Vitamin B12 supplementation during pregnancy for maternal and child health outcomes

Finkelstein, Julia L; Fothergill, Amy; Venkatramanan, Sudha; Layden, Alexander J; Williams, Jennifer L; Crider, Krista S; Qi, Yan Ping

doi:10.1002/14651858.cd013823.pub2

“…Pregnant women and young children are at an increased risk of facing this deficiency. 4 Regional disparities in the occurrence of vitamin B12 deficiency throughout pregnancy have been observed, indicating varying levels of risks across different regions. 5 Inadequacy of vitamin B12 in pregnancy has been linked to unfavourable pregnancy outcomes, including spontaneous abortions, stillbirth, neural tube defects, intrauterine growth restriction, low birth weight, and premature delivery.…”

Section: Introductionmentioning

confidence: 99%

Association of maternal and cord vitamin B12 levels with anthropometry in term neonates born to malnourished mothers in coastal South India

GR,

Holla,

Manjrekar

et al. 2024

F1000Res

0

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Background Malnourished pregnant women are at increased risk of micronutrient deficiency. We assessed the vitamin B12 status in both malnourished and normally nourished pregnant women and their neonates. Additionally, we studied the association between maternal B12 levels, cord B12 levels and neonatal anthropometry. Methods This cross-sectional study enrolled 63 malnourished and 63 normally nourished mothers and neonates. Maternal and cord blood samples were collected at the time of delivery for estimation of vitamin B12 levels. Maternal and cord vitamin B12 levels were compared using the Mann–Whitney U test. Neonatal anthropometry was correlated with maternal and cord B12 levels using Spearman’s correlation. Data were analyzed using SPSS version 25. Results Mean maternal age was 26.58 yrs. The median cord B12 levels were lower than the maternal B12 levels. Maternal B12 levels showed a strong positive correlation with cord B12 levels (rho = 0.879; p < 0.001). Maternal (p < 0.001) and cord (p < 0.001) vitamin B12 levels were significantly lower in the malnourished group than in the normally nourished group. In malnourished group, 66.8% mothers and 95.2% neonates were Vitamin B12 deficient, whereas 1.5% mothers and 4.7% neonates were vitamin B12 deficient in normally nourished group. In the malnourished group, maternal B12 levels were positively correlated with birth weight (rho 0.363, p = 0.003) and length (rho 0.330, p =0.008), whereas cord B12 levels were positively correlated with birth weight in the normally nourished group. (rho 0.277 p= 0.028) Conclusion High rates of vitamin B12 deficiency were observed in malnourished mothers and neonates. There was a positive correlation between birth weight, length, and maternal vitamin B12 levels in malnourished mothers. These findings emphasize the need to address maternal malnutrition and vitamin B12 deficiency to improve neonatal health.

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Association of maternal and cord vitamin B12 levels with anthropometry in term neonates born to malnourished mothers in coastal South India

GR,

Holla,

Manjrekar

et al. 2024

F1000Res

0

View full text Add to dashboard Cite

Background Malnourished pregnant women are at increased risk of micronutrient deficiency. We assessed the vitamin B12 status in both malnourished and normally nourished pregnant women and their neonates. Additionally, we studied the association between maternal B12 levels, cord B12 levels and neonatal anthropometry. Methods This cross-sectional study enrolled 63 malnourished and 63 normally nourished mothers and neonates. Maternal and cord blood samples were collected at the time of delivery for estimation of vitamin B12 levels. Maternal and cord vitamin B12 levels were compared using the Mann–Whitney U test. Neonatal anthropometry was correlated with maternal and cord B12 levels using Spearman’s correlation. Data were analyzed using SPSS version 25. Results Mean maternal age was 26.58 yrs. The median cord B12 levels were lower than the maternal B12 levels. Maternal B12 levels showed a strong positive correlation with cord B12 levels (rho = 0.879; p < 0.001). Maternal (p < 0.001) and cord (p < 0.001) vitamin B12 levels were significantly lower in the malnourished group than in the normally nourished group. In malnourished group, 66.8% mothers and 95.2% neonates were Vitamin B12 deficient, whereas 1.5% mothers and 4.7% neonates were vitamin B12 deficient in normally nourished group. In the malnourished group, maternal B12 levels were positively correlated with birth weight (rho 0.363, p = 0.003) and length (rho 0.330, p =0.008), whereas cord B12 levels were positively correlated with birth weight in the normally nourished group. (rho 0.277 p= 0.028) Conclusion High rates of vitamin B12 deficiency were observed in malnourished mothers and neonates. There was a positive correlation between birth weight, length, and maternal vitamin B12 levels in malnourished mothers. These findings emphasize the need to address maternal malnutrition and vitamin B12 deficiency to improve neonatal health.

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Vitamin B12 Supplementation During Pregnancy Influences Metabolic Factors in Male Sprague-Dawley Rat Offspring

Dimeji,

Adeoye,

Gujja

2024

Trends Med. Res

0

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Background and Objective: Maternal B 12 supplementation during pregnancy may have a significant impact on the health of the offspring, especially with regard to metabolic factors in male Sprague-Dawley rat offspring. This is because rats are a useful model for examining the effects of maternal nutrition, providing information on long-term health outcomes. This research explored the effects of perinatal vitamin B 12 supplementation on glucose metabolism and adiponectin release in male Sprague-Dawley rat offspring. Materials and Methods: Pregnant rats were divided into 4 groups: Normal or vitamin B 12 -enriched diets during pregnancy (PG), lactation (PGL), or both (PGL+), compared to control groups. Glucose tolerance, insulin resistance, fasting plasma glucose (FPG), fasting serum insulin concentration (FSI), lipids, body weight and food consumption were evaluated in male offspring at postnatal week 10. Also, lipid profile indices such as total cholesterol (T-CHOL), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were assayed. Results: Perinatal vitamin B 12 supplementation didn't affect maternal weight or food intake. However, PGL+offspring had higher birth weights and both PGL and PGL+groups showed a significant increase (p<0.05) in weight at week 10. Notably, supplemented groups had significantly (p<0.05) lower FPG, FSI, T-CHOL, TG, HDL-C and LDL-C levels and significantly (p<0.05) higher adiponectin levels. Conclusion: Early-life vitamin B 12 supplementation positively impacted metabolic parameters and adiponectin release in male Sprague-Dawley rat offspring, emphasizing early interventions for metabolic diseases.

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Vitamin B12 supplementation during pregnancy for maternal and child health outcomes

Cited by 3 publications

References 71 publications

Association of maternal and cord vitamin B12 levels with anthropometry in term neonates born to malnourished mothers in coastal South India

Association of maternal and cord vitamin B12 levels with anthropometry in term neonates born to malnourished mothers in coastal South India

Association of maternal and cord vitamin B12 levels with anthropometry in term neonates born to malnourished mothers in coastal South India

Vitamin B12 Supplementation During Pregnancy Influences Metabolic Factors in Male Sprague-Dawley Rat Offspring

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