Vitamin B12 concentrations in milk from Norwegian women during the six first months of lactation

Henjum, Sigrun; Manger, Mari S; Hampel, Daniela; Brantsæter, Anne Lise; Shahab‐Ferdows, Setareh; Bastani, Nasser E.; Strand, Tor A.; Refsum, Helga; Allen, Lindsay H.

doi:10.1038/s41430-020-0567-x

Cited by 11 publications

(9 citation statements)

References 22 publications

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“…However, studies on causality in these associations are needed. Whether postnatal exposures, such as infant vitamin B12 intake, could modify associations of vitamin B12-related differential methylation with child health also needs further study [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation

et al. 2023

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Circulating vitamin B12 concentrations during pregnancy are associated with offspring health. Foetal DNA methylation changes could underlie these associations. Within the Pregnancy And Childhood Epigenetics Consortium, we meta-analysed epigenome-wide associations of circulating vitamin B12 concentrations in mothers during pregnancy ( n = 2,420) or cord blood ( n = 1,029), with cord blood DNA methylation. Maternal and newborn vitamin B12 concentrations were associated with DNA methylation at 109 and 7 CpGs, respectively (False Discovery Rate P -value <0.05). Persistent associations with DNA methylation in the peripheral blood of up to 482 children aged 4–10 y were observed for 40.7% of CpGs associated with maternal vitamin B12 and 57.1% of CpGs associated with newborn vitamin B12. Of the CpGs identified in the maternal meta-analyses, 4.6% were associated with either birth weight or gestational age in a previous work. For the newborn meta-analysis, this was the case for 14.3% of the identified CpGs. Also, of the CpGs identified in the newborn meta-analysis, 14.3% and 28.6%, respectively, were associated with childhood cognitive skills and nonverbal IQ. Of the 109 CpGs associated with maternal vitamin B12, 18.3% were associated with nearby gene expression. In this study, we showed that maternal and newborn vitamin B12 concentrations are associated with DNA methylation at multiple CpGs in offspring blood ( P FDR <0.05). Whether this differential DNA methylation underlies associations of vitamin B12 concentrations with child health outcomes, such as birth weight, gestational age, and childhood cognition, should be further examined in future studies.

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Section: Discussionmentioning

confidence: 99%

A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation

et al. 2023

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“…Vitamin B 12 content in human milk depends on maternal status and intake of this vitamin [32]. The intake of vitamin B 12 during the lactation period should be 2 µg per day [19].…”

Section: Discussionmentioning

confidence: 99%

Mineral and Vitamin Intakes of Latvian Women during Lactation Period

Aumeistere

Beluško

Ciproviča

et al. 2022

Foods

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Studies from Europe and the United States indicate that women during the lactation period do not consume sufficient amounts of essential micronutrients. Previously reported data from Latvia indicates a low vegetable, fruit, fish, cereal, and milk and dairy products intake among lactating women. This raises concerns that nutrient (especially minerals and vitamins) intakes could also be insufficient. Therefore, this study aimed to assess mineral and vitamin intakes among lactating women in Latvia in comparison to nutritional guidelines at both a national and European level. 72-h food diaries were collected from 62 participants during the period November 2016 till December 2017 and from 68 participants during the period from January 2020 to December 2020. This also allowed us to evaluate whether nutrient intakes among lactating women in Latvia have changed in recent years. The Fineli Food Composition Database was used to calculate micronutrient intakes among the participants. MS Excel 2019 and IBM SPSS Statistics 23 were used for the statistical data analysis. The results revealed that dietary intakes of calcium, iron, iodine, and vitamins A, D, B1, and B9 among the participants of both study periods did not meet dietary recommendations. Low mineral and vitamin intakes could potentially affect the composition of human milk, and therefore micronutrient intakes, for breastfed infants. This indicates a need to develop dietary guidelines in order to improve diets among lactating women in Latvia.

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“…Despite a higher milk intake with increasing age, daily vitamin B 12 intake is reduced from 2 weeks to 6 months in exclusively breast-fed infants ( 8 , 45 , 69 , 70 ).…”

Section: Dietary Intake In Nordic and Baltic Countriesmentioning

confidence: 99%

Vitamin B12 – a scoping review for Nordic Nutrition Recommendations 2023

Bjørke-Monsen,

Lysne

2023

Food & Nutrition Research

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Vitamin B 12 (cobalamin) is essential for normal metabolic function, and even moderate deficiency of this vitamin has negative health effects. Vitamin B 12 is found in animal foods, and as vegetarian diets are increasingly popular in Western countries, one might expect a higher prevalence of vitamin B 12 deficiency in the Nordic population. Setting recommendations for vitamin B 12 intake has proven to be difficult, as uptake of vitamin B 12 varies substantially, the clinical deficiency symptoms are often diffuse, and there is no clear agreement on the decision limits for vitamin B 12 deficiency. Vitamin B 12 deficiency is reported to be particularly common among pregnant women and infants, despite the fact that less than 1% of Norwegian pregnant women have a cobalamin intake below the Nordic Nutrition Recommendations 2012-recommended level of 2.0 µg/day. In addition, the assumption that breast milk contains sufficient vitamin B 12 for optimal health and neurodevelopment during the first 6 months of life does not comply with the high prevalence of insufficient vitamin B 12 status in this age group. Recommended intakes of vitamin B 12 vary among age groups and must be based on markers of cobalamin status, indicating an optimal intracellular biochemical status, and not merely absence of clinical signs of vitamin B 12 deficiency.

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Vitamin B12 concentrations in milk from Norwegian women during the six first months of lactation

Cited by 11 publications

References 22 publications

A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation

A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation

Mineral and Vitamin Intakes of Latvian Women during Lactation Period

Vitamin B12 – a scoping review for Nordic Nutrition Recommendations 2023

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