Vitamin B12 Hydrophobic Derivative Exhibits Bioactivity: Biomedical and Photophysical Study

The prospects for the use of vitamin B12 derivatives in pharmacology

“…Например, аквакобаламин можно использовать как противоядие при отравлении цианидами, нитропруссидом натрия, диаквакобинамид -антидот против цианида, сероводорода, метилмеркаптана [3], восстановленный гидроксокобаламин -антидот при остром отравлении угарным газом [26]. Диаквакобинамид и гидроксиаквакобинамид могут связывать до двух цианид-ионов, что можно использовать для фотометрического определения цианидов в поточном анализаторе [27].…”

“…[2]. Ион кобальта в кобаламинах может принимать различные степени окисления (Co(III), Co(II), Co(I)), поэтому эти молекулы весьма перспективно использовать в качестве катализаторов различных окислительно-восстановительных процессов [3], включая синтез лекарств и обезвреживание токсинов.…”

Supermolecular Nanoentities of Vitamin B12 Derivative as a Link in the Evolution of the Parent Molecules During Self-Assembly at the Air–Water Interface

“…Vitamin B 12 , which plays an essential role in living organisms, is a porphyrin-type biomolecule containing a central cobalt ion bound to a corrin ring. Vitamin B 12 derivatives, in particular, aquacyanocobyrinic acid heptamethyl ester, which is soluble in a wide range of organic solvents, have the same corrin ring as the natural vitamin B 12 , and their Co 3+ ion is reversibly reduced to Co 2+ and Co 1+ , which allows them to catalyze a wide variety of redox reactions. , Recently, we have shown that this compound exhibits biological activity, restoring the myelin sheath of neurons, and can be encapsulated for targeted delivery . Biomolecules used in synthetic biology can be a source of natural reactivity that can be molded by directed evolution to generate efficient entities with valuable activities.…”

High Reactivity of Supermolecular Nanoentities of a Vitamin B12 Derivative in Langmuir–Schaefer Films Toward Gaseous Toxins

“…These facts explain the higher efficacy of Cbis as a cyanide antidote in comparison with H 2 OCbl. − In contrast to H 2 OCbl, Cbis have been successfully employed as hydrogen sulfide antidotes as well. − The reaction between aquahydroxocobinamide and H 2 S proceeds more rapidly than that involving H 2 OCbl and results in the reduction of Co­(III) ion to Co­(II) and its sulfur-containing species (viz., Co­(II)-S • – and Co­(II)-SSH •2– ) via the transient generation of Co­(III)-hydrosulfido complexes. We have shown that vitamin B 12 derivatives, in particular aquacyanocobyrinic acid heptamethyl ester (heptamethyl cobyrinate), exhibit biological activity, restoring the myelin sheath of neurons, and can be encapsulated for targeted delivery …”

“…We have shown that vitamin B 12 derivatives, in particular aquacyanocobyrinic acid heptamethyl ester (heptamethyl cobyrinate), exhibit biological activity, restoring the myelin sheath of neurons, 19 and can be encapsulated for targeted delivery. 20 Cobalamins and their derivatives represent a promising platform for the development of chemosensors toward toxins as well.…”