Vitamin B12 Deficiency: A Cause of Abnormal Movements in Infants

Emery, Edward S.; Homans, Alan C.; Colletti, Richard B.

doi:10.1542/peds.99.2.255

Cited by 60 publications

(66 citation statements)

References 9 publications

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“…The duration of movement disorder is 10-30 d. The severity, nature, and timing of movement disorder are highly variable [1,4,7]. Jadhav et al [9] first described nutritional vitamin B12 deficiency in 6 Indian infants aged 6-12 months that presented with megaloblastic anemia, psychomotor regression, and hyper pigmentation of the skin.…”

Section: Discussionmentioning

confidence: 99%

“…Changes in the plasma concentration of various amino acids were observed in response to vitamin B12 treatment. Although it has been proposed that hyperglycinemia is responsible for the involuntary movement observed in response to vitamin B12 treatment [7], it was also reported that glycine levels were normal [11]. It was reported that EEG results in patients with seizures due to vitamin B12 deficiency were abnormal, whereas normal EEG results were observed in patients with tremors and myoclonus [1,12,13,16].…”

Section: Discussionmentioning

confidence: 99%

“…As such, it was reported that use of antiepileptics was unnecessary and useless in patients with involuntary movements [1,10,16]. It is thought that involuntary movements is self-restricted and there is no consensus on the use of antiepileptic treatment [7,10].…”

Section: Discussionmentioning

confidence: 99%

“…Severe neurological findings, such as hypotonia, apathy, decreased eye contact, involuntary movement, seizure, lethargy, and coma, have been reported [1,3,4,7,8]. A delay in the diagnosis and treatment of vitamin B12 deficiency can lead to irreversible psychomotor retardation and neurological damage.…”

Section: Introductionmentioning

confidence: 99%

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Involuntary movements during vitamin B12 treatment in infants

Tosun¹,

Yz²,

Çeçen³

et al. 2011

Turk J Hematol

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Megaloblastic anemia is rare in infants and is generally due to vitamin B12 (cobalamin) deficiency in the mother. Neurologic symptoms of vitamin B12 deficiency include irritability, failure to thrive, hypotonia, and developmental regression/delay. Herein we present 2 infants with vitamin B12 that developed movement disorder 5 d after initiation of vitamin B12 treatment. Symptoms included tremor and myoclonus, involving in particular the face, tongue, and hands. Clinical findings in infants associated with vitamin B12 deficiency vary, and temporary involuntary movement can be observed during vitamin B12 therapy. (Turk J Hematol 2011; 28: 317-22) Key words: Involuntary movement, vitamin B12 deficiency, infant Received: June 11, 2010 Accepted: October 19, 2010 Özet Süt çocuklarında megaloblastik anemi nadirdir ve genellikle annelerdeki vitamin B12 eksikliğinin bir sonucudur. Kobalamin eksikliğinin nörolojik semptomları huzursuzluk, büyüme geriliği, hipotoni ve nöro-gelişimsel becerilerde gerileme/gecikmeyi içerir. Bu makalede kobalamin tedavisinin 5. gününde özellikle dil, yüz, elleri içine alan tremor ve miyoklonus gibi istemsiz hareketler gelişen, kobalamin eksikliği olan, iki süt çocuğu sunuldu. Süt çocuklarında kobalamin eksikliği farklı klinik bulgularla karşımıza gelebilir ve tedavisi sırasında geçici istemsiz hareketler görülebilir. (Turk J Hematol 2011; 28: 317-22)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Involuntary movements during vitamin B12 treatment in infants

Tosun¹,

Yz²,

Çeçen³

et al. 2011

Turk J Hematol

View full text Add to dashboard Cite

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“…B 12 is therefore important for enabling central nervous system functions, and it is not surprising that central nervous system deficits appear in vitamin B 12 -deficient infants. B 12 deficiency can cause growth retardation, neutropenia, skin lesions, frequent infections, tremors, irritability, hypotonia, and seizure, among other symptoms (7)(8)(9)(10)(11). Simultaneous investigation of the mother and infant especially an infant breastfed by a mother with vitamin B 12 deficiency is important for the early detection of vitamin B 12 deficiency and initiation of nutritional support before significant neurological symptoms develop.…”

Section: Introductionmentioning

confidence: 99%

How Does B12 Deficiency of Mothers Affect Their Infants?

et al. 2017

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Background: Vitamin B12 cannot be synthesized in the body and it is essential for growth and development in humans. Objectives: To evaluate the vitamin B12 levels between the mothers and their infants who presented to the Pediatric Hematology outpatients department due to the symptoms of vitamin B12 deficiency. We also compared the effects of low B12 levels in both the mother and the child, compared to the effects of normal B12 levels in the mother and low levels in the child. Methods: We enrolled 303 children aged 2 -18 months between January 2013 and September 2015. Patients with a vitamin B12 level < 200 pg/mL in both the mother and the child and patients with a B12 level that was low in the child and normal in the mother were compared. Results: The birth weight of the children was low in the group where the B12 level of both the mother and the child (n = 163) was low and presentation to the clinic with neurologic signs and symptoms such as tremor, restlessness, seizure, hypotonia, and macrocephaly not related to another etiologic reason was common (P < 0.05). A remarkable finding was the simultaneous low levels of vitamin B12 in the mother in 55 of the 69 children who presented with neurological symptoms (P < 0.05). A generalized or focal epileptic pathology was found in the EEGs and MR images including retardation in myelination, demyelination, atrophic findings or ventricular dilatation in children whose mothers have B12 deficiency simultaneously. Conclusions: It is difficult to explain such complicated clinical pictures due to malnutrition especially in developing countries. Detecting and treating vitamin B12 deficiency early in mother and child is very important in prevention of potential irreversible neurological problems.

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Neuropathy in two cobalamin-deficient breast-fed infants of vegetarian mothers

et al. 1999

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We describe the electrophysiological findings in 2 infants with deficient cobalamin intake. After normal development, psychomotor regression appeared after the 6th month, leading to severe hypotonia and apathy before the 12th month. Electrodiagnostic evaluation showed sensory neuropathy in both cases, associated with motor neuropathy in 1 case. Thus, in an acquired floppy infant syndrome, electrophysiological signs of peripheral neuropathy contributed to the diagnosis of a curable metabolic disorder. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 252–254, 1999

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Vitamin B12 Deficiency: A Cause of Abnormal Movements in Infants

Cited by 60 publications

References 9 publications

Involuntary movements during vitamin B12 treatment in infants

Involuntary movements during vitamin B12 treatment in infants

How Does B12 Deficiency of Mothers Affect Their Infants?

Neuropathy in two cobalamin-deficient breast-fed infants of vegetarian mothers

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