2018
DOI: 10.1016/j.jnim.2017.12.001
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Vitamin B12 deficiency in diabetic subjects taking metformin: A cross sectional study in a Lebanese cohort

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Cited by 18 publications
(22 citation statements)
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“…Based on DM complication, we found that the mean of Vitamin B 12 level among patients on metformin that suffered from DM complication was 296.67±157.21, in compared with DM patients without complications was 457.09±201.94 (95%CI=76.47-244.39, P= 0.00), which increases the risk of DM complications 2.7 times (OR Ratio=2.7, 95% CI=1.4-5.03). This result with agreement with those one conducted in Lebanon (Zalaket J. et al, 2018).…”
Section: Resultssupporting
confidence: 94%
“…Based on DM complication, we found that the mean of Vitamin B 12 level among patients on metformin that suffered from DM complication was 296.67±157.21, in compared with DM patients without complications was 457.09±201.94 (95%CI=76.47-244.39, P= 0.00), which increases the risk of DM complications 2.7 times (OR Ratio=2.7, 95% CI=1.4-5.03). This result with agreement with those one conducted in Lebanon (Zalaket J. et al, 2018).…”
Section: Resultssupporting
confidence: 94%
“…Previous studies have been published to find a correlation between diabetic neuropathy and vitamin B12 deficiency, but they are descriptive studies and have not been conclusive (8, 27, 28, 29, 30). Gupta et al (27) found a positive correlation between metformin use time and diabetic neuropathy and a negative correlation between metformin use time and vitamin B12 levels.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, to draw clinically significant conclusions, it is recommended that further investigations proceed with larger cohorts, and include biochemical tests for methylmalonic acid and homocysteine levels, considering that these have been identified as better indicators of functional vitamin B 12 deficiency than actual serum vitamin B 12 level itself. 33 , 34 …”
Section: Strengths and Limitationsmentioning
confidence: 99%