Vitamin B12 deficiency in patients with chronic-tinnitus and noise-induced hearing loss

Shemesh, Zecharia; Attias, Joseph; Ornan, Michal; Shapira, Niva; Shahar, Amir

doi:10.1016/0196-0709(93)90046-a

Cited by 64 publications

(57 citation statements)

References 16 publications

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“…Auditory dysfunction has been associated with deficiencies of several micronutrients in humans (6)(7)(8)(9) and young growing animals (10)(11)(12)(13)(14). However, we found no studies in humans or experimental animals that specifically examined the role of nutrition in age-related hearing loss.…”

Section: Introductioncontrasting

confidence: 43%

“…Anywhere from 5-15% of the elderly population may be vitamin B-12 deficient (18), and the prevalence of folate deficiency in the elderly has been estimated at 2-20% (19). We suspect that the roles of vitamin B-12 and folate in cellular metabolism, the nervous system, and vascular function (9,(20)(21)(22) are important for the auditory system.…”

Section: Introductionmentioning

confidence: 99%

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Age-related hearing loss, vitamin B-12, and folate in elderly women

Houston

Johnson

Nozza

et al. 1999

The American Journal of Clinical Nutrition

116

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Background: Hearing impairment is 1 of the 4 most prevalent chronic conditions in the elderly. However, the biological basis of age-related hearing loss is unknown. Objective: The objective was to test the hypothesis that agerelated hearing loss may be associated with poor vitamin B-12 and folate status. Design: A thorough audiometric assessment was conducted in 55 healthy women aged 60-71 y. Hearing function was determined by the average of pure-tone air conduction thresholds at 0.5, 1, 2, and 4 kHz and was categorized into 2 groups for logistic regression analyses: normal hearing (< 20 dB hearing level; n = 44) and impaired hearing (≥ 20 dB hearing level; n = 11). Results: Mean age was the same (65 y) for the normal hearing and impaired hearing groups. Pure-tone averages were inversely correlated with serum vitamin B-12 (r = Ϫ0.58, P = 0.0001) and red cell folate (r = Ϫ0.37, P = 0.01). Women with impaired hearing had 38% lower serum vitamin B-12 (236 compared with 380 pmol/L, respectively, P = 0.008) and 31% lower red cell folate (425 compared with 619 nmol/L, respectively, P = 0.02) than women with normal hearing. Among participants who did not take supplements containing vitamin B-12 or folate, women with impaired hearing had 48% lower serum vitamin B-12 (156 compared with 302 pmol/L, respectively, P = 0.0007) and 43% lower red cell folate (288 compared with 502 nmol/L, respectively, P = 0.001) than women with normal hearing. Conclusion: Poor vitamin B-12 and folate status may be associated with age-related auditory dysfunction.Am J Clin Nutr 1999;69:564-71.

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Section: Introductioncontrasting

confidence: 43%

Section: Introductionmentioning

confidence: 99%

Age-related hearing loss, vitamin B-12, and folate in elderly women

Houston

Johnson

Nozza

et al. 1999

The American Journal of Clinical Nutrition

116

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“…Because of relatively poor gastric absorption, B 12 can be taken as a sublingual tablet or by injection. Supplements range in strength from 50 lg to 2 mg. Megadose vitamin B 12 toxicity is unknown, and any excess is excreted from the body [14]. One can measure serum B 12 or serum methylmalonic acid for levels of this vitamin.…”

Section: Vitamin B 12mentioning

confidence: 99%

“…Shemesh et al [14] showed a high prevalence (47%) of vitamin B 12 deficiency in patients with chronic tinnitus when a criterion of deficiency is set at 250 pg/mL and lower. Serum cobalamin deficiency was more widespread and severe in the tinnitus group associated with noise exposure.…”

Section: Vitamin B 12mentioning

confidence: 99%

Alternative medications and other treatments for tinnitus: facts from fiction

Seidman

Babu

2003

Otolaryngologic Clinics of North America

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“…In fact, targeting mitochondria is becoming increasingly popular [82], and there were some successful attempts in treatment of hearing conditions using mitochondrial supplements [83][84][85][86][87][88][89].…”

Section: Mitochondrial Toxicity: Common Denominator Of Ototoxic Drugsmentioning

confidence: 99%

Ototoxicity: Old and New Foes

Szczepek¹

2017

Advances in Clinical Audiology

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Drug-induced ototoxicity has been known for centuries. Already in the seventeenth century, hearing loss was described to be a side effect of quinine. The post-World War II pharmaceutical industry boomed with the production of aminoglycoside antibiotics followed by diuretics and cytostatic drugs. Wide-spread and long-term usage of these medications brought the knowledge about their unwanted ototoxic effects. In the last decades, several new drugs appeared on the shelves of pharmacies and the hearing loss or tinnitus have been among the side effects of many of them. However, the awareness of community about new ototoxic medications is still not sufficient. New ototoxic drugs may belong to the class of phosphodiesterase-5 (PDE5) inhibitors, used to improve microcirculation and to treat erectile dysfunction. Moreover, interferons used for the therapy of hepatitis B and C, common painkiller paracetamol and hydrocodone, synthetic opioid methadone and the inhibitors of reverse transcriptase were demonstrated to induce adverse effects on hearing. Lastly, hearing loss linked to immunosuppressive drugs was documented in patients undergoing organ transplantation. Making the patients aware of adverse drug reactions and offering them audiological monitoring and intervention should be considered by respective therapists.

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Vitamin B12 deficiency in patients with chronic-tinnitus and noise-induced hearing loss

Cited by 64 publications

References 16 publications

Age-related hearing loss, vitamin B-12, and folate in elderly women

Age-related hearing loss, vitamin B-12, and folate in elderly women

Alternative medications and other treatments for tinnitus: facts from fiction

Ototoxicity: Old and New Foes

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