Vitamin B12 deficiency anemia in an exclusively breastfed infant born to an ileum-resected mother

Tamura, Akihiro; Nino, Nanako; Yamamoto, Nobuyuki; Naito, Akiyoshi; Matsubara, Kousaku; Nakatani, Naoko; Ichikawa, Takayuki; Nakamura, Sayaka; Saito, Atsuro; Kozaki, Aiko; Kishimoto, Kenji; Ishida, Toshiaki; Shigematsu, Yosuke; Hasegawa, Daiichiro; Kosaka, Yoshiyuki

doi:10.1016/j.pedneo.2019.06.002

Cited by 2 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vitamin B12 is essential for normal blood formation, cell synthesis, and neurological functions in the human body . Low levels of vitamin B12 can lead to diseases mainly manifested in the blood, metabolism, and nervous system, such as high homocysteinemia, anemia, paraesthesia, cognitive impairments, depression, methylmalonic acidemia, vascular dementia, and Alzheimer's disease . Vitamin B12 deficiency during pregnancy and childhood is associated with poor infant growth, impaired psychomotor function, and abnormal brain development .…”

Section: Introductionmentioning

confidence: 99%

A preliminary study for the establishment of a reference interval for vitamin B12 in China after performance verification of a second‐generation ECLIA kit

Jiang

Men

Wen

et al. 2020

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background:The second-generation electrochemiluminescence immunoassay (ECLIA) kit of vitamin B12 is widely used in clinical laboratories, and the establishment of a reference interval (RI) is essential to provide the basis for clinical monitoring. The purpose of this study was to establish a laboratory RI for vitamin B12 in China and at the same time verify the method performance of the second-generation kit. Methods:The verification of the method performance was conducted according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Based on these guidelines, a total of 580 serum samples were collected, and 391 serum samples were used for the establishment of the RI according to CLSI guidelines. The subjects were grouped by sex and age. The age groups were as follows: 21-40, 41-60, and 61-80 years. The RI was defined by nonparametric 2.5th and 97.5th percentile intervals. Results:The performance of the second-generation kit of vitamin B12 from the Roche Cobas E602 system was in compliance with laboratory requirements. Serum vitamin B12 levels conformed to a non-Gaussian distribution. Harris-Boyd's test did not indicate partitioning for different age and gender group. Besides, there was no significant difference between different age groups (P = .07) and gender groups (P = .2002). The RI for healthy Chinese adults (aged 21-80 years) calculated by the nonparametric method was 250.8-957.1 pg/mL. Conclusions:The reference range of vitamin B12 was established, which provided a theoretical basis for the clinical application and monitoring of vitamin B12 detection. K E Y W O R D SChinese, electrochemiluminescent, performance verification, reference interval, Vitamin B12

show abstract

Section: Introductionmentioning

confidence: 99%

A preliminary study for the establishment of a reference interval for vitamin B12 in China after performance verification of a second‐generation ECLIA kit

Jiang

Men

Wen

et al. 2020

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

Biochemical, Nutritional, and Clinical Parameters of Vitamin B12 Deficiency in Infants: A Systematic Review and Analysis of 292 Cases Published between 1962 and 2022

Wirthensohn,

Wehrli,

Ljungblad

et al. 2023

Nutrients

View full text Add to dashboard Cite

Pooled data from published reports on infants with clinically diagnosed vitamin B12 (B12) deficiency were analyzed with the purpose of describing the presentation, diagnostic approaches, and risk factors for the condition to inform prevention strategies. An electronic (PubMed database) and manual literature search following the PRISMA approach was conducted (preregistration with the Open Science Framework, accessed on 15 February 2023). Data were described and analyzed using correlation analyses, Chi-square tests, ANOVAs, and regression analyses, and 102 publications (292 cases) were analyzed. The mean age at first symptoms (anemia, various neurological symptoms) was four months; the mean time to diagnosis was 2.6 months. Maternal B12 at diagnosis, exclusive breastfeeding, and a maternal diet low in B12 predicted infant B12, methylmalonic acid, and total homocysteine. Infant B12 deficiency is still not easily diagnosed. Methylmalonic acid and total homocysteine are useful diagnostic parameters in addition to B12 levels. Since maternal B12 status predicts infant B12 status, it would probably be advantageous to target women in early pregnancy or even preconceptionally to prevent infant B12 deficiency, rather than to rely on newborn screening that often does not reliably identify high-risk children.

show abstract

Vitamin B12 deficiency anemia in an exclusively breastfed infant born to an ileum-resected mother

Cited by 2 publications

References 6 publications

A preliminary study for the establishment of a reference interval for vitamin B12 in China after performance verification of a second‐generation ECLIA kit

A preliminary study for the establishment of a reference interval for vitamin B12 in China after performance verification of a second‐generation ECLIA kit

Biochemical, Nutritional, and Clinical Parameters of Vitamin B12 Deficiency in Infants: A Systematic Review and Analysis of 292 Cases Published between 1962 and 2022

Contact Info

Product

Resources

About