3 H, N,N,N,N ‐tetramethyl guanidinium acetate [TMG][Ac], graphene oxide (GO) etc . Despite the effectiveness of these catalysts, the usage of some of these methods are allied with several short comings such as harsh reaction conditions,, use of stoichiometric amounts of catalysts, prolonged reaction time,,,, difficulty in product isolation,,, and co‐occurrence of side reactions.…”

An Organocatalytic Novel Synthesis of Polyfunctionalized Bis-2,5-dihydrofuran-3-carboxylates via Domino-MCR Strategy

“…However, a quite number of synthetic methods have been reported with interesting merits and demerits of their own for the preparation of mono 2,5‐dihydrofuran‐3‐carboxylate derivatives by employing AcOH, [H‐NMP]HSO 4 , [Bu 4 N][HSO 4 ], β‐cyclodextrin, Al(HSO 4 ) 3 , lactic acid, vitamin B 12 , nano‐ZnO, HY Zeolite, SnO NPs and SnCl 2 as catalysts. Multicomponent reactions (MCRs) play a central role for the construction of pharmacologically and medicinally potent targets in a single operation leading to molecular complexity over regular multistep organic synthesis in terms of efficacy, economy and minimal waste production .…”

Piperidine‐Promoted Three‐Component Condensation: Synthesis of Chromene Heterocycles and Pyrazolotriazoles

“…Piperidine has been used as an organocatalyst in different organic syntheses . In continuation of our research on MCRs, we report here an efficient synthesis of 1,4‐dihydropyrano[2,3‐c]pyrazole, 5,10‐dihydro‐4 H ‐benzo[g]chromene, and pyrazolo[1,2‐ a ] [1,2,4]triazole derivatives in the presence of piperidine as an efficient catalyst in EtOH at ambient temperature (Scheme ).…”