Vitamin B12 status and folic acid/vitamin B12 related to the risk of gestational diabetes mellitus in pregnancy: a systematic review and meta-analysis of observational studies

He, Jin; Jiang, Dongmei; Cui, Xianwei; Ji, Chenbo

doi:10.1186/s12884-022-04911-9

Cited by 16 publications

(13 citation statements)

References 52 publications

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“…Unbalances in serum vitamin B12 and folic acid (folic acid and vitamin B12) are more strongly linked to gestational diabetes mellitus. Folic acid is a crucial vitamin during pregnancy since it plays a role in DNA methylation and the manufacture of proteins and nucleic acids needed for cell replication and embryonic growth [ 17 ]. A safe and viable strategy that may provide pregnant women exposed to free radicals with a way to reduce the risk of foetal growth decline is higher-dose folic acid supplementation.…”

Section: Resultsmentioning

confidence: 99%

Evaluating the Cost-Effectiveness of Folic Acid Versus Methyltetrahydrofolate in Preventing Preeclampsia in Makassar, Indonesia

Maulana Kamri,

Kosman,

Putra

2024

Cureus

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Background: Preeclampsia is a condition of elevated blood pressure with proteinuria that occurs during pregnancy and is a complication of elevated blood pressure. It usually occurs after the 20th week of pregnancy. This could be fatal for the mother after birth and the baby if it occurs before birth. The goal of this study is to investigate the risk, cost-effectiveness, and effective doses of folic acid (B9). Method: This study is an observational study with a cohort design and random simple sampling data collection. Data was collected from the Cahaya Ibu Pharmacy Store in Makassar from 164 patients. Result: Chi-square statistical analysis data showed a significant risk relationship between pregnant women and the development of hypertension compared with nonpregnant patients, with a p-value of 0.001. Her risk level for the event reaches twice, as evidenced by her odds ratio reaching 6.9 times. The results of cost analytics showed folic acid had an equal effect on women's reduced risk of preeclampsia as methyltetrahydrofolate. Conclusions: Using folic acid early in pregnancy planning is a great opportunity to reduce the incidence of preeclampsia. The ICER value was obtained at $0.293, so an increase in the cost of that amount was needed to improve the effectiveness of therapy by patients using folic acid compared to patients with methyltetrahydrofolate therapy. Therefore, folic acid is more cost-effective compared to methyltetrahydrofolate.

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Section: Resultsmentioning

confidence: 99%

Evaluating the Cost-Effectiveness of Folic Acid Versus Methyltetrahydrofolate in Preventing Preeclampsia in Makassar, Indonesia

Maulana Kamri,

Kosman,

Putra

2024

Cureus

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“…However, it is essential to acknowledge certain limitations of this study. First, it has been reported that vitamin B 12 and folate act as cofactors in regulating HCY levels, and vitamin B 12 deficiency has been associated with GDM 48 . Unfortunately, due to limitations in LC‐MS/MS technology, we were unable to measure vitamin B 12 .…”

Section: Discussionmentioning

confidence: 98%

“…First, it has been reported that vitamin B 12 and folate act as cofactors in regulating HCY levels, and vitamin B 12 deficiency has been associated with GDM. 48 Unfortunately, due to limitations in LC-…”

Section: Discussionmentioning

confidence: 99%

Gestational diabetes mellitus is associated with distinct folate‐related metabolites in early and mid‐pregnancy: A prospective cohort study

Zheng,

Zhang,

Zhang

et al. 2024

Diabetes Metabolism Res

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AimsThis study aimed to evaluate the association between gestational diabetes mellitus (GDM) and circulating folate metabolites, folic acid (FA) intake, and the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genotype.Materials and MethodsA prospective pregnancy cohort study was conducted in Beijing, China, from 2022 to 2023. Circulating folate metabolites, including red blood cell (RBC) 5‐methyltetrahydrofolate (5‐MTHF), 5, 10‐methylene‐tetrahydrofolate (5,10‐CH2‐THF), 5‐ formyltetrahydrofolate (5‐CHO‐THF), and unmetabolised folic acid (UMFA), and plasma homocysteine (HCY), 5‐MTHF, and methylmalonic acid (MMA), were determined at 6–17 weeks and 20–26 weeks of gestation. FA intake and the MTHFR and MTRR genotype were also examined. GDM was diagnosed between 24 and 28 weeks of pregnancy by a 75‐g oral glucose tolerance test (OGTT). The association between the folate status and GDM was ascertained using multivariate generalised linear models, logistic regression models, and restricted cubic spline regression, adjusting for potential confounders.ResultsThe study included 2032 pregnant women, of whom 392 (19.29%) developed GDM. UMFA above the 75th percentile (≥P75) [adjusted OR (aOR) (95% confidence interval [CI]) = 1.36 (1.01–1.84)], UMFA ≥ P90 [aOR (95% CI) = 1.82 (1.23–2.69)], and HCY ≥ P75 [aOR (95% CI) = 1.40 (1.04–1.88)] in early pregnancy, and RBC 5‐MTHF [aOR (95% CI) = 1.48 (1.10–2.00)], RBC 5,10‐CH2‐THF [aOR (95% CI) = 1.55 (1.15–2.10)], and plasma 5‐MTHF [aOR (95% CI) = 1.36 (1.00–1.86)] in mid‐pregnancy ≥ P75 are associated with GDM. Higher UMFA levels in early pregnancy show positive associations with the 1‐h and 2‐h glucose levels during the OGTT, and higher HCY levels are associated with increased fasting glucose levels during the OGTT. In comparison, RBC 5‐ MTHF and 5,10‐CH2‐THF, and plasma 5‐ MTHF in mid‐pregnancy are positively associated with the 1‐h glucose level (p < 0.05). The MTHFR and MTRR genotype and FA intake are not associated with GDM.ConclusionsElevated levels of UMFA and HCY during early pregnancy, along with elevated RBC 5‐MTHF and 5,10‐CH2‐THF and plasma 5‐MTHF during mid‐pregnancy, are associated with GDM. These findings indicate distinct connections between different folate metabolites and the occurrence of GDM.

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“…The population studied had a high prevalence of vitamin D insufficiency, but the lack of an observed difference might have been related to the multiple-micronutrient format or the timing of the intervention [ 42 ]. B-group vitamins have also been related with maternal glycaemia [ 11 , 17 , 18 , 43 ], with maternal vitamin B12 deficiency associated with increased insulin resistance and adiposity among offspring [ 9 , 13 , 44 ]. Thus, the beneficial effects of supplementation on infant weight gain among our cohort could be related to improvements in nutritional sufficiency, though the mechanisms are unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Several micronutrients have been related to offspring adiposity, for example, increased adiposity has been observed among offspring whose mothers were vitamin D deficient during pregnancy [ 8 , 12 , 14 ]. Likewise, B-vitamin deficiencies have been observed among mothers with diabetes [ 10 , 11 , 17 , 18 ], which may contribute to increased offspring adiposity [ 9 , 13 ]. Similarly, myo -inositol, a non-essential sugar alcohol involved in regulating glucose and lipid metabolism, has been postulated to counteract the effects of maternal dysglycaemia and dyslipidaemia on offspring adiposity [ 19 ], and probiotics have been proposed as beneficial in preventing gestational dysglycemia [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of preconception and antenatal supplementation with myo-inositol, probiotics, and micronutrients on offspring BMI and weight gain over the first 2 years

Lyons-Reid,

Derraik,

Kenealy

et al. 2024

BMC Med

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Background Nutritional intervention preconception and throughout pregnancy has been proposed as an approach to promoting healthy postnatal weight gain in the offspring but few randomised trials have examined this. Methods Measurements of weight and length were obtained at multiple time points from birth to 2 years among 576 offspring of women randomised to receive preconception and antenatally either a supplement containing myo-inositol, probiotics, and additional micronutrients (intervention) or a standard micronutrient supplement (control). We examined the influence on age- and sex-standardised BMI at 2 years (WHO standards, adjusting for study site, sex, maternal parity, smoking and pre-pregnancy BMI, and gestational age), together with the change in weight, length, BMI from birth, and weight gain trajectories using latent class growth analysis. Results At 2 years, there was a trend towards lower mean BMI among intervention offspring (adjusted mean difference [aMD] − 0.14 SD [95% CI 0.30, 0.02], p = 0.09), and fewer had a BMI > 95th percentile (i.e. > 1.65 SD, 9.2% vs 18.0%, adjusted risk ratio [aRR] 0.51 [95% CI 0.31, 0.82], p = 0.006). Longitudinal data revealed that intervention offspring had a 24% reduced risk of experiencing rapid weight gain > 0.67 SD in the first year of life (21.9% vs 31.1%, aRR 0.76 [95% CI 0.58, 1.00], p = 0.047). The risk was likewise decreased for sustained weight gain > 1.34 SD in the first 2 years of life (7.7% vs 17.1%, aRR 0.55 [95% CI 0.34, 0.88], p = 0.014). From five weight gain trajectories identified, there were more intervention offspring in the “normal” weight gain trajectory characterised by stable weight SDS around 0 SD from birth to 2 years (38.8% vs 30.1%, RR 1.29 [95% CI 1.03, 1.62], p = 0.029). Conclusions Supplementation with myo-inositol, probiotics, and additional micronutrients preconception and in pregnancy reduced the incidence of rapid weight gain and obesity at 2 years among offspring. Previous reports suggest these effects will likely translate to health benefits, but longer-term follow-up is needed to evaluate this. Trial registration ClinicalTrials.gov, NCT02509988 (Universal Trial Number U1111-1171–8056). Registered on 16 July 2015.

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Vitamin B12 status and folic acid/vitamin B12 related to the risk of gestational diabetes mellitus in pregnancy: a systematic review and meta-analysis of observational studies

Cited by 16 publications

References 52 publications

Evaluating the Cost-Effectiveness of Folic Acid Versus Methyltetrahydrofolate in Preventing Preeclampsia in Makassar, Indonesia

Evaluating the Cost-Effectiveness of Folic Acid Versus Methyltetrahydrofolate in Preventing Preeclampsia in Makassar, Indonesia

Gestational diabetes mellitus is associated with distinct folate‐related metabolites in early and mid‐pregnancy: A prospective cohort study

Impact of preconception and antenatal supplementation with myo-inositol, probiotics, and micronutrients on offspring BMI and weight gain over the first 2 years

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